Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Vice President, Deputy General Counsel, Product, Regulatory & Litigation
$370K - $415K *
Unlock potential by leading Affirm's global legal strategy across Product, Regulatory, and Litigation teams. Collaborate with executives to drive innovation while managing complex legal risks in the c...
4 days ago
$83K - $140K *
Innovate financial strategies by partnering with R&D leaders to optimize costs, enhance reporting frameworks, and drive accurate forecasting in a dynamic environment. Your analytical skills will shape...
4 days ago
Senior Medical Science Liaison - Bone Health - MO, AR, KS
$172K - $233K *
Engage with healthcare leaders to advance scientific communication in bone health. This role involves collaboration, mentorship, and strategic support to enhance patient care and drive research initia...
4 days ago
$95K - $115K *
Shape the future of our organic social media presence by managing channels, coordinating campaigns, and leveraging analytics to enhance engagement and community growth across multiple platforms...
4 days ago
$85K - $118K *
Empower patient care by delivering dialysis treatments and collaborating with a dedicated team. Utilize your critical thinking skills in a fast-paced environment to ensure the safety and wellbeing of...
4 days ago
Altium Designer Trainer and Content Creator
$118K - $141K *
Deliver engaging training and develop content for Altium Designer, leveraging your PCB design expertise. Collaborate with teams to enhance training quality and support customer adoption through effect...
4 days ago
Senior Software Engineer, Operations Tools & Al Enablement
$120K - $145K *
Join a dynamic team to enhance Robotics Operations through innovative software solutions. Collaborate with cross-functional teams to identify needs, deliver impactful improvements, and maintain reliab...
4 days ago
$125K - $145K *
Lead and optimize transportation operations, driving excellence through team development, P&L management, and strategic partnerships. Foster a safety-first culture while exceeding customer expectation...
4 days ago
Commercial Project Manager, Pharmaceuticals
$80K - $95K *
Shape customer success by managing project timelines and expectations, fostering relationships, and ensuring accurate forecasting and billing. Drive operational excellence and continuous improvement t...
Reposted 4 days ago
$110K - $130K *
Champion employment law compliance and support HR initiatives in a dynamic startup. Collaborate with management and People Operations to address legal matters, streamline processes, and ensure best pr...
4 days ago
$74K - $93K *
Join a dedicated team as a Residential Nurse, providing compassionate care and support to residents in a transitional program. Collaborate with interdisciplinary teams to foster a safe and nurturing e...
4 days ago
$80K - $100K *
Engage customers by providing exceptional service and guidance in vehicle selection. Drive sales growth through relationship building and product knowledge while ensuring a positive dealership experie...
4 days ago
$65K - $181K *
Drive success by providing high-level executive support in a dynamic environment. Collaborate with cross-functional teams, manage complex schedules, and enhance organizational efficiency while maintai...
4 days ago
Director, Merchandising Operations
$145K - $180K *
Champion operational excellence by leading a dynamic team to enhance processes, drive complex projects, and ensure seamless collaboration across departments, all while improving patient outcomes in th...
4 days ago
Senior Proposal Strategist - Water (Kansas City, MO)
$95K - $115K *
Explore your career potential by leading proposal strategies that enhance competitive positioning. Collaborate with teams to develop compelling narratives and visuals, ensuring successful project subm...
4 days ago
Partnerships Operations Manager
$92K - $128K *
Transform partnership operations by managing billing, benefit administration, and cross-functional projects. Leverage your organizational skills to enhance member experiences and streamline processes...
4 days ago
$120K - $145K *
Join a team that's dedicated to enhancing client operations and driving revenue cycle success. Lead initiatives, foster relationships, and ensure performance excellence while collaborating with stakeh...
4 days ago
$250K - $289K *
Transform AI/ML engineering by leading innovative platform design and implementation, ensuring reliability and scalability to meet growing needs while collaborating across teams to drive business impa...
Reposted 4 days ago
Lead Consultant - Cybersecurity Commissioning, Verification & Validation
$110K - $130K *
Shape the future of cybersecurity by leading verification and validation efforts across industrial environments. Drive technical assessments, develop procedures, and ensure compliance with cybersecuri...
4 days ago
$110K - $130K *
Join us to take technical ownership of our global WordPress platform, enhancing performance and scalability. Collaborate with cross-functional teams to develop custom solutions and ensure a seamless u...
Reposted 4 days ago
$69K - $94K *
Manage procurement activities to ensure timely, cost-effective sourcing of goods and services. Collaborate with suppliers, optimize supply chain execution, and support contract negotiations to meet cu...
4 days ago
$85K - $100K *
Transform workplace safety and compliance by leading EHS initiatives, ensuring adherence to regulations, and fostering a culture of health and safety within the manufacturing environment...
4 days ago
Senior Software Engineer - Front End/Back End (Library of Congress)
$120K - $150K *
Unlock potential by leading software engineering initiatives, mentoring junior engineers, and driving improvements in development processes. Collaborate with stakeholders to deliver impactful solution...
Reposted 4 days ago
$80K - $95K *
Advance workplace safety and compliance by leading EHS initiatives, managing regulations, and fostering a culture of health and safety. Collaborate with teams to ensure a secure environment while driv...
4 days ago
Senior / Staff Product Manager - IoT Connected Devices
$180K - $248K *
Shape the future of connected devices as the product leader for in-field asset monitoring. Own the hardware roadmap, drive product introductions, and ensure reliability, directly influencing a key gro...
Reposted 4 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.