Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$200K - $230K *

Transform laboratory automation by leading the integration of intelligent workflows, AI, and interoperability standards to create scalable, innovative solutions that enhance scientific capabilities ac...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Unlock your potential by supporting complex customer needs through expert solution design and seamless sales transitions. Collaborate with teams to drive sales opportunities and enhance customer engag...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$148K - $175K *

Unlock potential by leading quantitative testing and monitoring for AI models in compliance, ensuring data quality and regulatory adherence while collaborating across teams to enhance financial crime...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$193K - $228K *

Lead the charge in transforming enterprise architecture by aligning technology with business goals, driving innovation, and managing technical debt to enhance application ecosystems and ensure scalabi...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$200K - $383K *

Join a team that's redefining internal audit excellence. Lead strategic initiatives, enhance risk management, and drive compliance while leveraging cutting-edge technologies to optimize processes and...

United StatesRemote

5 days ago

  •   15+ years exp.  •   Real Estate & Construction

$177K - $290K *

Transform UX operations by unifying decision-making and enhancing workflows across disciplines. Drive continuous improvement through automation and strategic partnerships, ensuring a cohesive UX organ...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$140K - $160K *

Advance the design and implementation of a robust knowledge architecture for K-12 assessment systems, integrating AI and learning science to enhance educational outcomes through innovative, data-drive...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$85K - $115K *

Transform creator-driven ideas into high-quality deliverables by managing influencer campaigns, coordinating production workflows, and ensuring compliance across multiple platforms. Collaborate with c...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Media

$125K - $185K *

Elevate health outcomes by collaborating on innovative R&D initiatives, supporting program development, and integrating advanced biological systems with cutting-edge technologies in a dynamic, remote...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$162K - $211K *

Join a team that's redefining consumer marketing strategies in healthcare. Drive impactful initiatives that enhance patient engagement and awareness while collaborating across functions to shape the f...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Join a team that's dedicated to leading interdisciplinary clinical research projects, ensuring compliance with regulatory standards, and delivering quality results on time and within budget while fost...

RemoteRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$177K - $205K *

Lead the charge in advancing drug substance processes by collaborating with CDMOs and internal teams to ensure timely delivery and adherence to regulatory standards, while providing technical expertis...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate the SWTHZ brand by leading PR, partnerships, and social strategies. Collaborate with creative teams to craft a compelling narrative, engage communities, and drive brand recognition through inn...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$200K - $255K *

Elevate your career by driving new business in healthcare accounts. Engage with C-level executives, navigate complex sales cycles, and close high-value deals to expand market presence and achieve reve...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Business Services

$166K - $230K *

Innovate and enhance the machine learning infrastructure to empower rapid model deployment and automation. Collaborate across teams to streamline operations and drive impactful solutions in ML and fin...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Join a dynamic sales team to drive growth in K-12 education, managing the full sales cycle and building strategic partnerships. Shape your territory strategy while enhancing digital learning environme...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$94K - $111K *

Unlock potential by joining our post-acute care team, providing high-quality care in skilled nursing facilities. Collaborate with a multidisciplinary team, enjoy autonomy, and benefit from comprehensi...

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Join us to design and deliver innovative mechanical systems for heavy industrial thermal processes. Collaborate with cross-functional teams, mentor junior engineers, and tackle complex challenges in a...

5 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$230K - $260K *

Lead the charge in client migrations, owning the entire technical lifecycle from legacy analysis to deployment, ensuring precision and collaboration across teams for optimal outcomes...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$59K - $110K *

Engage with patients and caregivers to enhance their treatment journey through education and support. Collaborate with teams to ensure quality service and compliance while driving innovative solutions...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Business Services

$58K - $108K *

Join a team that's dedicated to enhancing patient experiences through compassionate support and education in Hepatology. Engage with patients and caregivers, providing vital resources and guidance thr...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Business Services

$105K - $135K *

Lead financial planning and analysis efforts, partnering with business leaders to drive strategic insights, enhance decision-making, and improve operational excellence through data-driven financial mo...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$96K - $115K *

Lead the charge in designing and developing aerospace wire harnesses, ensuring compliance with industry standards while collaborating with multidisciplinary teams to deliver innovative solutions...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$114K - $218K *

Transform the construction industry by leveraging geospatial technology to enhance customer relationships and optimize strategies for growth. Collaborate with experts and use your industry insights to...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Information Technology

$97K - $162K *

Innovate backend solutions for critical national security missions, developing APIs and data capabilities in cloud environments. Collaborate with Defense and Intelligence sectors to solve complex tech...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.