Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$140K - $160K *
Advance the design and implementation of a robust knowledge architecture for K-12 assessment systems, integrating AI and learning science to enhance educational outcomes through innovative, data-drive...
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Senior, Influencer Manager - Creative - US Remote
$85K - $115K *
Transform creator-driven ideas into high-quality deliverables by managing influencer campaigns, coordinating production workflows, and ensuring compliance across multiple platforms. Collaborate with c...
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$103K - $181K *
Join us to lead high-impact programs and projects, driving strategic initiatives and enhancing performance through data analysis and cross-functional collaboration. Your expertise will guide teams and...
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ARPA-H Senior Scientist / Engineer (Regenerative Medicine & Advanced Biological Systems)
$125K - $185K *
Elevate health outcomes by collaborating on innovative R&D initiatives, supporting program development, and integrating advanced biological systems with cutting-edge technologies in a dynamic, remote...
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Director, Consumer Marketing & Strategy
$162K - $211K *
Join a team that's redefining consumer marketing strategies in healthcare. Drive impactful initiatives that enhance patient engagement and awareness while collaborating across functions to shape the f...
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Early Phase Clinical Project Manager
$110K - $130K *
Join a team that's dedicated to leading interdisciplinary clinical research projects, ensuring compliance with regulatory standards, and delivering quality results on time and within budget while fost...
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$104K - $200K *
Advance partner program effectiveness by managing operations, improving processes, and delivering insights. Collaborate with cross-functional teams to enhance the partner ecosystem and drive strategic...
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Executive Director, MISUMI Imprint Foundation
$215K - $250K *
Build your career with a pioneering role to shape grantmaking, partner programs, and organizational independence. Lead initiatives, engage stakeholders, and measure success while establishing a founda...
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Associate Director/Director Process Chemistry
$177K - $205K *
Lead the charge in advancing drug substance processes by collaborating with CDMOs and internal teams to ensure timely delivery and adherence to regulatory standards, while providing technical expertis...
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Director, Brand Marketing - SWTHZ
$110K - $130K *
Elevate the SWTHZ brand by leading PR, partnerships, and social strategies. Collaborate with creative teams to craft a compelling narrative, engage communities, and drive brand recognition through inn...
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$90K - $105K *
Innovate Salesforce solutions to enhance global operations, translating business needs into effective strategies. Collaborate with teams to optimize user experience and drive revenue growth through ad...
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Account Executive - Healthcare
$200K - $255K *
Elevate your career by driving new business in healthcare accounts. Engage with C-level executives, navigate complex sales cycles, and close high-value deals to expand market presence and achieve reve...
Reposted today
Internal Business Systems Consultant
$86K - $138K *
Empower your career by leading business analysis efforts, collaborating with stakeholders to enhance system applications, and driving innovative solutions that improve operational efficiency and user...
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Senior Software Engineer - Machine Learning Platform
$166K - $230K *
Innovate and enhance the machine learning infrastructure to empower rapid model deployment and automation. Collaborate across teams to streamline operations and drive impactful solutions in ML and fin...
Reposted today
Account Executive - Midwest / Central
$80K - $95K *
Join a dynamic sales team to drive growth in K-12 education, managing the full sales cycle and building strategic partnerships. Shape your territory strategy while enhancing digital learning environme...
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$94K - $111K *
Unlock potential by joining our post-acute care team, providing high-quality care in skilled nursing facilities. Collaborate with a multidisciplinary team, enjoy autonomy, and benefit from comprehensi...
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Senior Director, Oncology Communications
$166K - $244K *
Lead the Oncology narrative and media strategy, driving impactful communications across channels. Collaborate with cross-functional teams to enhance brand presence and storytelling, ensuring alignment...
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$110K - $130K *
Elevate the effectiveness of product vulnerability management by owning processes, driving automation, and collaborating closely with engineering. Be the key point of accountability for reducing risk...
Reposted today
Sr Software Development Engineer
$120K - $145K *
Join a team that's dedicated to solving complex software challenges. As a Sr. Software Engineer, you'll design, build, and maintain robust applications while collaborating across teams to enhance our...
Reposted today
Principal Software Security Architect
$150K - $180K *
Join a team that's redefining the future by leveraging cutting-edge AI to develop innovative machine learning solutions that solve complex business challenges, and actively collaborating across multid...
Reposted today
$110K - $130K *
Engage with cross-functional teams to shape and deliver innovative classroom experiences. Take ownership of user-facing features and backend services, ensuring alignment with market needs and enhancin...
Reposted today
Software Development Engineer, Data and Analytics
$143K - $194K *
Elevate software development by designing and deploying distributed open-source message broker systems. Collaborate with cross-functional teams to drive architecture and best practices while mentoring...
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$95K - $115K *
Join us to design and deliver innovative mechanical systems for heavy industrial thermal processes. Collaborate with cross-functional teams, mentor junior engineers, and tackle complex challenges in a...
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Staff Data Engineer, Core Migrations
$230K - $260K *
Lead the charge in client migrations, owning the entire technical lifecycle from legacy analysis to deployment, ensuring precision and collaboration across teams for optimal outcomes...
Reposted today
$59K - $110K *
Engage with patients and caregivers to enhance their treatment journey through education and support. Collaborate with teams to ensure quality service and compliance while driving innovative solutions...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.