Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Staff Security Engineer - SecOps & Threats
$231K - $265K *
Unlock potential by executing security operations, identifying threats, and developing automation to enhance incident response and security posture, while collaborating with cross-functional teams to...
Reposted 5 days ago
$125K - $150K *
Elevate your career by owning the video production process from concept to publish. Lead a team to enhance quality and engagement, targeting security and IT leaders while driving audience growth acros...
5 days ago
$100K - $120K *
Empower your career by transforming business needs into innovative Salesforce solutions. Collaborate with cross-functional teams to deliver enterprise cloud technology, ensuring seamless user experien...
5 days ago
Regional Sales Director - Memphis
$180K - $215K *
Lead the charge in regional sales execution, driving product launch success and team performance through strategic planning, customer engagement, and cross-functional collaboration in a dynamic enviro...
Reposted 5 days ago
Salesforce Developer (Software Engineering)
$92K - $153K *
Join a dynamic team to architect and develop innovative Salesforce solutions, transforming business needs into scalable applications. Collaborate with stakeholders to enhance enterprise capabilities a...
5 days ago
$80K - $95K *
Elevate brand visibility and engagement by managing PR agency partnerships, developing internal communications strategies, and ensuring consistent messaging across channels to strengthen organizationa...
Reposted 5 days ago
Principal Engineer - FPGA/ASIC Design
$130K - $155K *
Innovate cutting-edge FPGA/ASIC designs while collaborating with a global team. Engage in all project phases, from architecture to testing, tackling complex challenges in engine control systems with a...
5 days ago
Director, Product Management - AI
$216K - $236K *
Join a team that's redefining AI product management by driving ROI through innovative solutions. Lead the development of AI capabilities that enhance Alteryx workflows, ensuring faster, better, and ch...
Reposted 5 days ago
$108K - $130K *
Shape the future of data-driven decision-making by leading a team that delivers complex analysis and reporting. Drive operational insights, enhance resource allocation, and support strategic initiativ...
Reposted 5 days ago
Senior Data Architect (Data Foundation & AI Data Readiness)
$132K - $155K *
Empower enterprises to modernize data ecosystems by architecting scalable solutions that enhance data accessibility and quality, driving measurable business value through collaboration and innovative...
5 days ago
Director of Clinical Reimbursement, Skilled Nursing
$125K - $150K *
Champion the integration of clinical reimbursement expertise into product development, ensuring compliance and accuracy in skilled nursing assessments. Collaborate with teams to enhance client outcome...
5 days ago
$132K - $178K *
Advance your career by leading claims and litigation management. Oversee claims handling, evaluate staff performance, manage reserves, and collaborate cross-functionally to enhance department efficien...
Reposted 5 days ago
Senior Channel Specialist - Paid Search
$80K - $90K *
Grow your career with a robust role in executing paid search campaigns while driving performance in a multi-brand environment. Join a dynamic team committed to optimizing revenue through strategic ad...
Reposted 5 days ago
$80K - $95K *
Support payroll and benefits operations for a remote workforce, ensuring compliance and accuracy in processing. Collaborate with HR and Finance to enhance employee experience and streamline processes...
5 days ago
$98K - $163K *
Shape your career by providing Tier III IT Systems support across enterprise technologies. Collaborate on projects, resolve complex challenges, and mentor junior engineers while ensuring operational e...
5 days ago
$105K - $177K *
Drive the development and implementation of data governance initiatives, enhancing data quality and stewardship across the organization while empowering stakeholders through tailored training and supp...
5 days ago
Associate Estate Strategist- Private Wealth
$80K - $95K *
Unlock potential by joining a dynamic team focused on high net worth estate planning. Collaborate with experts to deliver tailored financial strategies, ensuring clients achieve their estate and legac...
5 days ago
External Affairs Manager (Remote, US)
$90K - $105K *
Engage with key healthcare stakeholders as you track legislative changes and manage relationships. Drive the External Affairs function by organizing priorities and processes, ensuring Propelus stays a...
5 days ago
Federal Enterprise Solution Architect
$128K - $160K *
Empower federal agencies by delivering tailored data governance solutions, ensuring compliance and driving measurable outcomes. Collaborate cross-functionally to enhance customer success and expand Co...
Reposted 5 days ago
Regional Sales Manager, Sports Surgical - Midwest
$134K - $216K *
Lead the charge in driving sales strategies and operations for a premier MedTech portfolio. Oversee a diverse sales team, enhance customer relationships, and achieve growth targets while ensuring comp...
5 days ago
Strategic Account Manager (SAM)
$105K - $120K *
Lead strategic partnerships by driving sales growth and managing complex relationships. Implement tailored sales strategies that adapt to market trends and partner needs, collaborating closely with se...
Reposted 5 days ago
Senior / Lead Site Reliability Engineer
$112K - $154K *
Advance your career as a Senior Site Reliability Engineer, focusing on automation, reliability, and performance. Collaborate with teams to enhance application performance and operational efficiency wh...
5 days ago
$110K - $130K *
Elevate your career as you drive QA best practices and develop automation frameworks with Playwright. Collaborate with teams, enhance software quality, and mentor junior engineers while ensuring effic...
Reposted 5 days ago
Senior Software Engineer, AI Platform
$138K - $165K *
Transform AI capabilities by building robust SDKs and infrastructure. Collaborate with product teams to enhance agent workflows, ensuring reliability and performance while driving innovation in AI exp...
5 days ago
Vice President of Data Engineering - Hospital Systems
$297K - $367K *
Grow your career with a pivotal role driving hospital data integration and compliance. Lead execution of clinical data operations, build relationships, and ensure secure data handling while shaping a...
Reposted 5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.