Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
$135K - $160K *
Transform your career by leading global product development initiatives, enhancing quality and compliance while driving innovation and operational efficiency across cross-functional teams...
5 days ago
$90K - $147K *
Transform pediatric care by specializing in weight management and collaborating with endocrinologists. Engage in teaching while providing comprehensive medical support to young patients in a dynamic...
5 days ago
$101K - $126K *
Join our team as a Lead System Administrator, overseeing global IT systems infrastructure. You'll ensure data integrity, manage a diverse team, and implement compliance frameworks while driving operat...
5 days ago
Senior Platform Engineer (Infrastructure)
$120K - $145K *
Partner with us to optimize and scale our Ruby on Rails applications, ensuring high availability and performance. Leverage your expertise in cloud infrastructure and Site Reliability Engineering to dr...
5 days ago
$205K - $240K *
Shape the future of oncology as a Senior Medical Science Liaison, creating impactful scientific engagement within hematology and oncology that enhances patient care. Collaborate with KOLs and cross-fu...
Reposted 5 days ago
Manager, Commercial Analytics & Operations
$110K - $130K *
Accelerate your career by driving analytics and operational excellence in a dynamic commercial environment. This role empowers you to enhance reporting, support strategic decisions, and collaborate cr...
5 days ago
Senior Electrical Engineer, Installation
$116K - $170K *
Champion electrical engineering excellence by leading installation standards, ensuring compliance, and driving continuous improvement in warehouse systems. Collaborate with cross-functional teams to e...
5 days ago
Senior Machine Learning (ML) Engineer (CCC Casualty / Claims Intelligence)
$180K - $225K *
Join a team that's redefining AI in auto claims by building and evaluating machine learning models. You'll drive product decisions through data insights, collaborating with experts to enhance claims p...
5 days ago
$95K - $115K *
Join a team that's driving off-page SEO and digital PR to elevate brand authority. You'll manage link building, engage with developer communities, and ensure our solutions are cited by AI platforms, a...
5 days ago
$294K - $367K *
Lead the charge in shaping global tax strategy, ensuring compliance and governance while driving international expansion and sustainable growth. Collaborate with senior leadership to translate complex...
5 days ago
Product Engineer II - Web Services
$79K - $133K *
Elevate progress at the forefront of ArcGIS Hub by transforming customer workflows, communicating priorities, and enhancing geospatial collaboration through innovative product management...
Reposted 5 days ago
Supply Operations Associate, Programmatic
$75K - $92K *
Join a team that's dedicated to optimizing supply operations in programmatic advertising. You'll manage relationships, monitor performance, and troubleshoot issues, ensuring our supply chain operates...
Reposted 5 days ago
Strategic Partnerships Manager
$150K - $210K *
Pioneer strategic partnerships within a growing ecosystem, managing existing relationships while identifying new opportunities. Shape the future of the market through collaboration and innovation, dri...
Reposted 5 days ago
Senior System Engineer - ArcGIS (Mission-Focused)
$156K - $239K *
Elevate your career by leading the design and delivery of critical ArcGIS deployments. As a Senior System Engineer, you'll optimize geospatial systems in secure environments, guiding customers on stra...
5 days ago
DevOps / Platform Engineer - TS/SCI
$97K - $162K *
Elevate your career by engineering CI/CD platforms that ensure secure, reliable software delivery. Collaborate on modern developer tooling and automation, utilizing cutting-edge technologies to suppor...
Reposted 5 days ago
Clinical Trial Manager, Class III Medical Devices
$117K - $156K *
Shape the future of clinical trials by managing the execution and oversight of Class III medical device studies. Collaborate with teams and ensure compliance, quality standards, and operational succes...
Reposted 5 days ago
$120K - $145K *
Join a dynamic team to drive technical success and adoption across enterprise accounts. Leverage your expertise in project management and technical execution to enhance deployment health and fuel acco...
Reposted 5 days ago
Associate Director / Director of Product Management, Signatera Hematologic Oncology (Heme)
$180K - $230K *
Empower innovation by leading product strategy for hematologic malignancies. Collaborate across teams to drive market entry, clinical support, and evidence generation for cutting-edge diagnostics in a...
5 days ago
Director of Strategic Partnerships
$125K - $150K *
Transform strategic initiatives by leading partnerships that drive growth and innovation. Collaborate across teams to enhance business objectives and foster relationships that unlock new opportunities...
5 days ago
Senior Applied Research Scientist - AI Native Numerical Methods
$192K - $356K *
Elevate your career with innovative research that merges machine learning and numerical methods, shaping the future of AI-native algorithms for advanced simulation and solver technologies across vario...
Reposted 5 days ago
Business Development Representative Restoration Industry
$66K - $120K *
Contribute to the growth of a dynamic restoration business by leveraging your existing network and relationships. Engage in business development, driving lead generation and building long-term partner...
Reposted 5 days ago
Business Development Representative Restoration Industry
$66K - $120K *
Unlock potential by leveraging your established network in the property restoration industry. Engage in relationship-based business development, generating leads and nurturing long-term partnerships t...
Reposted 5 days ago
Account Supervisor, Market Access
$90K - $115K *
Lead client relationships and project management, ensuring satisfaction and profitability. Collaborate with teams to drive business development and mentor junior staff while maintaining high-quality s...
5 days ago
SAP Warehouse Management Manager - Onsite in St. Louis, Philadelphia, Arlington, or Huntington Beach
$116K - $243K *
Take ownership of SAP S/4HANA initiatives in a classified environment, delivering functional expertise in direct procurement and supporting business users and operations. Drive quality across the prog...
Reposted 5 days ago
$170K - $200K *
Elevate patient care by joining a collaborative anesthesia team, providing outpatient anesthesia services with high autonomy and flexible scheduling, while enjoying competitive pay and a supportive wo...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.