Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$200K - $450K *

Inspire innovation in global therapeutic strategies, leading scientific expertise and operational execution across a diverse therapeutic landscape, while ensuring high-quality delivery and compliance...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$138K - $184K *

Lead the charge in designing resilient electrical systems for mission-critical facilities. Collaborate with teams to oversee full-cycle electrical design, ensuring high availability and operational ex...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Technical Services

$83K - $104K *

Empower your career by collaborating on innovative electrical designs for mission-critical facilities. Engage with senior engineers, enhance your skills, and contribute to impactful projects while wor...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Technical Services

$104K - $157K *

Unlock potential by bridging innovative R&D designs with high-speed production, ensuring precision and quality in ammunition manufacturing for national defense. Collaborate with experts to transform c...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$170K - $200K *

Unlock potential by leading advisor segmentation strategies that enhance advisor outcomes and align enterprise resources. Drive measurable execution while fostering collaboration across teams to deliv...

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$178K - $338K *

Redefine financial planning with leadership in Workday Adaptive Planning implementations. Collaborate across teams to enhance reporting, optimize processes, and drive enterprise performance management...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$99K - $132K *

Empower your career by leveraging technology to drive innovative solutions. Collaborate with sales teams to analyze customer needs, architect tailored solutions, and present compelling proposals that...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$89K - $107K *

Drive innovation in application integration by designing and supporting secure data flows across enterprise systems. Collaborate with teams to enhance performance and ensure data integrity while lever...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Lead the design and governance of enterprise security programs, enhancing vulnerability management and attack surface security. Drive risk reduction initiatives across complex environments while commu...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Transform healthcare technology by owning product vision, strategy, and delivery. Collaborate with cross-functional teams to enhance user workflows and implement AI solutions, driving efficiency and m...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Shape the future of client relationships in the metals industry by driving sales, managing key accounts, and ensuring customer satisfaction. Leverage market expertise to identify opportunities and fos...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$135K - $150K *

Join a dynamic team managing large-scale construction projects, focusing on automated systems. Lead site operations, oversee contract management, and ensure quality execution while maintaining budget...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$170K - $210K *

Lead the design management of owner-furnished electrical equipment for a hyperscale data center, ensuring integration, compliance, and quality standards while guiding teams and managing client communi...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$175K - $210K *

Architect transformative R&D initiatives that leverage AI and ML, ensuring platform stability and excellence. Join dynamic teams to drive innovation and quality in clinical technology solutions at a g...

RemoteRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join a dynamic team to manage complex projects, ensuring timely delivery and quality. Utilize your analytical skills to develop reports and cost estimates while coordinating with government representa...

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$225K - $275K *

Lead the charge in transforming FP&A through automation and AI, enhancing financial insights and strategic partnerships across the organization. Drive efficient planning, forecasting, and reporting to...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$72K - $90K *

Unlock operational excellence by providing high-level administrative support to four VPs in a dynamic R&D Oncology environment. Enhance productivity, manage complex schedules, and coordinate key initi...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $115K *

Accelerate progress at the intersection of technology and client success. Own client relationships, drive program launches, and collaborate with cross-functional teams to ensure client goals are met w...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$108K - $162K *

Lead the charge in driving corporate sales of high purity water treatment solutions across industrial accounts. Develop strategic initiatives to grow business in the power generation and petrochemical...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$125K - $156K *

Transform your career by leading CPQ initiatives that enhance sales efficiency and streamline order processes. Collaborate across teams to drive impactful solutions and ensure a seamless user experien...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$76K - $142K *

Manage construction projects across varying locations, ensuring adherence to deadlines, budgets, and technical requirements. Collaborate with multidisciplinary teams to achieve project goals while nav...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$106K - $161K *

Join a team that's shaping product strategy and leading a talented group of Product Managers. Drive innovation, balance customer needs with technical feasibility, and enhance AI integration across a c...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$97K - $134K *

Help us shape the future of audio technology by developing innovative DSP algorithms that enhance sound experiences across diverse platforms and products, collaborating with engineers to deliver clear...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$80K - $105K *

Join a team that's dedicated to managing and expanding aftermarket sales accounts, ensuring customer satisfaction and retention while driving growth through effective communication and strategic sales...

5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$80K - $105K *

Serve as a key point of contact for aftermarket sales, managing accounts and driving growth through customer engagement, sales strategy execution, and relationship building, while ensuring satisfactio...

5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.