Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$168K - $238K *

Drive proactive security architecture strategies to enhance software resilience, collaborating with engineering teams to embed security into development workflows while minimizing manual intervention...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$231K - $301K *

Lead the charge in compliance strategy for U.S. Commercial and Market Access. Collaborate with senior leaders to guide complex compliance issues, manage risks, and support innovative business objectiv...

United StatesRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Engage with key decision-makers to drive growth in mid-market accounts. Take ownership of the full sales cycle, leveraging your expertise to build a robust pipeline and shape the sales strategy in a d...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$169K - $255K *

Shape the future of personalized consumer products by driving strategic partnerships and revenue growth. Lead business development efforts, cultivate relationships, and expand market reach to position...

United StatesRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$118K - $148K *

Drive targeted ABM campaigns that engage priority accounts and enhance pipeline growth. Own strategy, execution, and optimization across multiple channels, collaborating with Sales and Marketing teams...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Optimize data product delivery by collaborating with stakeholders to define roadmaps, manage backlogs, and drive adoption. Leverage analytics and engineering expertise to ensure high-quality, impactfu...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Technical Services

$159K - $235K *

Join us to lead a dynamic team in B2B retention marketing, driving engagement and success for Advertisers and DoorDash for Business customers through innovative CRM strategies and personalized campaig...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$150K - $180K *

Lead the charge in optimizing sales incentive compensation programs, overseeing administration, governance, and continuous improvement. Collaborate cross-functionally to ensure timely processing and a...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Join our team to drive growth by reactivating lapsed accounts and expanding our advertising measurement solutions across various sectors. This sales-focused role combines prospecting and program manag...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Media

$146K - $229K *

Unlock potential by leading a high-accountability engineering team to architect and deliver innovative data products, enabling analytics and AI while fostering a culture of quality and collaboration a...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $145K *

Engage with us to lead full lifecycle recruiting across diverse functions, ensuring a high-quality candidate experience. Collaborate with hiring managers to adapt strategies and maintain operational e...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$52K - $132K *

Champion the future of healthcare integration by resolving complex technical issues, analyzing architectures, and collaborating with teams to enhance interoperability in mission-critical environments...

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$70K - $111K *

Take ownership of Oracle EBS Project Accounting operations, enhancing project costing, billing, and financial processes. Collaborate with diverse teams to document workflows and improve operational re...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$172K - $215K *

Drive clinical development strategies for early cancer detection, overseeing rigorous study design and execution. Collaborate with stakeholders to ensure high-quality data delivery that impacts patien...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$129K - $147K *

Champion innovative digital video strategies, focusing on CTV, while leading cross-functional teams to optimize campaign performance and drive growth in a dynamic advertising environment...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Media

$80K - $101K *

Transform your career with a role that offers flexible schedules, competitive pay, and a supportive team environment. Enjoy 100% outpatient care with hybrid options, focusing on patient excellence and...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $101K *

Grow your career as a Licensed Therapist, providing essential outpatient care with flexible scheduling and competitive compensation. Join a supportive team dedicated to patient excellence and work-lif...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $101K *

Elevate patient care by providing expert therapy services in a flexible, supportive environment. Enjoy autonomy over your schedule while collaborating with a dedicated team to enhance mental health ou...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Empower teams by managing transportation projects. Lead client engagement, develop proposals, and ensure quality. Leverage your experience with Missouri DOT to enhance project success and foster relat...

Reposted 5 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$112K - $135K *

Transform the future of cloud solutions by leading DevOps initiatives, enhancing automation, and collaborating across teams to streamline application onboarding and deployment processes in a dynamic...

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$85K - $90K *

Shape the future of production operations by leading a dynamic team to ensure safety, efficiency, and quality. Drive continuous improvement while managing schedules, performance, and compliance in a f...

5 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$110K - $130K *

Engage in comprehensive pharmaceutical services, promoting safe medication therapy. Oversee the medication use system and collaborate with medical staff to ensure effective treatment and enhance patie...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Lead complex advisor transitions end-to-end, ensuring seamless onboarding and process improvements while managing a team and enhancing operational efficiency in a fast-paced environment...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Lead flight operations as a Direct Entry Captain, ensuring safety, compliance, and effective crew management while representing company values in a dynamic environment...

United StatesRemote

5 days ago

  •   15+ years exp.  •   Transportation

$93K - $450K *

Grow your career by connecting with investors and building a strong client base. Match clients with exclusive properties while benefiting from expert training, performance incentives, and a supportive...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.