Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$156K - $239K *

Innovate advanced ArcGIS deployments, collaborating with clients to optimize architecture and integration. Join a dynamic team dedicated to enhancing community impact through cutting-edge web and mobi...

4 days ago

  •   11 - 15 years exp.  •   Information Technology

$79K - $133K *

Drive the design and development of geospatial solutions for utilities, enhancing operations and services across multiple industries, including electric, gas, and telecommunications, while collaborati...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Information Technology

$97K - $162K *

Elevate your career by building innovative backend services that leverage cutting-edge GIS technologies. Collaborate with a passionate team to create impactful solutions for Defense and Intel clients...

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$107K - $182K *

Lead the charge in building strategic partnerships with system integrators to drive revenue growth and ArcGIS adoption. Collaborate across teams to enhance partner engagement and execute go-to-market...

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$224K - $356K *

Transform AI inference by leading the development of advanced GPU-accelerated software, driving feature innovation, and enhancing customer adoption in a collaborative open-source environment...

RemoteRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$120K - $234K *

Lead the charge in optimizing SAP Sales and Distribution processes. Collaborate with cross-functional teams to enhance order-to-cash operations while mentoring junior consultants and driving continuou...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Business Services

$94K - $178K *

Elevate application migration success by leading Agile teams through assessments, planning, and execution. Drive collaboration and ensure seamless delivery while managing complex projects aligned with...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Business Services

$135K - $150K *

Drive new business acquisition and revenue growth by proactively selling innovative FinTech solutions to enterprise clients, while managing complex sales cycles and building strategic relationships wi...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $160K *

Transform enterprise data management by leading MDM strategies and architectures. Collaborate with stakeholders to ensure data quality and governance while integrating solutions across platforms like...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Staffing

$120K - $145K *

Transform customer data integration strategies by leveraging your expertise to guide clients in optimizing data flow into the Fusion platform, ensuring reliability and value across complex environment...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Join a team that's redefining payroll solutions by leading Oracle Cloud HCM implementations. Collaborate with stakeholders to design scalable, best-practice solutions while mentoring teams and ensurin...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Staffing

$95K - $115K *

Drive successful Oracle project implementations by managing cross-functional teams, ensuring timely delivery within budget, and fostering collaboration in an Agile environment. Utilize strong problem...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Staffing

$120K - $145K *

Advance organizational change initiatives by leading Oracle Cloud transformations. Collaborate with stakeholders to ensure successful adoption through strategic planning, training, and communication...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Staffing

$110K - $130K *

Transform the landscape of enterprise SEO and AI visibility strategies, driving impactful growth for major brands. Lead project execution and client collaboration to enhance discoverability in traditi...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $180K *

Lead the development of AI governance solutions, transforming research into market-ready products. Collaborate with cross-functional teams to ensure customer-focused outcomes and drive product success...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$138K - $203K *

Empower the future of scalable email systems by developing and managing high-performance backend services. Collaborate with cross-functional teams to enhance cloud infrastructure and optimize microser...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Transportation

$92K - $138K *

Join a dynamic team as a Communication Manager to enhance media visibility, build strategic relationships, and drive impactful communications in the healthcare sector. Leverage your creativity and exp...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$340K - $370K *

Elevate your career by leading critical clinical programs, ensuring high-quality execution from trial design to regulatory interactions. Collaborate cross-functionally to advance pivotal studies in a...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Elevate regional sales performance by leading a high-impact team, executing strategic launches, and fostering key customer relationships in a dynamic, fast-paced environment. Drive accountability and...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Unlock potential by leading the development of a virtual engagement team to enhance outreach to healthcare professionals, ensuring effective collaboration with field sales and marketing for optimal im...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Lead regional sales initiatives, driving product launch success and team performance. Collaborate cross-functionally to execute strategies, foster customer relationships, and ensure compliance while b...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join us to lead solution direction across multiple SAP engagements, ensuring customer value and platform adoption. Collaborate with teams to shape proposals, drive delivery, and influence product deve...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$128K - $150K *

Transform client relationships into growth opportunities as you drive consultative sales cycles for top firms. Collaborate with cross-functional teams to implement strategies, achieve quota, and expan...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $115K *

Champion client success by managing complex engagements in healthcare solutions. Leverage your expertise to enhance Quality/HEDIS, CMS Stars, and Risk Adjustment outcomes, ensuring effective adoption...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $155K *

Elevate school facility performance as a Maintenance Subject Matter Expert, optimizing operations through assessments, planning, and training. Collaborate with leaders nationwide to enhance maintenanc...

4 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.