Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $105K *

Advance aftermarket sales by managing accounts, ensuring customer satisfaction, and driving growth through strategic engagement and support. Collaborate with teams to close sales and identify opportun...

5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$120K - $145K *

Shape the future of secure software delivery by embedding security throughout development and operations, enhancing collaboration, and optimizing CI/CD processes while ensuring automated maintenance a...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$85K - $141K *

Elevate compliance standards by conducting thorough due diligence assessments for strategic account pharmacies, analyzing data, and collaborating with cross-functional teams to ensure adherence to reg...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$72K - $99K *

Engage in life-saving patient care as a Registered Nurse in outpatient dialysis. Collaborate with a dedicated team, monitor treatment plans, and educate patients on kidney health. Flexible shifts and...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Join a team that's dedicated to enhancing patient care by overseeing pharmacy operations, mentoring staff, and ensuring high-quality pharmaceutical services. Your leadership will drive clinical excell...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$206K - $309K *

Lead a global team of engineers to enhance our Agent Platform, ensuring operational health and reliability while driving innovative re-architecture. Collaborate with cross-functional teams to deliver...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$147K - $195K *

Analyze financial data and lead budgeting processes to drive strategic decision-making. Collaborate with senior leadership to enhance operational efficiency and deliver actionable insights in a dynami...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$201K - $251K *

Champion the US medical strategy for Non-Small Cell Lung Cancer, leading execution across the portfolio. Collaborate with cross-functional teams to translate clinical evidence into actionable plans, e...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$105K - $131K *

Lead the charge in expanding our civil government business in Texas. Develop strategies, build relationships, and drive growth by navigating government agencies and closing large-scale contracts. Make...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$100K - $120K *

Accelerate the growth of a high-performing team by leading training, onboarding, and strategic initiatives to enhance dealer relationships and drive customer success in a dynamic SaaS environment...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $210K *

Lead the charge in advancing renewable energy projects by developing dynamic models, conducting studies, and preparing technical reports. Collaborate with clients and vendors to ensure successful proj...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$143K - $220K *

Unlock the potential of credit analytics by developing predictive models and optimizing strategies. Collaborate across teams to drive data-informed decisions that enhance lending growth and improve ri...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Elevate your career by leading SCADA design and engineering for high-voltage electrical power systems. Collaborate with a multi-disciplinary team to optimize substation projects, ensuring efficient ex...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$56K - $125K *

Drive store operations and enhance customer experiences by managing team performance, optimizing inventory, and implementing effective merchandising strategies to boost sales and profitability...

5 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$120K - $140K *

Empower your career by driving product marketing success through strategic commercialization, effective messaging, and cross-functional collaboration. Lead initiatives that translate complex data solu...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $250K *

Champion the evolution of HR Business Partnering globally, driving strategic workforce initiatives and organizational effectiveness while partnering with senior leaders to enhance talent and leadershi...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Join us to lead the development of cutting-edge Operational AI solutions, collaborating with Global 2000 engineering teams. Drive technical integrity from architecture to production, ensuring impactfu...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Accelerate progress at a leading tech firm by driving go-to-market planning and operational execution. Lead strategic initiatives, manage forecasting, and enhance cross-functional alignment to support...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$106K - $284K *

Join a dynamic team to design and deliver innovative iOS solutions that enhance customer health experiences. Collaborate across functions, lead technical initiatives, and drive the development of secu...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$185K - $260K *

Drive innovation by leading the orchestration of AI agents, enhancing customer interactions through seamless multi-agent collaboration and robust evaluation frameworks. Collaborate with cross-function...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$180K - $200K *

Unlock growth by leading strategic customer relationships, driving innovative solutions, and enhancing partnerships. Collaborate across teams to deliver exceptional experiences and maximize revenue in...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$100K - $250K *

Drive growth and revenue in the public safety sector by managing sales opportunities, building relationships, and executing territory plans. Collaborate with teams to deliver solutions that meet evolv...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$96K - $181K *

Help us redefine commercial lending by leading product strategy and execution. Drive innovation in loan origination and underwriting, enhancing client experiences and operational efficiency through cr...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$62K - $103K *

Join a dynamic team to conduct open-source research and analysis, supporting senior officials with timely insights on national security topics. This remote role requires effective communication and a...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Lead the proposal lifecycle by collaborating with cross-functional teams to create compelling, compliant proposals that drive growth in government contracting. Utilize your expertise to enhance proces...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.