Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$122K - $338K *

Lead transformative Oracle solutions that enhance supply chain and business operations. Collaborate with clients to design scalable architectures, ensuring seamless integration across various Oracle a...

5 days ago

  •   8 - 10 years exp.  •   Business Services

$122K - $187K *

Unlock potential by driving sales growth in the Mid-Market Direct segment, engaging with leading AWS clients and leveraging cloud technology solutions to meet industry needs and achieve sales targets...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Business Services

$141K - $278K *

Advance operational excellence by leading MES initiatives, enhancing production efficiency, and driving digital transformation across manufacturing processes. Collaborate with teams to implement innov...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$141K - $278K *

Pioneer advanced Manufacturing Execution Systems solutions. Lead design, implementation, and continuous improvement initiatives across diverse client environments. Collaborate to drive operational exc...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$87K - $253K *

Champion integrated, multi-function operating models for Global Capability Centers. Drive operational excellence and scalable solutions by leveraging cross-functional expertise and innovation to align...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$135K - $160K *

Lead the charge in driving operational excellence and market growth. As a senior leader, you'll oversee performance, customer relationships, and team development, ensuring alignment with strategic goa...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$141K - $278K *

Advance MES solutions by leading discussions, gathering requirements, and delivering scalable implementations in a dynamic environment. Collaborate with technical architects to drive innovation and ef...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$141K - $278K *

Join a team that's driving digital transformation in manufacturing. Lead MES initiatives to enhance operational excellence, streamline processes, and foster innovation across production and supply cha...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Unlock potential by joining our dynamic team to build robust back-end systems that power AI-driven workflows and enhance user experiences across platforms. Collaborate with engineers to innovate and s...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$115K - $151K *

Grow your career with a dynamic team focused on AI tool administration and governance. Collaborate across departments to enhance system connectivity and process automation while ensuring data privacy...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$115K - $194K *

Engage with the developer community as you advocate for our platform, creating compelling content, conducting demos, and gathering feedback to enhance product features, all while building relationship...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$112K - $196K *

Champion a people-first culture while leading a talented team in proposal operations. Collaborate with diverse stakeholders to drive strategic pursuits and create impactful proposals that set the orga...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$88K - $154K *

Advance your career by leading process engineering for semiconductor projects. Collaborate with cross-functional teams to optimize systems, ensuring compliance with industry standards while mentoring...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead the charge in establishing a standardized implementation methodology, overseeing complex projects from contract to go-live. Drive team adoption, manage dependencies, and ensure successful transit...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$300K - $350K *

Join a collaborative cardiology team providing exceptional patient care in a high-volume practice. Enjoy a flexible schedule, strong referral base, and opportunities for professional growth within a p...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Drive your career with a pivotal role in optimizing Epic Willow Ambulatory applications, enhancing pharmacy operations through strategic collaboration, innovative solutions, and robust system manageme...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $120K *

Lead a diverse portfolio of clients as a Tax Manager, overseeing compliance and planning while mentoring your team. Enjoy autonomy in client relationships and contribute to a culture of high-quality s...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$120K - $145K *

Empower regional marketing efforts by executing plans that engage key thought leaders and capitalize on local opportunities, driving success in hematology and oncology markets while collaborating with...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Transform fragmented IT landscapes as you lead complex service integration projects, improving data flow and visibility across hybrid cloud and on-premise environments. Guide cross-functional teams an...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $135K *

Lead the charge in driving strategic project delivery across multiple squads, ensuring alignment with business priorities and effective communication among stakeholders. Utilize program management exp...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Oversee the successful implementation of Smart Communications solutions, ensuring timely delivery, budget compliance, and high client satisfaction by mentoring junior staff, managing projects, and fac...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$94K - $141K *

Shape the future of software delivery by crafting compelling messaging and positioning for regulated enterprises. Drive executive conversations with insights on compliance and AI governance, while equ...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Champion operational excellence by leading logistics teams to enhance efficiency, safety, and quality. Drive performance through effective management and motivation, ensuring seamless coordination and...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Transportation

$304K - $397K *

Transform strategic account growth by developing relationships and executing sales plans. Leverage AI insights to enhance client engagement and drive revenue through consultative selling and multi-yea...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$73K - $107K *

Elevate your engineering career by providing design and technical support for water utility projects, ensuring compliance and optimal functionality while managing capital improvements and engaging wit...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.