Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$125K - $150K *

Join us to lead national process improvement initiatives, fostering operational excellence across diverse teams. Drive efficiencies, document workflows, and empower stakeholders, ensuring alignment wi...

Reposted 6 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$109K - $128K *

Empower industries by bridging cutting-edge IoT technology with operational excellence. Collaborate across teams to drive customer success while enhancing logistics, safety, and sustainability through...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$102K - $164K *

Develop and lead the strategy for Sales Incentive Plans, enhancing financial performance and team collaboration. Drive technology adoption and ensure accurate incentive calculations while fostering a...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$132K - $271K *

Drive software sales success by originating and qualifying opportunities, managing pipelines, and collaborating with clients and partners to deliver tailored solutions that meet business needs and exc...

6 days ago

  •   8 - 10 years exp.  •   Business Services

$154K - $278K *

Lead transformative energy projects by evaluating technologies, managing risks, and collaborating with diverse stakeholders. Help clients navigate the complexities of financial transactions and achiev...

United StatesRemote

Reposted 6 days ago

  •   11 - 15 years exp.  •   Technical Services

$132K - $271K *

Transform complex software sales cycles by delivering impactful demos, responding to client needs, and developing reusable pre-sales assets. Collaborate with stakeholders to enhance pipeline conversio...

6 days ago

  •   8 - 10 years exp.  •   Business Services

$108K - $177K *

Drive community health by delivering expert clinical pharmacy services, ensuring efficient medication management, patient counseling, and collaboration with healthcare teams to enhance patient outcome...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$152K - $190K *

Shape the future of IoT by driving complex sales to mid-sized customers, forging impactful relationships, and leading the charge in the digital transformation of essential industries. Enjoy a fully re...

RemoteRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$106K - $151K *

Reimagine customer engagement in the IoT space, driving innovative solutions for small to medium businesses. Leverage your sales expertise to navigate complex negotiations and build lasting relations...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$109K - $128K *

Empower your career as you collaborate with a dynamic team to drive the adoption of cutting-edge IoT solutions. You'll shape the future of essential industries by enhancing supply chains and ensuring...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Lead and grow a high-performing Guidewire practice, driving strategy and delivery excellence in digital transformations for insurance clients, while fostering client relationships and mentoring teams...

United StatesRemote

Reposted 6 days ago

  •   11 - 15 years exp.  •   Information Technology

$64K - $128K *

Optimize guest experiences by leading a dynamic sales team, driving sales growth, and managing multiple specialty departments. Foster a culture of accountability and excellence while ensuring product...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$85K - $100K *

Join a team that’s dedicated to ensuring accurate outpatient payment validation by applying your coding expertise and analytical skills to review and support compliance in billing and reimbursement pr...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Information Technology

$240K - $300K *

Join a dynamic team to enhance pain management services, providing compassionate care and collaborating across specialties to improve patient quality of life in a supportive, high-volume environment...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$107K - $162K *

Drive maintenance excellence by leading a team to enhance performance, ensure safety, and implement continuous improvement initiatives in a dynamic manufacturing environment...

6 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$133K - $156K *

Drive the development and modernization of core banking applications, leading a team of engineers to ensure system stability, operational efficiency, and alignment with business objectives while foste...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Transform field operations into effective learning solutions by bridging instructional design and hands-on training. Collaborate with stakeholders to identify performance gaps and develop competency-b...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$75K - $100K *

Champion the creative process by managing digital ad production, enhancing workflows, and collaborating with cross-functional teams to deliver high-quality marketing assets on time. Drive innovation a...

RemoteRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$350K - $400K *

Discover a fulfilling OB/GYN role focused on patient relationships and coordinated care. Join a collaborative team with advanced technology and strong clinical support, enhancing women's health across...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$69K - $95K *

Join a team that's dedicated to leveraging data analytics to drive sales success. As a key partner, you'll provide insights and innovative solutions that enhance decision-making and support strategic...

Reposted 6 days ago

  •   Less than 5 years exp.  •   Food & Beverages

$63K - $104K *

Lead the coordination of point-of-care testing compliance and training, ensuring adherence to regulatory standards while enhancing patient care quality through effective quality assurance and operatio...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$94K - $316K *

Elevate enterprise capabilities by designing and deploying agentic AI systems. Collaborate with clients to innovate workflows, integrate platforms, and ensure scalability across complex environments w...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Business Services

$152K - $190K *

Reimagine how mid-sized organizations leverage IoT data to drive efficiency and safety. As an integral sales force, you will engage with key decision-makers to build relationships, manage projects, an...

RemoteRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Collaborate to drive large-scale business initiatives, enhancing processes and stakeholder engagement. Analyze data and workflows to implement effective strategies, ensuring compliance and operational...

Missouri, USRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$250K - $300K *

Transform healthcare delivery by leading clinical strategy, quality improvement, and physician engagement. Drive operational excellence and foster a culture of innovation and collaboration to ensure e...

Reposted 6 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.