Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $90K *

Shape the future of integrated marketing strategies by owning the creative process from ideation to execution. Collaborate with teams to deliver impactful campaigns that drive performance and renewals...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Media

$120K - $150K *

Advance your career by leading a dynamic NICU team, ensuring high-quality patient care and fostering collaboration among medical staff. Drive operational excellence and strategic initiatives in a comp...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$144K - $180K *

Join a team that's redefining healthcare affordability by leading strategic initiatives to enhance cost management and improve quality outcomes across the organization. Collaborate with diverse teams...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Join a team that's committed to enhancing Epic Willow workflows. Use your expertise to provide top-tier application support and optimization while collaborating with stakeholders to ensure stability a...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$250K - $290K *

Elevate your career by leading a high-performing engineering team, driving strategy and innovation in web3 technologies. Shape the future of decentralized systems while ensuring top-tier security and...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$84K - $115K *

Transform maintenance operations by leading electrical and mechanical teams, enhancing methodologies, and ensuring equipment reliability while fostering a culture of safety and compliance across the p...

5 days ago

  •   Less than 5 years exp.  •   Business Services

$133K - $262K *

Unlock potential by developing AI-driven solutions that enhance business processes and integrate with enterprise systems. Collaborate with clients and teams to shape the future of finance and accounti...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$157K - $174K *

Drive impactful media strategies and foster PR excellence across U.S. and Israel. Collaborate with leadership to establish authority in AI security and exposure management while utilizing innovative A...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$161K - $210K *

Elevate workforce management by leading recruitment, onboarding, and performance strategies. Drive clinician readiness and productivity while ensuring quality care through data-driven decision-making...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $103K *

Discover a rewarding role as you coordinate individualized hospice care, assess patient needs, and collaborate with a dedicated care team to enhance quality of life through compassionate support and t...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$67K - $100K *

Champion afterhours hospice care by providing urgent, compassionate support to patients and families. Conduct evaluations, triage needs, and ensure comprehensive care delivery in diverse home environm...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$105K - $160K *

Inspire excellence in outpatient coding management by leading a dynamic team, optimizing processes, and achieving departmental goals in a fast-paced, patient-focused environment. Join us in enhancing...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$114K - $167K *

Shape the future of enterprise finance by leading SAP S/4HANA transformations, optimizing processes, and guiding complex integrations. Collaborate with teams to ensure compliance and deliver high-qual...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Take ownership of operational excellence across multiple locations, driving growth and developing high-performing teams while ensuring compliance, safety, and client satisfaction to achieve strategic...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$115K - $194K *

Empower our Solutions Architects by enhancing operational tools and workflows. Drive efficiency and effectiveness in customer engagement processes, ensuring data quality and reporting standards are me...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$189K - $247K *

Empower inventory excellence by optimizing forecasting and replenishment strategies to enhance performance and drive ROI. Collaborate across teams to create data-driven solutions for rapid growth and...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$107K - $213K *

Lead the charge in site activation for clinical research projects, ensuring timely and compliant start-up. Collaborate cross-functionally to manage risks, mentor teams, and drive operational excellenc...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$210K - $250K *

Discover a rewarding opportunity to serve as a clinical diagnostic radiologist, providing essential patient care and diagnostic imaging services while engaging in educational responsibilities and admi...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Lead the charge in delivering advanced AI-powered solutions using Python. Collaborate with cross-functional teams to tackle complex challenges and drive innovation in Generative AI across diverse proj...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$123K - $169K *

Elevate your career by providing strategic oversight for licensing, enrollment, and credentialing operations. Lead initiatives that ensure compliance and enhance organizational capabilities while coll...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock insights by developing and maintaining Power BI dashboards that drive strategic decision-making. Collaborate with stakeholders and data teams to transform raw data into impactful visualizations...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$92K - $110K *

Champion compliance excellence by overseeing audits and monitoring activities. Collaborate with teams to ensure adherence to regulatory standards and drive remediation efforts, enhancing integrity acr...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$86K - $104K *

Transform training excellence by leading regional learning initiatives, ensuring effective execution and adherence to brand standards. Engage with teams to foster a culture of continuous improvement a...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$94K - $118K *

Transform knowledge management by leading a team to enhance content delivery, improve operational efficiency, and leverage AI solutions. Collaborate across functions to create accessible information t...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Join a team that's dedicated to providing tailored portfolio solutions for high net worth and institutional clients, leveraging advanced investment strategies and strong analytical skills to navigate...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.