Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Vice President, Global Therapeutic Area Leader, Oncology
$200K - $450K *
Inspire innovation in global therapeutic strategies, leading scientific expertise and operational execution across a diverse therapeutic landscape, while ensuring high-quality delivery and compliance...
Reposted 5 days ago
Lead Electrical Engineer, Datacenter
$138K - $184K *
Lead the charge in designing resilient electrical systems for mission-critical facilities. Collaborate with teams to oversee full-cycle electrical design, ensuring high availability and operational ex...
5 days ago
$83K - $104K *
Empower your career by collaborating on innovative electrical designs for mission-critical facilities. Engage with senior engineers, enhance your skills, and contribute to impactful projects while wor...
5 days ago
$104K - $157K *
Unlock potential by bridging innovative R&D designs with high-speed production, ensuring precision and quality in ammunition manufacturing for national defense. Collaborate with experts to transform c...
Reposted 5 days ago
Senior Director, Advisor Segmentation
$170K - $200K *
Unlock potential by leading advisor segmentation strategies that enhance advisor outcomes and align enterprise resources. Drive measurable execution while fostering collaboration across teams to deliv...
5 days ago
Workday Adaptive Planning Senior Manager
$178K - $338K *
Redefine financial planning with leadership in Workday Adaptive Planning implementations. Collaborate across teams to enhance reporting, optimize processes, and drive enterprise performance management...
Reposted 5 days ago
$99K - $132K *
Empower your career by leveraging technology to drive innovative solutions. Collaborate with sales teams to analyze customer needs, architect tailored solutions, and present compelling proposals that...
5 days ago
Application Integration Engineer 1
$89K - $107K *
Drive innovation in application integration by designing and supporting secure data flows across enterprise systems. Collaborate with teams to enhance performance and ensure data integrity while lever...
5 days ago
$110K - $130K *
Lead the design and governance of enterprise security programs, enhancing vulnerability management and attack surface security. Drive risk reduction initiatives across complex environments while commu...
5 days ago
$95K - $115K *
Transform healthcare technology by owning product vision, strategy, and delivery. Collaborate with cross-functional teams to enhance user workflows and implement AI solutions, driving efficiency and m...
5 days ago
$80K - $95K *
Shape the future of client relationships in the metals industry by driving sales, managing key accounts, and ensuring customer satisfaction. Leverage market expertise to identify opportunities and fos...
Reposted 5 days ago
$135K - $150K *
Join a dynamic team managing large-scale construction projects, focusing on automated systems. Lead site operations, oversee contract management, and ensure quality execution while maintaining budget...
Reposted 5 days ago
Electrical OFCI Design Manager - Data Center Construction
$170K - $210K *
Lead the design management of owner-furnished electrical equipment for a hyperscale data center, ensuring integration, compliance, and quality standards while guiding teams and managing client communi...
5 days ago
$175K - $210K *
Architect transformative R&D initiatives that leverage AI and ML, ensuring platform stability and excellence. Join dynamic teams to drive innovation and quality in clinical technology solutions at a g...
Reposted 5 days ago
$95K - $115K *
Join a dynamic team to manage complex projects, ensuring timely delivery and quality. Utilize your analytical skills to develop reports and cost estimates while coordinating with government representa...
5 days ago
$225K - $275K *
Lead the charge in transforming FP&A through automation and AI, enhancing financial insights and strategic partnerships across the organization. Drive efficient planning, forecasting, and reporting to...
5 days ago
$72K - $90K *
Unlock operational excellence by providing high-level administrative support to four VPs in a dynamic R&D Oncology environment. Enhance productivity, manage complex schedules, and coordinate key initi...
5 days ago
$85K - $115K *
Accelerate progress at the intersection of technology and client success. Own client relationships, drive program launches, and collaborate with cross-functional teams to ensure client goals are met w...
5 days ago
$108K - $162K *
Lead the charge in driving corporate sales of high purity water treatment solutions across industrial accounts. Develop strategic initiatives to grow business in the power generation and petrochemical...
Reposted 5 days ago
Configure Price Quote (CPQ) Manager
$125K - $156K *
Transform your career by leading CPQ initiatives that enhance sales efficiency and streamline order processes. Collaborate across teams to drive impactful solutions and ensure a seamless user experien...
5 days ago
Traveling Construction Project Engineer
$76K - $142K *
Manage construction projects across varying locations, ensuring adherence to deadlines, budgets, and technical requirements. Collaborate with multidisciplinary teams to achieve project goals while nav...
Reposted 5 days ago
$106K - $161K *
Join a team that's shaping product strategy and leading a talented group of Product Managers. Drive innovation, balance customer needs with technical feasibility, and enhance AI integration across a c...
5 days ago
$97K - $134K *
Help us shape the future of audio technology by developing innovative DSP algorithms that enhance sound experiences across diverse platforms and products, collaborating with engineers to deliver clear...
5 days ago
Aftermarket Sales Account Specialist
$80K - $105K *
Join a team that's dedicated to managing and expanding aftermarket sales accounts, ensuring customer satisfaction and retention while driving growth through effective communication and strategic sales...
5 days ago
Aftermarket Sales Account Specialist
$80K - $105K *
Serve as a key point of contact for aftermarket sales, managing accounts and driving growth through customer engagement, sales strategy execution, and relationship building, while ensuring satisfactio...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.