Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

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$140K - $160K *

Advance the design and implementation of a robust knowledge architecture for K-12 assessment systems, integrating AI and learning science to enhance educational outcomes through innovative, data-drive...

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  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$85K - $115K *

Transform creator-driven ideas into high-quality deliverables by managing influencer campaigns, coordinating production workflows, and ensuring compliance across multiple platforms. Collaborate with c...

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  •   5 - 7 years exp.  •   Media

$103K - $181K *

Join us to lead high-impact programs and projects, driving strategic initiatives and enhancing performance through data analysis and cross-functional collaboration. Your expertise will guide teams and...

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  •   8 - 10 years exp.  •   Real Estate & Construction

$125K - $185K *

Elevate health outcomes by collaborating on innovative R&D initiatives, supporting program development, and integrating advanced biological systems with cutting-edge technologies in a dynamic, remote...

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  •   5 - 7 years exp.  •   Information Technology

$162K - $211K *

Join a team that's redefining consumer marketing strategies in healthcare. Drive impactful initiatives that enhance patient engagement and awareness while collaborating across functions to shape the f...

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  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Join a team that's dedicated to leading interdisciplinary clinical research projects, ensuring compliance with regulatory standards, and delivering quality results on time and within budget while fost...

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  •   Less than 5 years exp.  •   Healthcare

$104K - $200K *

Advance partner program effectiveness by managing operations, improving processes, and delivering insights. Collaborate with cross-functional teams to enhance the partner ecosystem and drive strategic...

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  •   Less than 5 years exp.  •   Telecommunications & Hardware

$215K - $250K *

Build your career with a pioneering role to shape grantmaking, partner programs, and organizational independence. Lead initiatives, engage stakeholders, and measure success while establishing a founda...

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  •   5 - 7 years exp.  •   Manufacturing & Automotive

$177K - $205K *

Lead the charge in advancing drug substance processes by collaborating with CDMOs and internal teams to ensure timely delivery and adherence to regulatory standards, while providing technical expertis...

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  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate the SWTHZ brand by leading PR, partnerships, and social strategies. Collaborate with creative teams to craft a compelling narrative, engage communities, and drive brand recognition through inn...

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  •   5 - 7 years exp.  •   Hospitality & Recreation

$90K - $105K *

Innovate Salesforce solutions to enhance global operations, translating business needs into effective strategies. Collaborate with teams to optimize user experience and drive revenue growth through ad...

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  •   5 - 7 years exp.  •   Business Services

$200K - $255K *

Elevate your career by driving new business in healthcare accounts. Engage with C-level executives, navigate complex sales cycles, and close high-value deals to expand market presence and achieve reve...

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  •   5 - 7 years exp.  •   Business Services

$86K - $138K *

Empower your career by leading business analysis efforts, collaborating with stakeholders to enhance system applications, and driving innovative solutions that improve operational efficiency and user...

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  •   5 - 7 years exp.  •   Healthcare

$166K - $230K *

Innovate and enhance the machine learning infrastructure to empower rapid model deployment and automation. Collaborate across teams to streamline operations and drive impactful solutions in ML and fin...

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  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Join a dynamic sales team to drive growth in K-12 education, managing the full sales cycle and building strategic partnerships. Shape your territory strategy while enhancing digital learning environme...

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  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$94K - $111K *

Unlock potential by joining our post-acute care team, providing high-quality care in skilled nursing facilities. Collaborate with a multidisciplinary team, enjoy autonomy, and benefit from comprehensi...

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  •   Less than 5 years exp.  •   Finance & Insurance

$166K - $244K *

Lead the Oncology narrative and media strategy, driving impactful communications across channels. Collaborate with cross-functional teams to enhance brand presence and storytelling, ensuring alignment...

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  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate the effectiveness of product vulnerability management by owning processes, driving automation, and collaborating closely with engineering. Be the key point of accountability for reducing risk...

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  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Join a team that's dedicated to solving complex software challenges. As a Sr. Software Engineer, you'll design, build, and maintain robust applications while collaborating across teams to enhance our...

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  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Join a team that's redefining the future by leveraging cutting-edge AI to develop innovative machine learning solutions that solve complex business challenges, and actively collaborating across multid...

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  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Engage with cross-functional teams to shape and deliver innovative classroom experiences. Take ownership of user-facing features and backend services, ensuring alignment with market needs and enhancin...

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  •   5 - 7 years exp.  •   Food & Beverages

$143K - $194K *

Elevate software development by designing and deploying distributed open-source message broker systems. Collaborate with cross-functional teams to drive architecture and best practices while mentoring...

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  •   Less than 5 years exp.  •   Retail & Consumer Goods

$95K - $115K *

Join us to design and deliver innovative mechanical systems for heavy industrial thermal processes. Collaborate with cross-functional teams, mentor junior engineers, and tackle complex challenges in a...

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  •   5 - 7 years exp.  •   Manufacturing & Automotive

$230K - $260K *

Lead the charge in client migrations, owning the entire technical lifecycle from legacy analysis to deployment, ensuring precision and collaboration across teams for optimal outcomes...

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  •   8 - 10 years exp.  •   Information Technology

$59K - $110K *

Engage with patients and caregivers to enhance their treatment journey through education and support. Collaborate with teams to ensure quality service and compliance while driving innovative solutions...

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  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.