Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
RN Supervisor - Weekend Option (Main Operating Room)
$80K - $95K *
Lead clinical operations and patient care in the Main Operating Room during weekends, ensuring high-quality outcomes and efficient workflows while mentoring staff and collaborating with surgical teams...
5 days ago
Technical Recruiter - Controls and Robotics Engineering
$80K - $95K *
Join a team that's dedicated to sourcing top technical talent for innovative automation solutions. Leverage your recruiting expertise to engage candidates and support our mission of enhancing efficien...
5 days ago
Account Executive, Enterprise (Acquisition) - Midwest
$125K - $150K *
Accelerate progress at enterprise-level accounts by driving new-logo acquisition and managing a strategic territory plan. Engage C-suite stakeholders and lead complex sales cycles to achieve significa...
5 days ago
Director, Global Corporate Learning Management Systems
$211K - $264K *
Transform learning experiences by leading the strategy and operations of our enterprise learning technology ecosystem, ensuring effective governance and seamless integration across platforms to enhanc...
5 days ago
Head of Marketing - Remote, USA
$145K - $220K *
Drive the marketing strategy and pipeline generation for a high-growth B2B company. Lead a dynamic team to create demand, optimize engagement, and deliver measurable results while fostering a culture...
5 days ago
Associate Director, Regulatory Affairs - In Vitro Diagnostics and Digital Health
$179K - $293K *
Drive regulatory strategies for In Vitro Diagnostics and Digital Health, overseeing development, submissions, and commercialization. Collaborate with stakeholders and lead health authority meetings to...
5 days ago
Cyber Security Sales Team Lead
$190K - $210K *
Drive success by leading a high-impact Cyber Security Sales team, achieving sales targets, and fostering strategic partnerships. Collaborate across functions to align technical and business strategies...
Reposted 5 days ago
Senior Compiler Engineer, Agentic Compiler Systems
$150K - $180K *
Transform the future of intelligent compiler technologies by designing and optimizing advanced systems that enhance developer productivity and system performance across software and hardware boundarie...
5 days ago
Sr. Scientist - R&D Life Cycle
$95K - $115K *
Lead the charge in R&D lifecycle management, overseeing complex formulation projects from concept to commercialization. Collaborate cross-functionally to enhance product development, streamline proces...
5 days ago
Managing Director, Strategic Asset Allocation
$215K - $320K *
Champion strategic asset allocation and lead cross-functional initiatives to enhance investment processes, governance, and operational efficiency, ensuring alignment with enterprise priorities and reg...
5 days ago
Sr. Growth Marketing Manager, AI Discovery
$140K - $167K *
Champion growth by driving Chainguard's SEO and developer marketing strategies. Collaborate cross-functionally to enhance visibility and user adoption, focusing on measurable outcomes and pipeline gro...
5 days ago
Senior Global Solutions Architect
$108K - $251K *
Empower customer success by leading the design and implementation of AI and CCaaS solutions. Collaborate with cross-functional teams to create scalable architectures that enhance customer experience a...
5 days ago
Strategic Channel Manager | Remote | West Coast US
$265K - $290K *
Unlock growth by shaping our partner go-to-market strategy in the Western region. Collaborate with cross-functional teams to drive revenue through strategic partnerships, enhancing our channel ecosyst...
5 days ago
SAP Tech Lead (App dev, BTP, Integration, SAP AI)-Senior Manager
$124K - $280K *
Unlock potential by leading SAP application development and integration projects. As a Senior Manager, you'll guide teams through complex challenges, shape solutions, and enhance operational efficienc...
5 days ago
SAP Tech Lead (App dev, BTP, Integration, SAP AI)-Senior Manager
$124K - $280K *
Lead transformative SAP projects, guiding teams through complex integrations and application development. Empower clients with innovative solutions that enhance operational efficiency and align with s...
5 days ago
Sales Manager, Account Executive
$110K - $130K *
Champion a high-performing sales team by driving revenue growth, coaching talent, and executing strategic initiatives. Leverage data insights to enhance performance and foster a culture of accountabil...
5 days ago
Sr. Systems Engineer - Mainframe API Services
$105K - $124K *
Join a team that's driving mainframe API modernization and reliability. Leverage your expertise in IBM z/OS Connect, REST APIs, and automation to enhance system performance and security in a dynamic I...
Reposted 5 days ago
Oracle Financials Solution Architect-Finance to Manage (EBS and Fusion)
$150K - $180K *
Unlock potential by leading Oracle Financials implementations, driving discovery, architecture, and hands-on configuration across multiple engagements. Collaborate with finance teams to deliver tailor...
5 days ago
Clinical Application Specialist, Monitoring
$90K *
Lead the charge in delivering exceptional clinical support and training for patient monitoring systems. Collaborate with teams to ensure timely implementation and ongoing customer satisfaction across...
5 days ago
Oracle Data Migration Architect, Oracle Fusion Cloud and PeopleSoft
$125K - $150K *
Unlock your potential as an Oracle Data Migration Architect, leading complex data conversions from legacy systems to Oracle Fusion Cloud. Collaborate with cross-functional teams to ensure seamless exe...
5 days ago
Senior Database Reliability Engineer
$150K - $190K *
Join a team that's transforming database reliability through innovative architecture and cloud technologies. Collaborate cross-functionally to enhance performance, tackle production issues, and ensure...
5 days ago
$91K - $137K *
Accelerate progress at the forefront of global site start-up activities, managing strategies and coordinating efforts to ensure timely activation. Collaborate with stakeholders and mentor teams to dri...
5 days ago
Senior Program Manager, Employee Experience
$143K - $194K *
Pioneer innovative strategies for a Virtual First work stream, enhancing employee effectiveness through technology and research. Lead cross-functional initiatives, manage complex programs, and drive m...
Reposted 5 days ago
$200K - $225K *
Lead the charge in developing strategies for client retention and growth, optimizing team performance, and building robust client relationships to enhance customer experiences and achieve revenue targ...
Reposted 5 days ago
Telephonic Nurse Case Manager: California RN License (Remote)
$83K - $88K *
Optimize patient care by managing telephonic case management for Workers' Compensation claims. Leverage clinical expertise to ensure timely recovery and return-to-work outcomes while maintaining high...
Reposted 5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.