Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$96K - $101K *

Empower domestic workers by leading impactful research initiatives that inform advocacy and policy development. Drive strategic research agendas, mentor a dedicated team, and collaborate with diverse...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Partner with us to enhance patient care by providing expert drug therapy and collaborating with healthcare teams. Your role will be pivotal in ensuring safe medication practices and delivering high-qu...

4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $140K *

Shape the future of financial markets as an Operations Risk Analyst, ensuring the stability of trade processes, monitoring risk exposure, and collaborating across teams to enhance operational resilien...

RemoteRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Unlock potential by driving new business growth in mid-market sectors. Own the full sales cycle, from prospecting to closing, while building relationships and shaping strategies for success in a dynam...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$70K - $150K *

Elevate your career by producing engaging social media videos! Collaborate with creative teams to craft viral content, tailored for TikTok, Instagram, and YouTube. Your editing expertise will drive ca...

RemoteRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$119K - $140K *

Join a team that's dedicated to enhancing customer success through strategic relationships, proactive engagement, and tailored solutions. Drive product adoption and ensure satisfaction while collabora...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $230K *

Empower your career by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and enhance patient access while col...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$285K - $335K *

Lead the charge in developing and executing commercial strategies that drive brand growth and enhance decision-making capabilities across a dynamic portfolio, focusing on oncology and market insights...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$157K - $185K *

Unlock potential by driving relationships with Fortune 500 accounts. Leverage strategic prospecting and consultative selling to deliver exceptional security solutions while managing multiple high-valu...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $187K *

Elevate your career by leading strategic client programs, ensuring alignment across teams to optimize client success and value realization while managing risks and reporting on progress to stakeholder...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$97K - $122K *

Shape the future of energy storage by coordinating utility-scale projects from RFP to preconstruction. Collaborate with cross-functional teams to ensure project viability, manage estimates, and stream...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$225K - $260K *

Unlock your potential by driving strategic growth initiatives in a dynamic consulting environment. Collaborate with sales leadership to enhance account engagement, influence solution design, and foste...

Reposted 4 days ago

  •   11 - 15 years exp.  •   Information Technology

$107K - $182K *

Empower growth by managing strategic partner relationships, driving revenue, and executing go-to-market initiatives. Collaborate across teams to enhance Esri's technology adoption and market presence...

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $197K *

Transform geospatial solutions by architecting and integrating enterprise ArcGIS systems for Defense and Intelligence operations, ensuring secure, scalable architectures that enhance decision-making a...

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$124K - $187K *

Shape your career by leading the design and operation of AI and ML systems. Collaborate across teams to establish architecture standards, optimize workflows, and ensure operational readiness for innov...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Information Technology

$114K - $218K *

Drive success by leveraging your expertise in geospatial technology to enhance customer relationships and optimize solutions in the construction industry. Collaborate with teams to identify growth opp...

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$84K - $142K *

Join a team that's dedicated to transforming utility operations through innovative GIS solutions. Collaborate with clients to enhance their geospatial capabilities, improve data accessibility, and dri...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$112K - $145K *

Drive GTM Analytics within Revenue Strategy, shaping performance metrics, data governance, and analytical support for strategic decisions. Collaborate with cross-functional teams to enhance channel ec...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Transform customer acquisition strategies by launching and optimizing paid campaigns across multiple channels. Collaborate with creative teams and leverage AI tools to enhance performance and drive re...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$150K - $200K *

Create and evolve a distinctive visual identity that resonates across all platforms. Collaborate with teams to translate complex ideas into compelling designs, ensuring a cohesive brand experience tha...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$84K - $142K *

Join a team that's paving the way in GIS systems engineering, focusing on deploying and supporting ArcGIS Enterprise solutions for enterprise-scale challenges. Collaborate with clients to enhance syst...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$114K - $218K *

Join our AEC team to enhance customer relationships and drive growth through innovative geospatial solutions. Collaborate with stakeholders, optimize technology adoption, and deliver impactful strateg...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $210K *

Join a dynamic team to shape financial systems that drive growth and innovation. You'll own the strategy for money movement and banking, collaborating across departments to enhance reliability and sca...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Unlock potential by building and scaling a bare metal cloud infrastructure. Collaborate with a skilled team to automate server lifecycles and design efficient systems, shaping the future of our coloca...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$220K - $290K *

Elevate the user experience in healthcare by leading design innovation! You'll spearhead our design strategy, fostering a high-performance team while simplifying complex workflows into intuitive, beau...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.