Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Bilingual Virtual Clinical Educator
$58K - $108K *
Join a team that's dedicated to enhancing patient experiences through compassionate support and education in Hepatology. Engage with patients and caregivers, providing vital resources and guidance thr...
Today
$105K - $135K *
Lead financial planning and analysis efforts, partnering with business leaders to drive strategic insights, enhance decision-making, and improve operational excellence through data-driven financial mo...
Today
$96K - $115K *
Lead the charge in designing and developing aerospace wire harnesses, ensuring compliance with industry standards while collaborating with multidisciplinary teams to deliver innovative solutions...
Reposted today
Sr. Account Manager - Construction
$114K - $218K *
Transform the construction industry by leveraging geospatial technology to enhance customer relationships and optimize strategies for growth. Collaborate with experts and use your industry insights to...
Reposted today
Backend Software Engineer - TS/SCI
$97K - $162K *
Innovate backend solutions for critical national security missions, developing APIs and data capabilities in cloud environments. Collaborate with Defense and Intelligence sectors to solve complex tech...
Reposted today
Lead Specialist, Technical Architect
$150K - $160K *
Partner with us to shape the quality strategy for a leading exam development platform. Leverage your expertise to guide multiple Agile teams, enhance automation practices, and ensure high standards ac...
Reposted today
$90K - $110K *
Optimize product operations by driving launches, enhancing documentation, and improving customer experiences. Collaborate with cross-functional teams to ensure seamless feature adoption and leverage c...
Today
$187K - $243K *
Engage in building and scaling systems that serve millions. As a seasoned engineer, influence technical decisions, foster AI adoption, and lead projects from concept to deployment while collaborating...
Reposted today
SAP PI/PO Developer - 100% Onsite in St. Louis, MO
$91K - $178K *
Unlock seamless integration across complex systems by architecting and developing SAP solutions. Lead a team in delivering high-quality technical documentation and best practices while ensuring compli...
Reposted today
$95K - $115K *
Elevate your career by owning IT operations, enhancing security, and automating workflows in a fully remote environment. Collaborate with teams to resolve complex issues and streamline processes while...
Reposted today
Remote Construction Program Manager
$133K - $200K *
Champion the delivery of advanced manufacturing capabilities by leading cross-functional teams, managing project lifecycles, and ensuring alignment with customer and stakeholder expectations for succe...
Today
Partnerships Manager, Legal Tech (Bar Associations Program)
$110K - $135K *
Join us in shaping innovative partner programs aimed at enhancing legal collaboration. This strategic role demands creativity and leadership, managing bar association relations to propel growth and su...
Reposted today
$120K - $145K *
Empower your career by leading data architecture initiatives across Oracle Cloud applications. Drive data governance, migration, and integration strategies to enhance business processes and ensure dat...
Reposted today
Quantitative Analyst - Prediction Markets
$110K - $130K *
Unlock potential by driving research in prediction markets, developing alpha signals, and collaborating through the entire model implementation process. Guide projects from data analysis to live tradi...
Reposted today
Sr. Manager, People Technology & Analytics
$132K - $194K *
Unlock potential by leading the strategy and evolution of People technology and analytics. Drive data governance and insights to enhance decision-making and operational efficiency, while partnering wi...
Reposted today
Sr Paid Search Strategist (Enterprise)
$75K - $90K *
Drive impactful SEM strategies to enhance online visibility and conversions. Collaborate with diverse clients, analyze data, and optimize campaigns to exceed goals while staying ahead of industry tren...
Today
Director, Social Commerce Strategy
$125K - $150K *
Unlock potential by leading social commerce strategies across platforms like TikTok, Instagram, and YouTube. Drive revenue growth and optimize customer experiences through innovative, data-driven appr...
Reposted today
AS/400 SYNON/RxClaim Tech Lead | Remote | 6+ Months
$110K - $130K *
Unlock potential by leading development initiatives in healthcare technology, focusing on SYNON and AS400 systems. Collaborate with teams to deliver high-quality solutions for pharmacy benefits and cl...
Today
$125K - $150K *
Transform financial operations by leading accounting, reporting, and FP&A. Drive efficiency through AI integration, manage audits, and build scalable processes while supporting strategic growth initia...
Today
Regional Sales Director - Long Island
$180K - $215K *
Inspire growth by leading regional launch strategies and building high-performing sales teams. Drive market success through strong customer relationships and cross-functional collaboration in a fast-p...
Reposted today
Senior Medical Science Liaisons (MSL) - Cardiovascular, Florida
$215K - $240K *
Drive scientific engagement as a Senior Medical Science Liaison, fostering relationships with Key Opinion Leaders and healthcare professionals. Leverage your expertise in cardiovascular disease to sup...
Reposted today
Regional Sales Director - Nashville
$180K - $215K *
Transform your career by leading regional sales efforts, driving product launch success, and building high-performing teams. Collaborate cross-functionally to achieve sales goals and foster strong cus...
Reposted today
Staff Software Engineer - Files Platform
$158K - $248K *
Unlock potential by architecting scalable file management solutions, integrating distributed systems, and ensuring secure access for enterprise customers. Collaborate across teams to enhance data acce...
Reposted today
Sr. Security Operations Manager
$172K - $269K *
Lead and modernize global security operations, managing a distributed team while enhancing detection strategies and incident response. Drive AI integration for efficiency and ensure accountability thr...
Reposted today
Head of Product and Solutions Marketing
$179K - $280K *
Shape the future of product marketing by leading a dynamic team focused on innovation, market resonance, and compelling narratives to drive product adoption and growth in a fast-paced environment...
Reposted today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.