Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$87K - $157K *

Lead the charge in transforming healthcare data solutions by leveraging advanced SQL, Snowflake, and SAS expertise. Collaborate with cross-functional teams to enhance business processes and ensure com...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $120K *

Transform your career by joining a dynamic veterinary team dedicated to excellence and compassion. Collaborate with experienced professionals as you engage in diverse cases, nurturing both patients an...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$132K - $165K *

Transform user experiences by crafting streamlined flows, building robust APIs, and integrating third-party software. Collaborate with a dynamic team to deliver elegant solutions while advocating for...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$204K - $290K *

Lead the charge in creating seamless cardholder experiences by driving technical strategy, collaborating across teams, and fostering a culture of quality and ownership in a dynamic, AI-driven environm...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$135K - $149K *

Analyze and enhance IT infrastructure through secure cloud solutions, ensuring 24x7 availability. Collaborate with teams to streamline workflows, improve system reliability, and tackle complex challen...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Elevate sales performance by developing new business opportunities in North America. Drive customer acquisition through tailored MES & ERP solutions while managing the full sales cycle and collaborati...

5 days ago

  •   Less than 5 years exp.  •   Food & Beverages

$80K - $95K *

Optimize supply chain processes by managing inventory, forecasting demand, and ensuring seamless material flow from order to delivery. Collaborate with cross-functional teams to enhance service levels...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$185K - $225K *

Champion exceptional member experiences by leading operations, developing talent, and ensuring financial success in a dynamic private club environment. Drive collaboration and accountability while enh...

5 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$95K - $115K *

Deliver impactful project management by co-managing resources, schedules, and risks. Ensure compliance and alignment with strategic goals while utilizing reporting tools to track performance and drive...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Join us to lead talent acquisition and development initiatives, fostering a culture of growth and training. Collaborate with leaders to enhance staffing strategies and build programs that empower empl...

5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$101K - $169K *

Optimize North American sales processes and systems to enhance efficiency, drive adoption, and improve outcomes. Collaborate with teams to identify issues, implement solutions, and ensure consistent u...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Transportation

$90K - $110K *

Drive operational excellence by coordinating care, managing processes, and fostering innovation. Lead teams to enhance patient safety and quality while addressing system issues and promoting self-deve...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $220K *

Pioneer innovative sales strategies as you engage with clients, guiding them through the QuotaPath platform. Leverage AI tools to enhance efficiency and influence product development while driving new...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $195K *

Contribute to the success of IVD and CDx programs by leading cross-functional teams through development, validation, and submission processes. Drive strategic execution and ensure alignment with regul...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$184K - $356K *

Join a team that's pushing the boundaries of AI technology. As a Deep Learning Engineer, you'll integrate advanced CUDA features and optimize frameworks for high-performance AI applications, tackling...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$86K - $173K *

Unlock potential by driving growth in a dynamic sales environment, engaging with diverse stakeholders to close new business and expand existing accounts in the healthcare sector. Embrace a remote role...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Drive logistics optimization and cost reduction initiatives across global service operations, enhancing efficiency and performance in transportation and network design while collaborating with cross-f...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$188K - $245K *

Drive the vision for a unified longitudinal patient record, ensuring data accuracy and completeness across multiple sources. Collaborate with cross-functional teams to enhance clinical data utility an...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $160K *

Transform the future of AI by designing cutting-edge datasets and benchmarks. Collaborate with partners and cross-functional teams to drive impactful research and commercial strategies, enhancing mode...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$155K - $410K *

Innovate the future of finance technology as you lead Oracle Cloud implementations. Drive strategic direction and enhance operational effectiveness while mentoring teams and fostering impactful client...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$128K - $160K *

Elevate your coaching career by guiding IT managed service leaders to transform ambition into actionable results. Leverage your experience to foster accountability and drive meaningful progress in a d...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$103K - $127K *

Help us develop profitable business relationships while increasing account revenue. Leverage market insights and strategic sales techniques to identify opportunities and drive growth through consultat...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Join a dynamic team as a System Engineer, specializing in Linux systems and automation. You'll lead the design and maintenance of provisioning workflows, configuration management, and Linux networking...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $135K *

Analyze supplier capabilities and integrate quality into engineering processes. Contribute to continuous improvement initiatives, ensuring compliance with specifications and regulations while fosterin...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$240K - $270K *

Champion advanced analytics to drive strategic insights and business growth. Lead a hands-on team, collaborating with cross-functional partners to enhance product performance, retention, and decision...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Food & Beverages

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.