Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Forward Deployed Consultant, Manufacturing
$125K - $150K *
Drive AI transformations in manufacturing by collaborating with C-level executives to identify high-impact opportunities, build tailored solutions, and achieve measurable results in core operating pro...
Reposted 4 days ago
Senior Risk Manager - Investment Advisory
$110K - $130K *
Join a team that's dedicated to managing investment advisory risks, collaborating across the organization to enhance risk management initiatives and support the Enterprise Risk Management framework. D...
Reposted 4 days ago
Manager, Bulk Distribution Services
$95K - $165K *
Lead the charge in optimizing bulk distribution services, managing barge supply chains, and ensuring operational excellence from stockpile management to delivery. Collaborate cross-functionally to enh...
Reposted 4 days ago
$125K - $150K *
Empower customer success by designing impactful journeys that drive retention and revenue. Lead cross-functional teams to create and optimize service blueprints, ensuring seamless customer experiences...
4 days ago
Taxpayer Advocate Group Manager
$80K - $95K *
Transform taxpayer advocacy by leading a dedicated team to resolve complex cases, ensuring timely solutions and alignment with national priorities while fostering collaboration across IRS divisions...
4 days ago
Staff Data Scientist - Ads Marketplace
$190K - $283K *
Drive impactful data analyses and innovative experiment design to enhance product strategies and optimize Ads Marketplace performance, collaborating with cross-functional teams in a flexible, hybrid w...
Reposted 4 days ago
Finance Manager, Adaptive Planning
$110K - $130K *
Lead the charge in optimizing our Adaptive Planning platform, ensuring accurate data management and seamless integrations. Collaborate with cross-functional teams to enhance reporting and streamline f...
4 days ago
Senior Account Manager, Paid Media (Omnichannel)
$75K - $95K *
Elevate mobile app acquisition strategies by managing omni-channel paid media campaigns. Collaborate with clients to optimize performance, drive growth, and ensure seamless execution across platforms...
4 days ago
$90K - $92K *
Join a dynamic team as you support project execution and management for USACE maintenance tasks. Collaborate with stakeholders, track performance metrics, and guide project teams to ensure successful...
4 days ago
Vice President, Deputy General Counsel, Product, Regulatory & Litigation
$370K - $415K *
Unlock potential by leading Affirm's global legal strategy across Product, Regulatory, and Litigation teams. Collaborate with executives to drive innovation while managing complex legal risks in the c...
4 days ago
$83K - $140K *
Innovate financial strategies by partnering with R&D leaders to optimize costs, enhance reporting frameworks, and drive accurate forecasting in a dynamic environment. Your analytical skills will shape...
4 days ago
Senior Medical Science Liaison - Bone Health - MO, AR, KS
$172K - $233K *
Engage with healthcare leaders to advance scientific communication in bone health. This role involves collaboration, mentorship, and strategic support to enhance patient care and drive research initia...
4 days ago
$95K - $115K *
Shape the future of our organic social media presence by managing channels, coordinating campaigns, and leveraging analytics to enhance engagement and community growth across multiple platforms...
4 days ago
$85K - $118K *
Empower patient care by delivering dialysis treatments and collaborating with a dedicated team. Utilize your critical thinking skills in a fast-paced environment to ensure the safety and wellbeing of...
4 days ago
Altium Designer Trainer and Content Creator
$118K - $141K *
Deliver engaging training and develop content for Altium Designer, leveraging your PCB design expertise. Collaborate with teams to enhance training quality and support customer adoption through effect...
4 days ago
Senior Software Engineer, Operations Tools & Al Enablement
$120K - $145K *
Join a dynamic team to enhance Robotics Operations through innovative software solutions. Collaborate with cross-functional teams to identify needs, deliver impactful improvements, and maintain reliab...
4 days ago
$125K - $145K *
Lead and optimize transportation operations, driving excellence through team development, P&L management, and strategic partnerships. Foster a safety-first culture while exceeding customer expectation...
4 days ago
Commercial Project Manager, Pharmaceuticals
$80K - $95K *
Shape customer success by managing project timelines and expectations, fostering relationships, and ensuring accurate forecasting and billing. Drive operational excellence and continuous improvement t...
Reposted 4 days ago
$110K - $130K *
Champion employment law compliance and support HR initiatives in a dynamic startup. Collaborate with management and People Operations to address legal matters, streamline processes, and ensure best pr...
4 days ago
$74K - $93K *
Join a dedicated team as a Residential Nurse, providing compassionate care and support to residents in a transitional program. Collaborate with interdisciplinary teams to foster a safe and nurturing e...
4 days ago
$80K - $100K *
Engage customers by providing exceptional service and guidance in vehicle selection. Drive sales growth through relationship building and product knowledge while ensuring a positive dealership experie...
4 days ago
$65K - $181K *
Drive success by providing high-level executive support in a dynamic environment. Collaborate with cross-functional teams, manage complex schedules, and enhance organizational efficiency while maintai...
4 days ago
Director, Merchandising Operations
$145K - $180K *
Champion operational excellence by leading a dynamic team to enhance processes, drive complex projects, and ensure seamless collaboration across departments, all while improving patient outcomes in th...
4 days ago
Senior Proposal Strategist - Water (Kansas City, MO)
$95K - $115K *
Explore your career potential by leading proposal strategies that enhance competitive positioning. Collaborate with teams to develop compelling narratives and visuals, ensuring successful project subm...
4 days ago
Partnerships Operations Manager
$92K - $128K *
Transform partnership operations by managing billing, benefit administration, and cross-functional projects. Leverage your organizational skills to enhance member experiences and streamline processes...
4 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.