Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $116,335
Principal Systems Studies Engineer
$130K - $161K *
Shape the future of power systems engineering by leading advanced studies, consulting, and technology initiatives. Collaborate with utilities and industry organizations to tackle complex challenges an...
Today
$110K - $120K *
Take ownership of client onboarding by guiding users through configuration, data migration, and training while collaborating across teams to ensure seamless implementation and long-term partnership su...
Reposted today
Senior Software Engineer, Backend (Consumer - Risk)
$186K *
Unlock potential by leading the design and delivery of innovative risk systems, optimizing fraud detection and mitigation processes, and mentoring engineers to enhance operational excellence in a dyna...
Today
Senior Application Advisor (Epic Cadence)
$110K - $130K *
Lead the charge in optimizing our Epic systems as a Senior Application Advisor, guiding a dedicated team in enhancing patient access and delivering exceptional service to clients while fostering colla...
Reposted today
$110K - $130K *
Take ownership of the product lifecycle for a cutting-edge SaaS platform, leading cross-functional teams to define strategy, prioritize features, and ensure successful product launches that align with...
Reposted today
Senior AI Transformation Analyst
$90K - $110K *
Drive AI transformation by mapping current processes and designing future-state models across G&A functions. Collaborate with stakeholders to identify automation opportunities and enhance operational...
Reposted today
Senior Product Pricing Manager
$196K - $245K *
Champion strategic pricing initiatives by leveraging data analytics to enhance customer value and drive growth. Collaborate cross-functionally to execute pricing strategies that align with business ob...
Today
$110K - $130K *
Drive new business growth by leveraging your SaaS sales expertise. Engage with property management companies, manage the full sales cycle, and collaborate cross-functionally to ensure client success i...
Today
Principal Full-Stack Data Scientist - Foundational Models
$200K - $237K *
Join a dynamic team to design and deploy cutting-edge machine learning models that enhance personalization and recommendations, driving impactful solutions across diverse datasets and collaborating wi...
Today
$130K - $150K *
Empower our cybersecurity initiatives by providing strategic leadership and ensuring compliance with DoD standards. Drive enterprise-level security architecture and risk management across multiple Tas...
Today
Application Security Architect - AI Harness
$130K - $155K *
Lead the charge in shaping secure software development practices by architecting an innovative CI/CD-integrated AI code evaluation harness to enhance application security and developer trust while ens...
Reposted today
Director of Revenue Operations
$150K - $180K *
Analyze and optimize global GTM operations, driving strategy and execution across account planning, metrics, and AI-enabled technology to enhance revenue performance and streamline processes for maxim...
Today
$100K - $120K *
Partner with us to enhance digital operational resiliency by implementing strategies for business continuity and disaster recovery. Collaborate across teams to assess risks, design resilient architect...
Reposted today
$350K - $400K *
Optimize enterprise sales growth by leading a high-performing team, refining strategies, and driving revenue. Collaborate across departments to enhance processes and ensure long-term success in a dyna...
Reposted today
Human Resources Senior Manager
$110K - $130K *
Elevate your career by driving HR strategies that align with corporate goals. Collaborate with leaders to enhance organizational effectiveness, support talent management, and foster a high-performance...
Reposted today
Account Manager - Industrial Refrigeration
$90K - $120K *
Join a team that's dedicated to transforming customer relationships into long-term partnerships. As a key player, you'll drive account intelligence and uncover revenue opportunities across diverse ind...
Reposted today
$85K - $100K *
Unlock new revenue streams by cultivating partnerships and driving sales growth through effective channel management and collaboration with internal teams in a dynamic environment...
Today
Government Affairs Manager II, Northwest
$159K - $201K *
Unlock potential by cultivating strong relationships with policymakers to shape legislative outcomes for effective advocacy in the Pacific Northwest. Drive strategic initiatives and ensure proactive r...
Reposted today
Myna Account Executive, Healthcare and Dental
$100K - $120K *
Join a team that's transforming healthcare with AI solutions. Drive full-cycle sales, engage decision-makers, and exceed quotas while improving patient access and operational efficiency in dental and...
Today
$80K - $95K *
Transform your sales career by engaging mid-sized businesses with cutting-edge insights. Drive data-driven decisions and close deals while leveraging innovative tools in a dynamic, supportive environm...
Today
$80K - $95K *
Unlock potential by managing environmental assessments across diverse projects. Collaborate with clients and lead fieldwork while ensuring quality control and effective communication throughout the pr...
Today
Accenture Edge for AWS Tech Practice Leader - Migration and Modernization
$163K - $369K *
Lead the migration and modernization practice for mid-market companies, defining strategy, ensuring quality, and driving revenue growth through innovative AWS solutions. Foster talent and build market...
Reposted today
Managing Consultant - Red Team
$135K - $160K *
Lead the charge in delivering top-tier security consulting services while managing a team of experts. Balance hands-on technical engagements with people management to foster growth and operational exc...
Reposted today
$110K *
Join a dynamic team as you oversee a 3PL distribution warehouse, ensuring safety and efficiency while managing operations, budgets, and staff. Drive excellence in customer service and lead a dedicated...
Reposted today
Sr. Product Marketing Manager, Enterprise
$120K - $145K *
Lead and shape the Enterprise narrative, empowering sales and marketing teams with strategic insights and compelling content. Engage complex stakeholders to drive growth and alignment across all custo...
Reposted today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.