Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$135K - $160K *

Transform your career by leading global product development initiatives, enhancing quality and compliance while driving innovation and operational efficiency across cross-functional teams...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $147K *

Transform pediatric care by specializing in weight management and collaborating with endocrinologists. Engage in teaching while providing comprehensive medical support to young patients in a dynamic...

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$101K - $126K *

Join our team as a Lead System Administrator, overseeing global IT systems infrastructure. You'll ensure data integrity, manage a diverse team, and implement compliance frameworks while driving operat...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Partner with us to optimize and scale our Ruby on Rails applications, ensuring high availability and performance. Leverage your expertise in cloud infrastructure and Site Reliability Engineering to dr...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$205K - $240K *

Shape the future of oncology as a Senior Medical Science Liaison, creating impactful scientific engagement within hematology and oncology that enhances patient care. Collaborate with KOLs and cross-fu...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Accelerate your career by driving analytics and operational excellence in a dynamic commercial environment. This role empowers you to enhance reporting, support strategic decisions, and collaborate cr...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$116K - $170K *

Champion electrical engineering excellence by leading installation standards, ensuring compliance, and driving continuous improvement in warehouse systems. Collaborate with cross-functional teams to e...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$180K - $225K *

Join a team that's redefining AI in auto claims by building and evaluating machine learning models. You'll drive product decisions through data insights, collaborating with experts to enhance claims p...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Business Services

$95K - $115K *

Join a team that's driving off-page SEO and digital PR to elevate brand authority. You'll manage link building, engage with developer communities, and ensure our solutions are cited by AI platforms, a...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Transportation

$294K - $367K *

Lead the charge in shaping global tax strategy, ensuring compliance and governance while driving international expansion and sustainable growth. Collaborate with senior leadership to translate complex...

United StatesRemote

5 days ago

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$79K - $133K *

Elevate progress at the forefront of ArcGIS Hub by transforming customer workflows, communicating priorities, and enhancing geospatial collaboration through innovative product management...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$75K - $92K *

Join a team that's dedicated to optimizing supply operations in programmatic advertising. You'll manage relationships, monitor performance, and troubleshoot issues, ensuring our supply chain operates...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Media

$150K - $210K *

Pioneer strategic partnerships within a growing ecosystem, managing existing relationships while identifying new opportunities. Shape the future of the market through collaboration and innovation, dri...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$156K - $239K *

Elevate your career by leading the design and delivery of critical ArcGIS deployments. As a Senior System Engineer, you'll optimize geospatial systems in secure environments, guiding customers on stra...

5 days ago

  •   11 - 15 years exp.  •   Information Technology

$97K - $162K *

Elevate your career by engineering CI/CD platforms that ensure secure, reliable software delivery. Collaborate on modern developer tooling and automation, utilizing cutting-edge technologies to suppor...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$117K - $156K *

Shape the future of clinical trials by managing the execution and oversight of Class III medical device studies. Collaborate with teams and ensure compliance, quality standards, and operational succes...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Join a dynamic team to drive technical success and adoption across enterprise accounts. Leverage your expertise in project management and technical execution to enhance deployment health and fuel acco...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$180K - $230K *

Empower innovation by leading product strategy for hematologic malignancies. Collaborate across teams to drive market entry, clinical support, and evidence generation for cutting-edge diagnostics in a...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Transform strategic initiatives by leading partnerships that drive growth and innovation. Collaborate across teams to enhance business objectives and foster relationships that unlock new opportunities...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$192K - $356K *

Elevate your career with innovative research that merges machine learning and numerical methods, shaping the future of AI-native algorithms for advanced simulation and solver technologies across vario...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$66K - $120K *

Contribute to the growth of a dynamic restoration business by leveraging your existing network and relationships. Engage in business development, driving lead generation and building long-term partner...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$66K - $120K *

Unlock potential by leveraging your established network in the property restoration industry. Engage in relationship-based business development, generating leads and nurturing long-term partnerships t...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$90K - $115K *

Lead client relationships and project management, ensuring satisfaction and profitability. Collaborate with teams to drive business development and mentor junior staff while maintaining high-quality s...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$116K - $243K *

Take ownership of SAP S/4HANA initiatives in a classified environment, delivering functional expertise in direct procurement and supporting business users and operations. Drive quality across the prog...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Business Services

$170K - $200K *

Elevate patient care by joining a collaborative anesthesia team, providing outpatient anesthesia services with high autonomy and flexible scheduling, while enjoying competitive pay and a supportive wo...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.