Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$75K - $92K *

Join a team that's dedicated to optimizing supply operations in programmatic advertising. You'll manage relationships, monitor performance, and troubleshoot issues, ensuring our supply chain operates...

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Reposted today

  •   Less than 5 years exp.  •   Media

$150K - $210K *

Pioneer strategic partnerships within a growing ecosystem, managing existing relationships while identifying new opportunities. Shape the future of the market through collaboration and innovation, dri...

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Reposted today

  •   Less than 5 years exp.  •   Finance & Insurance

$156K - $239K *

Elevate your career by leading the design and delivery of critical ArcGIS deployments. As a Senior System Engineer, you'll optimize geospatial systems in secure environments, guiding customers on stra...

Today

  •   11 - 15 years exp.  •   Information Technology

$97K - $162K *

Elevate your career by engineering CI/CD platforms that ensure secure, reliable software delivery. Collaborate on modern developer tooling and automation, utilizing cutting-edge technologies to suppor...

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$117K - $156K *

Shape the future of clinical trials by managing the execution and oversight of Class III medical device studies. Collaborate with teams and ensure compliance, quality standards, and operational succes...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Join a dynamic team to drive technical success and adoption across enterprise accounts. Leverage your expertise in project management and technical execution to enhance deployment health and fuel acco...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$180K - $230K *

Empower innovation by leading product strategy for hematologic malignancies. Collaborate across teams to drive market entry, clinical support, and evidence generation for cutting-edge diagnostics in a...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Transform strategic initiatives by leading partnerships that drive growth and innovation. Collaborate across teams to enhance business objectives and foster relationships that unlock new opportunities...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Legal & Accounting

$192K - $356K *

Elevate your career with innovative research that merges machine learning and numerical methods, shaping the future of AI-native algorithms for advanced simulation and solver technologies across vario...

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Reposted today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$66K - $120K *

Contribute to the growth of a dynamic restoration business by leveraging your existing network and relationships. Engage in business development, driving lead generation and building long-term partner...

Reposted today

  •   Less than 5 years exp.  •   Real Estate & Construction

$66K - $120K *

Unlock potential by leveraging your established network in the property restoration industry. Engage in relationship-based business development, generating leads and nurturing long-term partnerships t...

Reposted today

  •   Less than 5 years exp.  •   Real Estate & Construction

$125K - $145K *

Deliver engaging multimedia content by leading video production from concept to final delivery. Collaborate with teams to create compelling stories and manage digital assets, ensuring high-quality vis...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Technical Services

$240K - $270K *

Champion web-driven growth by managing comprehensive strategies to enhance GMV. Collaborate across teams to optimize funnel performance, drive conversion, and build capabilities in paid search, SEO, a...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Consumer Technology

$170K - $240K *

Engage in a high-impact role to design and build consumer-centric web applications. Collaborate across teams to enhance performance, mentor engineers, and drive technical decisions that scale innovati...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Consumer Technology

$256K - $302K *

Lead a dynamic engineering team to enhance fan experiences across platforms. Collaborate closely with product and design to drive innovation, ensuring high-quality delivery while leveraging AI tools t...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Consumer Technology

$90K - $115K *

Lead client relationships and project management, ensuring satisfaction and profitability. Collaborate with teams to drive business development and mentor junior staff while maintaining high-quality s...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$116K - $243K *

Take ownership of SAP S/4HANA initiatives in a classified environment, delivering functional expertise in direct procurement and supporting business users and operations. Drive quality across the prog...

Reposted today

  •   Less than 5 years exp.  •   Business Services

$170K - $200K *

Elevate patient care by joining a collaborative anesthesia team, providing outpatient anesthesia services with high autonomy and flexible scheduling, while enjoying competitive pay and a supportive wo...

Today

  •   Less than 5 years exp.  •   Healthcare

$124K - $213K *

Champion growth by leading strategic account management for key global customers, driving innovative solutions and fostering long-term partnerships while ensuring alignment across teams and regions to...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$113K - $188K *

Contribute to the development of embedded software for nuclear systems. Lead a team ensuring design compliance, execute project plans, and enhance operational efficiency. Drive collaboration across di...

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Reposted today

  •   8 - 10 years exp.  •   Business Services

$80K - $95K *

Drive accurate financial reporting and support accounting operations in a dynamic environment. Collaborate cross-functionally to enhance processes and ensure compliance with US GAAP while managing mon...

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Reposted today

  •   Less than 5 years exp.  •   Legal & Accounting

$117K - $165K *

Elevate your career by leading content strategy and development for diverse medical communications. Collaborate with teams, manage projects, and guide junior staff while ensuring accuracy and complian...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$94K - $148K *

Empower healthcare access by educating providers on reimbursement processes. As a Field Reimbursement Specialist, you'll tackle complex insurance challenges, ensuring patients receive specialty medica...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Empower growth by leading Oracle Managed Services sales and strategy. Drive new business, build executive relationships, and enhance service offerings while collaborating with cross-functional teams t...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Staffing

$120K - $145K *

Grow your career with a dynamic role leading Oracle Cloud transformation programs. Oversee multiple projects across CX, ERP, and HCM platforms, ensuring alignment with business objectives while managi...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Staffing

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.