Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Director, Intelligent Instruments & Automation
$200K - $230K *
Transform laboratory automation by leading the integration of intelligent workflows, AI, and interoperability standards to create scalable, innovative solutions that enhance scientific capabilities ac...
5 days ago
$110K - $130K *
Unlock your potential by supporting complex customer needs through expert solution design and seamless sales transitions. Collaborate with teams to drive sales opportunities and enhance customer engag...
5 days ago
Senior Associate, Compliance Model Governance
$148K - $175K *
Unlock potential by leading quantitative testing and monitoring for AI models in compliance, ensuring data quality and regulatory adherence while collaborating across teams to enhance financial crime...
5 days ago
$193K - $228K *
Lead the charge in transforming enterprise architecture by aligning technology with business goals, driving innovation, and managing technical debt to enhance application ecosystems and ensure scalabi...
5 days ago
Vice President, Chief Audit Executive (CAE)
$200K - $383K *
Join a team that's redefining internal audit excellence. Lead strategic initiatives, enhance risk management, and drive compliance while leveraging cutting-edge technologies to optimize processes and...
5 days ago
User Experience Operations Lead
$177K - $290K *
Transform UX operations by unifying decision-making and enhancing workflows across disciplines. Drive continuous improvement through automation and strategic partnerships, ensuring a cohesive UX organ...
Reposted 5 days ago
$140K - $160K *
Advance the design and implementation of a robust knowledge architecture for K-12 assessment systems, integrating AI and learning science to enhance educational outcomes through innovative, data-drive...
5 days ago
Senior, Influencer Manager - Creative - US Remote
$85K - $115K *
Transform creator-driven ideas into high-quality deliverables by managing influencer campaigns, coordinating production workflows, and ensuring compliance across multiple platforms. Collaborate with c...
5 days ago
ARPA-H Senior Scientist / Engineer (Regenerative Medicine & Advanced Biological Systems)
$125K - $185K *
Elevate health outcomes by collaborating on innovative R&D initiatives, supporting program development, and integrating advanced biological systems with cutting-edge technologies in a dynamic, remote...
5 days ago
Director, Consumer Marketing & Strategy
$162K - $211K *
Join a team that's redefining consumer marketing strategies in healthcare. Drive impactful initiatives that enhance patient engagement and awareness while collaborating across functions to shape the f...
5 days ago
Early Phase Clinical Project Manager
$110K - $130K *
Join a team that's dedicated to leading interdisciplinary clinical research projects, ensuring compliance with regulatory standards, and delivering quality results on time and within budget while fost...
5 days ago
Associate Director/Director Process Chemistry
$177K - $205K *
Lead the charge in advancing drug substance processes by collaborating with CDMOs and internal teams to ensure timely delivery and adherence to regulatory standards, while providing technical expertis...
5 days ago
Director, Brand Marketing - SWTHZ
$110K - $130K *
Elevate the SWTHZ brand by leading PR, partnerships, and social strategies. Collaborate with creative teams to craft a compelling narrative, engage communities, and drive brand recognition through inn...
5 days ago
Account Executive - Healthcare
$200K - $255K *
Elevate your career by driving new business in healthcare accounts. Engage with C-level executives, navigate complex sales cycles, and close high-value deals to expand market presence and achieve reve...
Reposted 5 days ago
Senior Software Engineer - Machine Learning Platform
$166K - $230K *
Innovate and enhance the machine learning infrastructure to empower rapid model deployment and automation. Collaborate across teams to streamline operations and drive impactful solutions in ML and fin...
Reposted 5 days ago
Account Executive - Midwest / Central
$80K - $95K *
Join a dynamic sales team to drive growth in K-12 education, managing the full sales cycle and building strategic partnerships. Shape your territory strategy while enhancing digital learning environme...
5 days ago
$94K - $111K *
Unlock potential by joining our post-acute care team, providing high-quality care in skilled nursing facilities. Collaborate with a multidisciplinary team, enjoy autonomy, and benefit from comprehensi...
5 days ago
$95K - $115K *
Join us to design and deliver innovative mechanical systems for heavy industrial thermal processes. Collaborate with cross-functional teams, mentor junior engineers, and tackle complex challenges in a...
5 days ago
Staff Data Engineer, Core Migrations
$230K - $260K *
Lead the charge in client migrations, owning the entire technical lifecycle from legacy analysis to deployment, ensuring precision and collaboration across teams for optimal outcomes...
Reposted 5 days ago
$59K - $110K *
Engage with patients and caregivers to enhance their treatment journey through education and support. Collaborate with teams to ensure quality service and compliance while driving innovative solutions...
5 days ago
Bilingual Virtual Clinical Educator
$58K - $108K *
Join a team that's dedicated to enhancing patient experiences through compassionate support and education in Hepatology. Engage with patients and caregivers, providing vital resources and guidance thr...
5 days ago
$105K - $135K *
Lead financial planning and analysis efforts, partnering with business leaders to drive strategic insights, enhance decision-making, and improve operational excellence through data-driven financial mo...
5 days ago
$96K - $115K *
Lead the charge in designing and developing aerospace wire harnesses, ensuring compliance with industry standards while collaborating with multidisciplinary teams to deliver innovative solutions...
Reposted 5 days ago
Sr. Account Manager - Construction
$114K - $218K *
Transform the construction industry by leveraging geospatial technology to enhance customer relationships and optimize strategies for growth. Collaborate with experts and use your industry insights to...
Reposted 5 days ago
Backend Software Engineer - TS/SCI
$97K - $162K *
Innovate backend solutions for critical national security missions, developing APIs and data capabilities in cloud environments. Collaborate with Defense and Intelligence sectors to solve complex tech...
Reposted 5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.