Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $95K *

Champion complex LTC Professional Liability claims, managing them from inception to resolution. Collaborate with experts and leadership to shape strategies, ensuring effective outcomes in a high-stake...

United StatesRemote

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  •   5 - 7 years exp.  •   Finance & Insurance

$104K - $156K *

Lead the design, development, and integration of AI applications that enhance business operations. Collaborate with cross-functional teams to deliver technical solutions while maintaining security, re...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$89K - $109K *

Drive project accounting excellence by leading a team, ensuring accurate billing, and collaborating with project managers. Oversee financial reporting and client relations while mentoring junior staff...

United StatesRemote

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  •   5 - 7 years exp.  •   Healthcare

$60K - $115K *

Transform your career by managing financial processes and compliance, analyzing project health, and training teams. Collaborate with stakeholders to ensure effective financial deliverables and reporti...

United StatesRemote

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  •   Less than 5 years exp.  •   Real Estate & Construction

$130K - $185K *

Unlock insights at scale by transforming complex healthcare data into actionable analytics solutions. Collaborate with cross-functional teams to design and optimize data models, ensuring high-quality...

United StatesRemote

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  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$165K - $185K *

Lead the charge in healthcare data integration by analyzing source systems, designing database objects, and ensuring compliance with governance policies to support the Corporate Data Warehouse...

United StatesRemote

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  •   8 - 10 years exp.  •   Information Technology

$94K - $120K *

Lead the charge in delivering impactful IT projects by managing all phases from initiation to closeout. Collaborate with diverse teams to ensure timely and successful project execution while aligning...

United StatesRemote

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  •   5 - 7 years exp.  •   Information Technology

$385K - $416K *

Champion clinical expertise in birth defects research, overseeing case classification and quality control. Collaborate with multidisciplinary teams to ensure accurate data management and support publi...

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  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$116K - $155K *

Transform enterprise applications through strategic architecture, integration, and governance. Collaborate with stakeholders to enhance business processes and ensure reliable operation of platforms wh...

United StatesRemote

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  •   5 - 7 years exp.  •   Energy & Utilities

$120K - $130K *

Elevate adolescent mental health care by providing trauma-informed psychiatric evaluations, medication management, and collaborative treatment plans in a supportive environment dedicated to emotional...

Today

  •   Less than 5 years exp.  •   Healthcare

$190K - $215K *

Engage in the design and development of robust full-stack solutions, guiding teams in secure engineering practices while integrating innovative technologies in a federal environment. Drive impactful c...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Manage complex digital investigations and data preservation efforts, leading a team in the collection and analysis of electronically stored information (ESI) while ensuring compliance with legal proto...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$74K - $91K *

Join our team to investigate healthcare fraud, waste, and abuse through data analysis. Utilize your expertise in Excel and communication skills to analyze cases, conduct interviews, and support legal...

United StatesRemote

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  •   5 - 7 years exp.  •   Healthcare

$96K - $99K *

Elevate care standards by managing a dedicated team, coordinating admissions, and ensuring residents receive exceptional support and safety in a nurturing environment...

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$72K - $110K *

Grow your career with a dynamic sales team focused on driving market share and customer satisfaction across the Caribbean. Leverage your relationship-building skills to foster partnerships and deliver...

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  •   Less than 5 years exp.  •   Food & Beverages

$72K - $110K *

Unlock potential by driving sales growth and building strong relationships in your territory. Collaborate with a dynamic team to deliver exceptional customer service and innovative solutions, while en...

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  •   Less than 5 years exp.  •   Food & Beverages

$72K - $110K *

Lead the charge in driving sustainable sales growth and market share in your territory. Collaborate with retailers to implement product strategies and enhance customer satisfaction while building stro...

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  •   Less than 5 years exp.  •   Food & Beverages

$155K - $175K *

Champion employee relations by leading a multi-site team, driving strategic oversight, and ensuring effective resolution of workplace issues while partnering with legal and HR functions to maintain co...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Transportation

$180K - $210K *

Drive strategic growth and operational excellence in IT program management, overseeing federal contracts and leading Agile teams to enhance supply chain solutions for the Department of Veterans Affair...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Information Technology

$80K - $120K *

Transform claims management by leveraging expertise in commercial casualty claims, focusing on product and premises liability. Collaborate with a dedicated team to deliver exceptional outcomes while m...

United StatesRemote

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  •   8 - 10 years exp.  •   Finance & Insurance

$180K - $220K *

Elevate your career by leading global marketing strategies that drive demand generation, enhance brand positioning, and support revenue growth in the healthcare technology sector. Collaborate with cro...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Healthcare

$75K - $123K *

Lead the execution of Clinical Validation Audit quality programs, managing a team to ensure compliance with standards and client expectations while driving continuous improvement and operational effic...

United StatesRemote

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  •   5 - 7 years exp.  •   Business Services

$200K - $260K *

Unlock potential by driving new business sales in the Fintech sector, leveraging industry expertise to cultivate strategic relationships and deliver tailored solutions that meet client needs across No...

United StatesRemote

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  •   8 - 10 years exp.  •   Business Services

$75K - $107K *

Unlock potential by delivering impactful training experiences that enhance audit quality and accuracy. Collaborate with clinical experts to translate complex guidelines into engaging learning material...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$93K - $154K *

Transform claims analysis by leveraging deep operational insights to identify patterns and anomalies. Collaborate with cross-functional teams to develop advanced data mining capabilities that enhance...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.