Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$150K - $180K *

Lead the charge in transforming organizational culture and effectiveness by partnering with senior leaders to embed impactful behaviors and practices. Drive measurable change and foster collaboration...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$140K - $175K *

Join a team that's shaping security and compliance across the company. You'll lead HITRUST and SOC 2 programs, ensuring data protection while collaborating with engineering and legal teams in a hands...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$350K - $425K *

Join a team that's redefining cybersecurity by leading product marketing strategy, driving growth, and shaping market narratives. Collaborate with executives to influence product direction and elevate...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Information Technology

$95K - $115K *

Empower your career by managing diverse Cybersecurity projects from initiation to completion. Collaborate with teams, engage clients, and ensure project success through effective planning and executio...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Engage with cross-functional teams to shape and execute go-to-market strategies for AI-powered products, translating customer needs into compelling narratives that drive adoption, awareness, and reven...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$155K - $410K *

Advance SAP technology initiatives by leading S/4 migrations, application development, and cloud transformations. Drive strategic direction, mentor teams, and enhance client relationships to improve o...

5 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$155K - $410K *

Accelerate your career by leading SAP technology initiatives, driving S/4 migrations, and shaping client strategies. Mentor teams, enhance operational efficiency, and build executive relationships whi...

5 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$100K - $231K *

Unlock potential by leading strategic capture management initiatives, collaborating with cross-functional teams to enhance proposal quality and win probability in Medicaid managed care. Drive innovati...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $185K *

Unlock potential by driving growth and adoption of innovative purification technologies in the bioprocessing market. Collaborate with cross-functional teams to expand customer base and enhance market...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$105K - $115K *

Empower innovation as a VTOC Operations Specialist, designing and maintaining advanced AV systems. Collaborate with users to ensure optimal performance and support cutting-edge solutions for our intel...

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $159K *

Join our team to drive software design assurance for innovative cloud-based and AI/ML systems. Collaborate with cross-functional teams to ensure compliance with global regulations and enhance product...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Join a dynamic team to oversee CMMC compliance, ensuring strategic coordination across stakeholders and technical teams. Drive project execution, monitor KPIs, and facilitate continuous improvement in...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$170K - $190K *

Elevate student success by leading innovative marketing strategies for a nationwide education program. Drive engagement and growth through collaboration, creativity, and data-driven decision-making wh...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$150K - $186K *

Champion the design and implementation of scalable order management systems, driving technical excellence and collaboration across teams to enhance client trust and operational efficiency in a dynamic...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$78K - $95K *

Join a team that's shaping the future of ICT design for commercial buildings. Collaborate with senior engineers to produce low voltage system designs, manage project deliverables, and enhance your ski...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Technical Services

$90K - $110K *

Empower nursing excellence by leading clinical operations and quality initiatives. Drive resident outcomes and foster a collaborative culture while ensuring compliance and staff development in a dynam...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $140K *

Optimize pricing strategies by leading MAC management for enterprise clients. Collaborate with cross-functional teams to ensure accurate pricing, monitor performance, and develop solutions. Drive team...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$102K - $148K *

Help us deliver exceptional customer experiences by leading technical implementations and training for our product suite. Collaborate with cross-functional teams to ensure successful deployments and e...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$250K - $300K *

Lead the charge in shaping the future of AI Services, driving strategy, execution, and operational excellence across innovative AI-driven initiatives while collaborating with cross-functional teams to...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$155K - $306K *

Drive exceptional M&A outcomes by leading engagements that optimize client integration or divestiture strategies. Leverage your expertise in transaction execution to maximize value during critical M&A...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$170K - $200K *

Accelerate growth by leading assurance services for financial institutions, driving client relationships, ensuring audit quality, and developing future leaders while enhancing market presence and prac...

5 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$100K - $120K *

Empower Customer Success by driving strategy and data insights to enhance customer outcomes. Collaborate with cross-functional teams to optimize processes, support growth, and ensure exceptional custo...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $130K *

Join a team that's driving strategic sales initiatives within Fortune 500 accounts. Leverage your expertise in networking and prospecting to create a robust pipeline and collaborate closely with Accou...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$132K - $193K *

Join a dynamic team to design and implement custom integrations, enhancing customer experiences with AI-driven solutions. Collaborate closely with clients to solve complex technical challenges and dri...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$180K - $220K *

Accelerate progress at a dynamic technology firm by leading revenue growth, developing sales strategies, and building a high-performing team driving sustainable success in the cybersecurity landscape...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.