Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Oracle Supply Chain Management Solution Architect, Senior Manager
$122K - $338K *
Lead transformative Oracle solutions that enhance supply chain and business operations. Collaborate with clients to design scalable architectures, ensuring seamless integration across various Oracle a...
5 days ago
AWS Edge Mid-Market Sales Senior Executive
$122K - $187K *
Unlock potential by driving sales growth in the Mid-Market Direct segment, engaging with leading AWS clients and leveraging cloud technology solutions to meet industry needs and achieve sales targets...
Reposted 5 days ago
$141K - $278K *
Advance operational excellence by leading MES initiatives, enhancing production efficiency, and driving digital transformation across manufacturing processes. Collaborate with teams to implement innov...
Reposted 5 days ago
MES Solution Architect Manager (iBase-t Solumina)
$141K - $278K *
Pioneer advanced Manufacturing Execution Systems solutions. Lead design, implementation, and continuous improvement initiatives across diverse client environments. Collaborate to drive operational exc...
Reposted 5 days ago
Global Capability Center Strategy & Design Lead
$87K - $253K *
Champion integrated, multi-function operating models for Global Capability Centers. Drive operational excellence and scalable solutions by leveraging cross-functional expertise and innovation to align...
Reposted 5 days ago
General Manager - Marick Mechanical (St. Louis, MO)
$135K - $160K *
Lead the charge in driving operational excellence and market growth. As a senior leader, you'll oversee performance, customer relationships, and team development, ensuring alignment with strategic goa...
Reposted 5 days ago
MES Solution Architect Manager (iBase-t Solumina)
$141K - $278K *
Advance MES solutions by leading discussions, gathering requirements, and delivering scalable implementations in a dynamic environment. Collaborate with technical architects to drive innovation and ef...
Reposted 5 days ago
$141K - $278K *
Join a team that's driving digital transformation in manufacturing. Lead MES initiatives to enhance operational excellence, streamline processes, and foster innovation across production and supply cha...
Reposted 5 days ago
Software Engineer, Back-End - Mail (US)
$125K - $150K *
Unlock potential by joining our dynamic team to build robust back-end systems that power AI-driven workflows and enhance user experiences across platforms. Collaborate with engineers to innovate and s...
Reposted 5 days ago
AI Administrator, Business Applications
$115K - $151K *
Grow your career with a dynamic team focused on AI tool administration and governance. Collaborate across departments to enhance system connectivity and process automation while ensuring data privacy...
Reposted 5 days ago
$115K - $194K *
Engage with the developer community as you advocate for our platform, creating compelling content, conducting demos, and gathering feedback to enhance product features, all while building relationship...
Reposted 5 days ago
Proposal Operations Manager (US Central Region)
$112K - $196K *
Champion a people-first culture while leading a talented team in proposal operations. Collaborate with diverse stakeholders to drive strategic pursuits and create impactful proposals that set the orga...
Reposted 5 days ago
Sr. Process Engineer - Semi Conductor
$88K - $154K *
Advance your career by leading process engineering for semiconductor projects. Collaborate with cross-functional teams to optimize systems, ensuring compliance with industry standards while mentoring...
5 days ago
$110K - $130K *
Lead the charge in establishing a standardized implementation methodology, overseeing complex projects from contract to go-live. Drive team adoption, manage dependencies, and ensure successful transit...
Reposted 5 days ago
Non-Invasive Cardiologist - Established Practice - 1:6 Call - St. Louis, MO
$300K - $350K *
Join a collaborative cardiology team providing exceptional patient care in a high-volume practice. Enjoy a flexible schedule, strong referral base, and opportunities for professional growth within a p...
5 days ago
$85K - $100K *
Drive your career with a pivotal role in optimizing Epic Willow Ambulatory applications, enhancing pharmacy operations through strategic collaboration, innovative solutions, and robust system manageme...
Reposted 5 days ago
$80K - $120K *
Lead a diverse portfolio of clients as a Tax Manager, overseeing compliance and planning while mentoring your team. Enjoy autonomy in client relationships and contribute to a culture of high-quality s...
Reposted 5 days ago
Associate Director, Regional Marketing (Mid-Atlantic Region)
$120K - $145K *
Empower regional marketing efforts by executing plans that engage key thought leaders and capitalize on local opportunities, driving success in hematology and oncology markets while collaborating with...
Reposted 5 days ago
Lead Service Integration Engineer
$120K - $145K *
Transform fragmented IT landscapes as you lead complex service integration projects, improving data flow and visibility across hybrid cloud and on-premise environments. Guide cross-functional teams an...
Reposted 5 days ago
Advanced Specialist, Project Management
$125K - $135K *
Lead the charge in driving strategic project delivery across multiple squads, ensuring alignment with business priorities and effective communication among stakeholders. Utilize program management exp...
Reposted 5 days ago
Professional Services Consultant
$95K - $115K *
Oversee the successful implementation of Smart Communications solutions, ensuring timely delivery, budget compliance, and high client satisfaction by mentoring junior staff, managing projects, and fac...
Reposted 5 days ago
Sr. Product Marketing Specialist
$94K - $141K *
Shape the future of software delivery by crafting compelling messaging and positioning for regulated enterprises. Drive executive conversations with insights on compliance and AI governance, while equ...
Reposted 5 days ago
$80K - $95K *
Champion operational excellence by leading logistics teams to enhance efficiency, safety, and quality. Drive performance through effective management and motivation, ensuring seamless coordination and...
Reposted 5 days ago
Senior Strategic Account Executive (Accounts 1 billion+)
$304K - $397K *
Transform strategic account growth by developing relationships and executing sales plans. Leverage AI insights to enhance client engagement and drive revenue through consultative selling and multi-yea...
Reposted 5 days ago
$73K - $107K *
Elevate your engineering career by providing design and technical support for water utility projects, ensuring compliance and optimal functionality while managing capital improvements and engaging wit...
Reposted 5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.