Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $95K *

Lead clinical operations and patient care in the Main Operating Room during weekends, ensuring high-quality outcomes and efficient workflows while mentoring staff and collaborating with surgical teams...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Join a team that's dedicated to sourcing top technical talent for innovative automation solutions. Leverage your recruiting expertise to engage candidates and support our mission of enhancing efficien...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Accelerate progress at enterprise-level accounts by driving new-logo acquisition and managing a strategic territory plan. Engage C-suite stakeholders and lead complex sales cycles to achieve significa...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$211K - $264K *

Transform learning experiences by leading the strategy and operations of our enterprise learning technology ecosystem, ensuring effective governance and seamless integration across platforms to enhanc...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$145K - $220K *

Drive the marketing strategy and pipeline generation for a high-growth B2B company. Lead a dynamic team to create demand, optimize engagement, and deliver measurable results while fostering a culture...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$179K - $293K *

Drive regulatory strategies for In Vitro Diagnostics and Digital Health, overseeing development, submissions, and commercialization. Collaborate with stakeholders and lead health authority meetings to...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$190K - $210K *

Drive success by leading a high-impact Cyber Security Sales team, achieving sales targets, and fostering strategic partnerships. Collaborate across functions to align technical and business strategies...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Transform the future of intelligent compiler technologies by designing and optimizing advanced systems that enhance developer productivity and system performance across software and hardware boundarie...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Lead the charge in R&D lifecycle management, overseeing complex formulation projects from concept to commercialization. Collaborate cross-functionally to enhance product development, streamline proces...

5 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$215K - $320K *

Champion strategic asset allocation and lead cross-functional initiatives to enhance investment processes, governance, and operational efficiency, ensuring alignment with enterprise priorities and reg...

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$140K - $167K *

Champion growth by driving Chainguard's SEO and developer marketing strategies. Collaborate cross-functionally to enhance visibility and user adoption, focusing on measurable outcomes and pipeline gro...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$108K - $251K *

Empower customer success by leading the design and implementation of AI and CCaaS solutions. Collaborate with cross-functional teams to create scalable architectures that enhance customer experience a...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Consumer Technology

$265K - $290K *

Unlock growth by shaping our partner go-to-market strategy in the Western region. Collaborate with cross-functional teams to drive revenue through strategic partnerships, enhancing our channel ecosyst...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$124K - $280K *

Unlock potential by leading SAP application development and integration projects. As a Senior Manager, you'll guide teams through complex challenges, shape solutions, and enhance operational efficienc...

5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$124K - $280K *

Lead transformative SAP projects, guiding teams through complex integrations and application development. Empower clients with innovative solutions that enhance operational efficiency and align with s...

5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$110K - $130K *

Champion a high-performing sales team by driving revenue growth, coaching talent, and executing strategic initiatives. Leverage data insights to enhance performance and foster a culture of accountabil...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$105K - $124K *

Join a team that's driving mainframe API modernization and reliability. Leverage your expertise in IBM z/OS Connect, REST APIs, and automation to enhance system performance and security in a dynamic I...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Unlock potential by leading Oracle Financials implementations, driving discovery, architecture, and hands-on configuration across multiple engagements. Collaborate with finance teams to deliver tailor...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$90K *

Lead the charge in delivering exceptional clinical support and training for patient monitoring systems. Collaborate with teams to ensure timely implementation and ongoing customer satisfaction across...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Unlock your potential as an Oracle Data Migration Architect, leading complex data conversions from legacy systems to Oracle Fusion Cloud. Collaborate with cross-functional teams to ensure seamless exe...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $190K *

Join a team that's transforming database reliability through innovative architecture and cloud technologies. Collaborate cross-functionally to enhance performance, tackle production issues, and ensure...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$91K - $137K *

Accelerate progress at the forefront of global site start-up activities, managing strategies and coordinating efforts to ensure timely activation. Collaborate with stakeholders and mentor teams to dri...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$143K - $194K *

Pioneer innovative strategies for a Virtual First work stream, enhancing employee effectiveness through technology and research. Lead cross-functional initiatives, manage complex programs, and drive m...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$200K - $225K *

Lead the charge in developing strategies for client retention and growth, optimizing team performance, and building robust client relationships to enhance customer experiences and achieve revenue targ...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$83K - $88K *

Optimize patient care by managing telephonic case management for Workers' Compensation claims. Leverage clinical expertise to ensure timely recovery and return-to-work outcomes while maintaining high...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.