Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$94K - $293K *

Unlock the potential of HR transformation by leading strategic projects that integrate digital solutions and optimize processes. Collaborate with clients to enhance HR functions, driving business perf...

5 days ago

  •   8 - 10 years exp.  •   Business Services

$125K - $150K *

Unlock potential by driving enterprise growth in the TOLA region through strategic sales. Engage with senior healthcare executives to transform patient experiences using AI, while managing complex sal...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$130K - $155K *

Empower your career by leading DevOps initiatives, optimizing cloud infrastructure, and driving Agile practices. Collaborate with cross-functional teams to enhance scalability, security, and cost effi...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$180K - $220K *

Lead the evaluation of outpatient referrals and inpatient admissions for medical necessity, utilizing guidelines and criteria to ensure quality care. Collaborate with providers and mentor UM nurses to...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$92K - $120K *

Advance the compensation function through strategic AI application, enhancing processes and decision-making. Collaborate with stakeholders to modernize systems, ensuring operational excellence and com...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$114K - $148K *

Engineer complex ERP solutions by analyzing business processes, defining architecture, and leading integration efforts. Collaborate with teams to optimize performance and ensure compliance while deliv...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Shape the future of clinical research by leading project teams to achieve milestones, ensuring compliance and operational excellence throughout all phases of study management while fostering collabora...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Lead the charge in material planning and inventory control to optimize flow, minimize costs, and ensure timely delivery. Collaborate with cross-functional teams to enhance efficiency and meet customer...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$186K - $252K *

Transform the Renewables market by leading strategy, client engagement, and business development. Drive growth through team development and collaboration, ensuring alignment with market trends and cli...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Take ownership of financial planning and analysis efforts, driving insights and process improvements to enhance business performance as we support a rapidly growing, innovative dental technology compa...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $95K *

Join a team that's redefining pediatric care through advanced ECMO therapies. Utilize your expertise in a high-volume program, providing critical support to neonates and children while engaging in inn...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$170K - $185K *

Elevate your career by leading a dynamic sales organization across North and Latin America. Drive revenue growth, develop high-performing teams, and implement strategic processes for sustainable succe...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$350K - $389K *

Transform patient care by providing expert psychiatric services in a supportive, outpatient environment. Collaborate with a dedicated team to enhance mental health outcomes while enjoying a flexible s...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $170K *

Unlock potential by leading hands-on security engineering efforts to modernize cybersecurity for a major federal agency. Collaborate with teams to remediate vulnerabilities and enhance cloud infrastru...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Lead the charge in driving business development for Technical Flooring, identifying new opportunities, cultivating strategic partnerships, and enhancing client relationships to achieve growth and prof...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Lead the charge in engineering excellence by managing multidisciplinary design efforts, facilitating project success while maintaining utmost quality and compliance. Drive collaboration among teams to...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$90K - $110K *

Champion the recruitment process by sourcing top technical talent, collaborating with leadership, and executing full-cycle hiring strategies to meet business objectives in a fast-paced startup environ...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Empower a dynamic team of Project Managers to drive successful product implementations, enhance operational efficiency, and achieve key performance metrics while fostering cross-functional collaborati...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $182K *

Lead client implementations and provide ongoing support for Sage HCM solutions. Guide customers through the full implementation lifecycle, ensuring successful outcomes and optimizing their HCM environ...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$80K - $95K *

Pioneer innovative clinical workflows and enhance service performance in specialty care. Collaborate with stakeholders to implement programs, analyze outcomes, and drive improvements, ensuring excelle...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $210K *

Join as a strategic leader in Revenue Operations, driving growth initiatives and optimizing performance for a $750M+ Business Unit. Collaborate with executive teams to enhance revenue strategies, fore...

RemoteRemote

5 days ago

  •   11 - 15 years exp.  •   Finance & Insurance

$100K - $130K *

Grow your career with an opportunity to drive sales and build client relationships across a diverse territory. Leverage your technical expertise to promote innovative solutions and achieve results, en...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$107K - $167K *

Shape the future of health and safety by leading compliance efforts across diverse projects. Collaborate with teams nationwide to ensure safe execution through planning, audits, and site evaluations...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Technical Services

$80K - $95K *

Unlock potential by leading a dynamic support team, resolving complex digital banking issues, and enhancing service delivery. Drive operational excellence while mentoring junior specialists and collab...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$170K - $200K *

Unlock potential by overseeing large-scale data center construction projects, ensuring timely delivery, budget adherence, and quality standards while collaborating with diverse stakeholders across all...

5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.