Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Manager - Business Development (IP & IP Litigation)
$100K - $130K *
Champion strategic growth by collaborating with practice groups to enhance business development initiatives, drive revenue, and support client engagement. Play a key role in shaping marketing strategi...
Reposted 5 days ago
$150K - $180K *
Lead the growth of strategic partner relationships, driving revenue through effective collaboration and pipeline management. Own a portfolio of partners, ensuring alignment and execution of joint busi...
5 days ago
Global Validation Scientist, Genetic Identity
$80K - $95K *
Empower forensic laboratories globally by validating cutting-edge DNA technologies. Collaborate with teams to ensure seamless integration of new systems, providing expert training and support to enhan...
5 days ago
Senior Structural Engineer | St. Louis, MO
$95K - $115K *
Elevate your career by leading complex structural engineering projects. Collaborate with teams to deliver innovative solutions, manage client relationships, and mentor junior staff while contributing...
5 days ago
Senior Structural Engineer | St. Louis, MO
$95K - $115K *
Shape the future of structural engineering by leading complex projects, mentoring teams, and delivering innovative solutions that meet client needs while promoting sustainable design practices...
5 days ago
Sr. Associate People Experience, Risk Management
$82K - $137K *
Oversee the implementation of risk management programs, ensuring compliance with EHS regulations and enhancing operational readiness. Collaborate with site leadership and stakeholders to promote safet...
5 days ago
$150K - $180K *
Lead the charge in driving growth through strategic partnerships, M&A, and de novo developments. Manage the full business development lifecycle while cultivating relationships with key stakeholders to...
5 days ago
Program Manager, Health Plan Payment Integrity (Claims & Recovery) Remote
$90K - $110K *
Reimagine health plan payment integrity by leading operational projects, analyzing claims data, and collaborating across teams to enhance compliance and financial outcomes. Drive strategic initiatives...
5 days ago
$150K - $180K *
Grow your career with a pivotal role bridging client challenges and omnichannel solutions. Lead strategic discovery, design tailored solutions, and drive impactful pilots to showcase value, ensuring a...
Reposted 5 days ago
$80K - $100K *
Drive new client acquisition and expansion by building strong relationships, identifying opportunities, and leveraging consultative sales techniques to increase revenue through corporate gifting solut...
Reposted 5 days ago
$138K - $165K *
Lead the charge in driving complex integration programs that connect products and platforms at scale. Collaborate across teams to ensure seamless interoperability and operational excellence, shaping t...
5 days ago
Specialty Sales Representative - IVIG
$125K - $200K *
Advance IVIG therapy sales by cultivating relationships, identifying opportunities, and collaborating with healthcare providers to enhance patient care and drive revenue growth in the specialty infusi...
Reposted 5 days ago
AI Conversation Design Senior Consultant
$130K - $200K *
Lead the charge in designing innovative AI conversational experiences, architecting multi-turn systems, and collaborating with clients to transform digital interactions across various platforms and ch...
5 days ago
AI Conversation Design Senior Consultant
$130K - $200K *
Lead the charge in designing innovative AI-driven conversational experiences, architecting multi-agent systems, and collaborating with clients to transform digital interactions across various platform...
5 days ago
$80K - $165K *
Analyze complex data from multiple sources to derive actionable insights that drive client success. Collaborate closely with cross-functional teams to create reports and recommendations tailored to cl...
Reposted 5 days ago
MCI ATC Training Instructional Supervisor
$80K - $95K *
Deliver exceptional training as an ATC Training Instructional Supervisor, overseeing instructional staff and ensuring high-quality training for air traffic controllers. Collaborate with FAA personnel...
5 days ago
$95K - $115K *
Join a team that's dedicated to optimizing plant performance while ensuring safety, quality, and compliance. Lead and mentor department heads, analyze data, and collaborate with R&D to drive innovatio...
Reposted 5 days ago
Senior Commissioning Engineer (Remote)
$142K - $178K *
Empower the future of energy by leading commissioning activities for HV substations, BESS, and PV projects. Oversee complex engineering tasks, mentor engineers, and ensure safe energization through in...
Reposted 5 days ago
ITS Epic Willow Inpatient Pharmacist Analyst II - Remote
$104K - $190K *
Shape the future of pharmacy IT by mentoring staff and enhancing application functionality. Collaborate on planning, development, and support while ensuring quality through effective testing and evalu...
5 days ago
Associate Vice President, Head of Commerce Practice
$180K - $250K *
Champion the future of commerce by leading our dynamic practice, driving growth, and optimizing client sales strategies across B2B and B2C channels. Shape innovative solutions and build lasting partne...
Reposted 5 days ago
Senior Cloud Security Engineer
$160K - $165K *
Join a team that's dedicated to enhancing cloud security for critical operations. Leverage your expertise to identify vulnerabilities, respond to incidents, and implement robust security measures in c...
Reposted 5 days ago
Project Manager (Traveling) Multiple Openings
$132K - $159K *
Lead project management efforts by overseeing the entire project life cycle, ensuring budget adherence, risk management, and exceptional stakeholder communication while fostering team collaboration an...
5 days ago
Senior Analyst, Professional Medicaid Reimbursement - SQL/QNXT/NetworX - Remote
$80K - $95K *
Unlock potential by providing senior-level analyst support for complex provider reimbursement activities. Collaborate with stakeholders to implement and maintain reimbursement methodologies across var...
Reposted 5 days ago
Configuration Analyst - Drug File/VA Oracle Health (Hybrid Kansas City MO Office)
$53K - $132K *
Optimize the configuration and implementation of Oracle Health Drug File systems for client projects. Collaborate with cross-functional teams to ensure successful execution and provide technical exper...
Reposted 5 days ago
$80K - $96K *
Drive your sales career forward by leading a dynamic team, building client relationships, and implementing proven strategies. Enjoy flexibility while mentoring others and providing tailored insurance...
Reposted 5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.