Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$190K - $305K *

Join a team that's shaping healthcare by providing legal guidance on regulatory matters, employee benefits, and AI initiatives. As a senior contributor, you'll lead complex reviews, manage risks, and...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$162K - $192K *

Lead strategic sales initiatives and manage P&L for MCC, driving growth through vendor contracts and financial oversight while executing the Commercial Strategic Plan and ensuring alignment with site...

Today

  •   8 - 10 years exp.  •   Food & Beverages

$155K - $170K *

Lead the charge in shaping enterprise business solutions through hands-on architecture and delivery in Microsoft Dynamics 365 Finance & Operations, focusing on integration, process optimization, and o...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Staffing

$140K - $150K *

Lead the charge in nationwide Cybersecurity Disaster Recovery and Contingency Planning initiatives, providing strategic oversight and technical expertise to enhance organizational resilience and ensur...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Staffing

$105K - $127K *

Champion transformative patient experience strategies by leveraging data insights to drive high-impact initiatives. Collaborate with C-suite executives and healthcare providers to enhance operational...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Lead the development of enterprise-grade applications using Java, Python, and AI technologies. Collaborate with cross-functional teams to design and implement robust software solutions in a dynamic, A...

Today

  •   5 - 7 years exp.  •   Staffing

$183K - $190K *

Unlock your potential by leading SAP GTS projects, designing solutions, and driving customer success. Collaborate with teams to deliver innovative implementations and enhance business processes while...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $190K *

Lead the charge in ensuring compliance for medical devices by managing audits, reviewing documentation, and collaborating with clients. Utilize your expertise in regulatory frameworks to drive quality...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Technical Services

$185K - $215K *

Take ownership of analytical development initiatives, ensuring compliance, accuracy, and high-quality documentation for multiple projects. Collaborate closely with internal teams and external partners...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $250K *

Take ownership of comprehensive fraud risk management across consumer and small business segments. Lead detection frameworks, analyze fraud patterns, and collaborate cross-functionally to enhance prod...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Unlock your potential as you lead strategic sales initiatives within the DoD, cultivating relationships and closing new business to meet or exceed your quotas while managing a defined territory and co...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$180K - $225K *

Transform the claims process by building robust event-driven systems. As a key player, you'll design, implement, and maintain backend services, ensuring reliability and efficiency while mentoring fell...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$160K - $220K *

Optimize market operations by managing risk and ensuring compliance in trade processes. You'll monitor performance, resolve client issues, and drive operational improvements to safeguard trading integ...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $123K *

Lead the charge in pharmaceutical meetings operations, driving client partnerships and operational excellence while navigating compliance. Shape processes and enhance stakeholder engagement to deliver...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Transportation

$180K - $220K *

Transform enterprise AI partnerships by leading strategic growth initiatives, enhancing relationships, and driving revenue across key Google organizations. Leverage your expertise in AI, cloud, and di...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Drive innovative experiential solutions by leading creative teams to design impactful business events. Collaborate with clients to craft engaging experiences that align with strategic objectives, ensu...

Today

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Champion strategic partnerships and drive revenue growth through effective channel management and collaborative business planning, ensuring sales success and partner satisfaction while navigating comp...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$120K - $247K *

Unlock potential by leading complex digital production across diverse platforms, ensuring seamless execution of business and creative strategies. Collaborate with cross-functional teams to deliver imp...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Consumer Technology

$130K - $155K *

Join a dynamic team to lead software initiatives, driving architectural decisions and optimizing delivery. Collaborate with stakeholders to align technology solutions with business objectives while fo...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Healthcare

$135K - $160K *

Lead the charge in delivering hands-on technical solutions for pharma clients, coordinating with teams to ensure successful project execution and measurable business impact while fostering collaborati...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$96K - $166K *

Lead the enhancement and scaling of Adobe Experience Platform solutions, ensuring optimal data governance and architecture across digital ecosystems. Collaborate with cross-functional teams to achieve...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$114K - $218K *

Transform customer relationships and lead enterprise sales initiatives while driving innovative GIS solutions in state government markets. Collaborate with teams to meet revenue goals and foster profe...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$160K - $210K *

Transform healthcare communications by strategizing and executing impactful media outreach, building relationships, and crafting compelling narratives that resonate with consumers and industry leaders...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$135K - $160K *

Shape the future of secure, scalable backend systems as a hands-on leader. Design and guide a team while writing Golang code for critical distributed services serving millions. Drive performance and p...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Join a team that's redefining enterprise data management by leading cross-functional initiatives, ensuring data reliability, and driving strategic insights through advanced program management and tech...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.