Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$160K - $190K *

Shape the future of commercial law by leading negotiations and advising on product launches. Collaborate with cross-functional teams to enhance legal processes and support strategic growth initiatives...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $140K *

Lead the charge in driving revenue growth and client retention by managing strategic relationships and optimizing operational strategies for a diverse portfolio of enterprise clients in the transporta...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Transportation

$80K - $95K *

Transform quality assurance processes by leading the development and implementation of a robust Quality Management System (QMS) in an automotive manufacturing environment, ensuring compliance and driv...

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$84K - $142K *

Empower mission-driven customers by designing and optimizing ArcGIS Enterprise environments. Leverage hands-on expertise and enterprise IT knowledge to navigate complex technology landscapes and deliv...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$91K - $148K *

Join a team that's dedicated to enhancing software security and privacy. Leverage your expertise to tackle complex security challenges, collaborate with engineers, and influence product development fo...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$84K - $142K *

Lead the charge in designing and implementing scalable geospatial data platforms that enhance Defense and Intelligence operations, ensuring reliable delivery of critical information through robust dat...

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $197K *

Empower mission-critical geospatial data platforms by designing and optimizing secure database solutions. Collaborate across teams to enhance performance and scalability in complex environments, ensur...

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$89K - $166K *

Help us drive growth as you lead a team focusing on Commercial Claims, enhancing key relationships and achieving sales objectives while managing strategic accounts and fostering talent development wit...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$59K - $132K *

Execute comprehensive testing strategies to ensure quality and compliance across various solutions. Manage testing queues, document results, and collaborate with teams to enhance processes while adher...

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $200K *

Support a dynamic team providing exceptional anesthesia care in a collaborative outpatient GI setting. Enjoy a predictable schedule with no call responsibilities, leveraging your skills in a modern, a...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in establishing Forgen's water sector presence across Texas, driving business development and client relationships in flood control and water infrastructure projects while managing a r...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Unlock potential by leading AI product initiatives that enhance business performance. Collaborate with stakeholders to define and prioritize AI solutions, ensuring alignment with strategy and driving...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Staffing

$110K - $140K *

Transform regional accounts by developing strategic programs and building strong relationships with local decision-makers. Drive growth through effective budgeting, insights, and innovative solutions...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$160K - $200K *

Drive growth by leading a national team focused on physician recruitment and market development. Oversee strategic initiatives, manage performance metrics, and foster cross-functional collaboration to...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Analyze and deliver tailored technical solutions, collaborating with teams to implement AI-driven workflows and support complex data migrations, ensuring high-quality service outcomes and stakeholder...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $215K *

Unlock potential by leading regional sales efforts for a groundbreaking product. Drive performance through strategic execution, team leadership, and customer engagement in a fast-paced, entrepreneuria...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Develop and lead regional strategies to drive product launch success, ensuring alignment with corporate goals. Build a high-performing team, foster customer relationships, and execute data-driven deci...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$61K - $101K *

Engage in comprehensive clinical chart reviews to enhance documentation accuracy and compliance. Collaborate with healthcare teams to ensure appropriate coding and reflect patient severity, while driv...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Business Services

$120K - $160K *

Champion quality excellence by leading and standardizing assurance systems across regional logistics operations, driving continuous improvement and client partnerships while supporting new business la...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$143K - $194K *

Lead the development of scalable customer programs to enhance product testing and insights. Collaborate cross-functionally to integrate customer feedback into decision-making, ensuring a seamless cust...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$134K - $209K *

Elevate your career by designing and optimizing a cutting-edge Research Platform. Collaborate with a dynamic team to tackle complex financial datasets and build resilient systems that drive insights f...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$105K - $142K *

Champion operational excellence by optimizing legal systems and workflows. Collaborate cross-functionally to enhance efficiency and drive innovation within the legal team, ensuring seamless communicat...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Drive new logo acquisition and expansion revenue in key accounts, managing full-cycle sales from opportunity to contract. Collaborate with technical teams to build ROI models and ensure accurate forec...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$175K - $210K *

Lead a dynamic security team to shape strategy, enhance operations, and drive governance. Own security engineering, M&A integration, and resilience initiatives while ensuring compliance and trust acro...

United StatesRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Transportation

$175K - $205K *

Transform the future of client technology by leading architectural strategies and integrations in life insurance and annuity environments, ensuring alignment with enterprise goals and delivering scala...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.