Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$70K - $117K *

Lead innovative structural engineering solutions for marine vessels, ensuring integrity and compliance with maritime standards. Collaborate with teams to enhance operational safety and performance in...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$104K - $130K *

Join a team that's shaping the future of power systems for mission-critical facilities. Collaborate on complex projects, conduct in-depth studies, and enhance your expertise in a dynamic remote enviro...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Technical Services

$135K - $160K *

Shape the future of digital experiences for financial advisors, leading a team to enhance practice growth through AI-driven insights and strategic initiatives. Drive cross-functional collaboration and...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$193K - $230K *

Contribute to the growth of Air Traffic Control solutions by developing strategic customer relationships, identifying new business opportunities, and managing the sales cycle to enhance market presenc...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$120K - $180K *

Lead integrated campaign strategies that drive measurable pipeline growth across diverse business offerings. Collaborate with marketing teams to translate complex value propositions into clear messagi...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$115K - $125K *

Champion the configuration of our Ascend 2.0 platform by leading spec negotiations and ensuring data quality for client onboarding. Collaborate cross-functionally, manage multiple implementations, and...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $200K *

Join a collaborative team to deliver exceptional orthodontic care in a modern practice. Enjoy clinical autonomy, mentorship, and a supportive environment while maximizing your earnings and achieving w...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Join a team that's shaping the future of DevSecOps by guiding customers in building robust processes. Collaborate across departments to deliver tailored solutions and showcase the value of innovative...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$163K - $204K *

Partner with us to architect and enhance our next-gen web console, driving frontend infrastructure and user experience across multiple products while ensuring robust security and seamless integration...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$87K - $157K *

Champion enterprise employee recognition programs to enhance engagement, oversee design and implementation, manage multiple initiatives, and ensure alignment with organizational goals while fostering...

Missouri, USRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$192K - $338K *

Lead transformative AI and data strategies for enterprise accounts, driving value through hands-on engagement and technical leadership. Collaborate with executives to deliver tailored solutions that e...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Information Technology

$183K - $270K *

Champion IAM initiatives by leading technical implementations and team growth, ensuring seamless access and compliance across global operations while driving automation and user-centric solutions...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$100K - $125K *

Optimize game development by enhancing build systems and automating infrastructure. Collaborate with teams to ensure reliable deployments across multiple platforms, driving efficiency and innovation i...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$118K - $147K *

Unlock potential by leading cross-functional teams in mission-critical projects. Oversee deliverables, manage client relationships, and drive strategic business development while ensuring project obje...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$139K - $174K *

Join a team that's shaping the future of mission-critical projects. Lead cross-functional teams, oversee deliverables, and enhance client relationships while managing complex, large-scale projects in...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Optimize your skills as a .NET Developer, focusing on software development, testing, and maintenance. Collaborate with a team to deliver high-quality applications while keeping up with industry standa...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Drive partner success by managing a portfolio of consulting and technology partners, building joint pipelines, and enabling co-selling strategies to achieve revenue goals in a dynamic B2B SaaS environ...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Lead the development of innovative software solutions by mastering .NET technologies, collaborating with cross-functional teams, and delivering high-quality applications that transform client needs in...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$170K - $200K *

Shape the future of anesthesia care in a collaborative environment, focusing on diverse cases with a supportive team. Enjoy a balanced call rotation and the freedom to lead innovative programs while p...

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$98K - $112K *

Analyze financial crime risks by leading a team of investigators and analysts. Oversee complex investigations, enhance monitoring systems, and develop intelligence to mitigate risks while ensuring com...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$104K - $126K *

Lead the charge in managing a dynamic Financial Crimes Intelligence team, overseeing investigations, enhancing monitoring systems, and developing strategies to mitigate financial crime risks while ens...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$122K - $155K *

Advance executive visibility and engagement by coordinating high-impact events and communications. Collaborate with senior leadership to enhance corporate reputation and strengthen stakeholder relatio...

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Elevate your career by developing innovative Salesforce solutions that enhance customer support and experience. Collaborate with cross-functional teams to design, implement, and optimize integrations...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$107K - $147K *

Unlock potential by joining a dynamic team to build scalable applications, tackle distributed systems challenges, and leverage AI for smarter development. Collaborate closely with product management a...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$114K - $167K *

Lead the charge in optimizing ERP systems through advanced customizations, integration solutions, and data migration strategies. Collaborate with teams to enhance performance, ensure compliance, and d...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.