Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$125K - $150K *

Lead the charge in transforming enterprise security implementations into measurable success. Drive customer outcomes, manage complex programs, and build trusted relationships with executives to ensure...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Join a team that's redefining recruitment by driving innovative strategies, partnering with leaders, and enhancing candidate experiences. You'll own full-cycle recruiting and lead diverse searches in...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Unlock your potential as you drive sourcing and procurement strategies, managing supplier relationships and product development timelines to ensure successful launches and cost-effective solutions in...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$105K - $125K *

Manage client relationships to drive revenue growth and retention. Develop and execute strategies for client engagement, issue resolution, and performance management, collaborating across teams to ens...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$125K - $150K *

Champion the technical integration of partner ecosystems, ensuring seamless onboarding and operational reliability. Drive API discovery, documentation, and troubleshooting while collaborating with int...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a team that's redefining healthcare solutions by leading technical demos and driving enterprise sales. Collaborate with executives to translate needs into impactful presentations, ensuring succes...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K *

Drive the future of project controls by providing expert EVM, cost, and schedule analysis for federal programs. Collaborate with cross-functional teams to enhance decision-making and ensure program co...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Take ownership of client relationships, driving retention and revenue growth through strategic account management and campaign optimization. Leverage expertise in programmatic advertising to ensure cl...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $175K *

Optimize data analytics support for lab production operations by leading a dedicated team in a dynamic environment. Drive innovation, ensure compliance, and enhance operational effectiveness while mak...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $145K *

Empower growth by leveraging your extensive network in Structured Finance to drive new business and revenue. Collaborate across teams to deliver innovative solutions, navigating complex sales cycles w...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$91K - $137K *

Drive site start-up excellence by managing strategies, coordinating activities, and mentoring teams to ensure timely activation and compliance with regulatory requirements in a dynamic environment...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$157K - $185K *

Lead project controls initiatives, balancing technical and people leadership. Oversee major programs, mentor teams, and advise clients while contributing to strategic improvements and governance frame...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$90K - $110K *

Transform project delivery by leading software implementations, ensuring timely and budget-friendly outcomes while fostering strong stakeholder relationships and navigating complex environments with c...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $220K *

Transform your career by leading the product vision for a critical billing module. Collaborate with cross-functional teams to enhance telecom billing systems, ensuring operational efficiency and excep...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$85K - $120K *

Drive security excellence by leveraging technical skills to protect government organizations from advanced threats. Engage in real-time incident response, monitoring, and analysis within a compliance...

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $180K *

Optimize procurement processes and vendor relationships, ensuring effective contract management and risk mitigation in a dynamic technology environment. Collaborate with cross-functional teams to secu...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$113K - $169K *

Elevate healthcare outcomes by leveraging your clinical expertise in a remote role focused on Medicare Part D coverage determinations, appeals, and Medication Therapy Management to enhance member care...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $105K *

Join a team that's shaping water resources projects by leading engineering design and project management, ensuring client satisfaction through innovative solutions and strategic planning across divers...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$88K - $105K *

Execute engineering project management for water resources, overseeing project lifecycle, client liaison, and team coordination to ensure on-time, on-budget delivery of high-quality outcomes for munic...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$90K - $120K *

Contribute to enhancing fraud detection systems across diverse product lines. Investigate fraud cases, analyze complex data, and collaborate with teams to optimize operations while balancing customer...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$160K - $170K *

Lead a dynamic sales team to drive innovative HIV treatment strategies. Collaborate with healthcare professionals to develop actionable business plans, foster key relationships, and achieve performanc...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$134K - $162K *

Lead the charge in advancing clinical adoption and workflow optimization for radiopharmaceutical products. Collaborate cross-functionally to ensure safe, compliant practices while building strategic r...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$170K - $200K *

Champion operational excellence by leading business unit strategies, enhancing performance management, and driving cross-functional collaboration to achieve enterprise goals and scalable solutions...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $160K *

Champion customer success by leading enterprise deployments and integrations. Drive technical direction and enhance automation for cloud services, ensuring seamless operations and improved customer ex...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$71K - $125K *

Transform client relationships by supporting sales and credit functions, managing lending processes under $10M, and ensuring data integrity. Collaborate with teams to create impactful pitch materials...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.