Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$223K - $313K *

Join a distinguished team of physicians to enhance inpatient care quality through expert clinical reviews and utilization management, impacting patient outcomes while enjoying a structured, collaborat...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Shape user experiences by designing intuitive interfaces for a cutting-edge security platform. Collaborate with engineers to create impactful visual workflows, leveraging modern technologies to enhanc...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Business Services

$107K - $143K *

Advance your career by driving strategic GTM solutions, aligning cross-functional teams, and optimizing sales processes to enhance pipeline performance and bookings outcomes in a dynamic environment...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$103K - $295K *

Champion SAP Finance solutions by leading design, configuration, and testing efforts. Collaborate with cross-functional teams to enhance financial processes and mentor junior consultants, ensuring ali...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$103K - $196K *

Lead the charge in optimizing SAP S/4HANA procurement processes within a classified aerospace and defense environment, ensuring effective operations and supporting future program enhancements through...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Business Services

$106K - $206K *

Drive data migration excellence by leading end-to-end SAP S/4HANA initiatives. Collaborate with cross-functional teams to ensure accurate data loads and implement best practices in data governance and...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Business Services

$92K - $224K *

Engage in end-to-end SAP WMS solutions, drive client workshops, configure systems, and lead teams to enhance warehouse operations seamlessly while ensuring integration and mentoring junior consultants...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Champion data excellence by designing and optimizing scalable data platforms. Collaborate with cross-functional teams to enhance performance and drive innovation in data processing, ensuring alignment...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Drive product ownership and functional support for Oracle Fusion SCM and Fleet Management. Collaborate with stakeholders to resolve complex issues, enhance processes, and shape the product roadmap whi...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Staffing

$110K - $130K *

Drive project success by implementing Oracle Primavera P6 solutions, optimizing project controls, and integrating with Oracle Cloud applications to enhance scheduling, resource management, and financi...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Staffing

$110K - $130K *

Lead the charge in Oracle Cloud HCM consulting, guiding clients through implementations while leveraging your expertise in multiple modules. Collaborate on diverse projects, providing mentorship and d...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Staffing

$150K - $180K *

Lead the charge in transforming Oracle HCM practices by driving strategic growth, fostering innovation, and building high-performing teams. Collaborate with clients and partners to deliver exceptional...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Staffing

$246K - $273K *

Build and lead a high-impact marketing organization to drive customer growth, product launches, and performance metrics in a dynamic, Bitcoin-focused environment. Collaborate cross-functionally and ta...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$92K - $105K *

Join a team that's driving innovative SEM strategies for transformative clients. Lead paid search campaigns, mentor a dynamic team, and utilize data-driven insights to optimize performance and achieve...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Accelerate your career by driving brand awareness and demand generation through innovative marketing strategies in a dynamic consulting environment. Collaborate with cross-functional teams to enhance...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Staffing

$95K - $115K *

Serve as a strategic advisor to clients, leading performance marketing initiatives and fostering growth through integrated strategies, analytics, and emerging technologies while mentoring team members...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Lead the charge in enhancing patient starts and scan volume through strategic partnerships and targeted marketing initiatives, ensuring territory growth and revenue commitments are met while cultivati...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$215K - $240K *

Shape the future of drug development by leading analytical strategies, ensuring compliance and optimization of processes across lifecycle stages, and collaborating with cross-functional teams and exte...

United StatesRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$134K - $145K *

Optimize commercial accounting processes by managing revenue, inventory, and accounts receivable. Collaborate with cross-functional teams to ensure accurate financial reporting and drive process impro...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$68K - $120K *

Lead the charge in managing oncology clinical trials, ensuring efficient operations, compliance, and stakeholder engagement throughout the trial lifecycle while collaborating with various teams and ma...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$134K - $162K *

Champion the adoption of innovative cardiovascular therapies by engaging healthcare providers through scientific dialogue and tailored customer experiences, driving demand and ensuring optimal patient...

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$88K - $105K *

Lead strategic pitch support initiatives, enhancing presentation effectiveness and driving customer engagement through storytelling and collaboration across teams. Manage multiple projects while ensur...

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $150K *

Empower early talent recruitment by leading a dynamic screener team. Drive application reviews, maintain selection standards, and ensure timely candidate decisions while collaborating closely with lea...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$157K - $212K *

Join a team that's dedicated to leading complex projects and programs. You'll analyze risks, develop integrated plans, and foster relationships with stakeholders to ensure successful execution and com...

5 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$198K - $269K *

Shape the future of aerospace by leading a dynamic team in sustaining F/A-18 operations. Drive engineering excellence, ensure safety, and collaborate with cross-functional teams to deliver top-tier su...

5 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.