Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$110K - $130K *

Drive project success by implementing Oracle Primavera P6 solutions, optimizing project controls, and integrating with Oracle Cloud applications to enhance scheduling, resource management, and financi...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Staffing

$110K - $130K *

Lead the charge in Oracle Cloud HCM consulting, guiding clients through implementations while leveraging your expertise in multiple modules. Collaborate on diverse projects, providing mentorship and d...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Staffing

$150K - $180K *

Lead the charge in transforming Oracle HCM practices by driving strategic growth, fostering innovation, and building high-performing teams. Collaborate with clients and partners to deliver exceptional...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Staffing

$246K - $273K *

Build and lead a high-impact marketing organization to drive customer growth, product launches, and performance metrics in a dynamic, Bitcoin-focused environment. Collaborate cross-functionally and ta...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $165K *

Join a team that's redefining healthcare technology by owning the product roadmap, translating company goals into actionable tasks, and ensuring seamless delivery of AI-driven solutions that enhance p...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$92K - $105K *

Join a team that's driving innovative SEM strategies for transformative clients. Lead paid search campaigns, mentor a dynamic team, and utilize data-driven insights to optimize performance and achieve...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Accelerate your career by driving brand awareness and demand generation through innovative marketing strategies in a dynamic consulting environment. Collaborate with cross-functional teams to enhance...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Staffing

$95K - $115K *

Serve as a strategic advisor to clients, leading performance marketing initiatives and fostering growth through integrated strategies, analytics, and emerging technologies while mentoring team members...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Lead the charge in enhancing patient starts and scan volume through strategic partnerships and targeted marketing initiatives, ensuring territory growth and revenue commitments are met while cultivati...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$215K - $240K *

Shape the future of drug development by leading analytical strategies, ensuring compliance and optimization of processes across lifecycle stages, and collaborating with cross-functional teams and exte...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$134K - $145K *

Optimize commercial accounting processes by managing revenue, inventory, and accounts receivable. Collaborate with cross-functional teams to ensure accurate financial reporting and drive process impro...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$73K - $101K *

Champion warehouse operations by supervising production, ensuring safety, and enhancing team performance. Collaborate with cross-functional partners to optimize processes and maintain inventory accura...

Today

  •   Less than 5 years exp.  •   Healthcare

$68K - $120K *

Lead the charge in managing oncology clinical trials, ensuring efficient operations, compliance, and stakeholder engagement throughout the trial lifecycle while collaborating with various teams and ma...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$134K - $162K *

Champion the adoption of innovative cardiovascular therapies by engaging healthcare providers through scientific dialogue and tailored customer experiences, driving demand and ensuring optimal patient...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$98K - $163K *

Transform data insights into actionable strategies by leading advanced analytics initiatives. Collaborate with cross-functional teams to enhance provider relations through innovative dashboards and re...

Today

  •   5 - 7 years exp.  •   Healthcare

$98K - $163K *

Transform data insights into actionable strategies by leading analytics initiatives, developing dashboards, and collaborating with cross-functional teams to enhance provider operations and decision-ma...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$88K - $105K *

Lead strategic pitch support initiatives, enhancing presentation effectiveness and driving customer engagement through storytelling and collaboration across teams. Manage multiple projects while ensur...

Today

  •   5 - 7 years exp.  •   Healthcare

$110K - $150K *

Empower early talent recruitment by leading a dynamic screener team. Drive application reviews, maintain selection standards, and ensure timely candidate decisions while collaborating closely with lea...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$157K - $212K *

Join a team that's dedicated to leading complex projects and programs. You'll analyze risks, develop integrated plans, and foster relationships with stakeholders to ensure successful execution and com...

Today

  •   5 - 7 years exp.  •   Aerospace & Defense

$198K - $269K *

Shape the future of aerospace by leading a dynamic team in sustaining F/A-18 operations. Drive engineering excellence, ensure safety, and collaborate with cross-functional teams to deliver top-tier su...

Today

  •   8 - 10 years exp.  •   Aerospace & Defense

$108K - $137K *

Lead operational excellence by managing program reporting and incentives. Drive medium-to-large projects from inception to completion, enhancing productivity and collaboration across teams while imple...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$140K - $164K *

Develop and lead a high-performing sales team to drive national corporate growth, aligning strategies and processes to achieve ambitious revenue targets while fostering a culture of accountability and...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Hospitality & Recreation

$77K - $95K *

Optimize cloud operations by managing and enhancing cloud compute systems. Collaborate with teams to ensure efficient capacity planning, alert monitoring, and customer support, while driving continuou...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$115K - $160K *

Transform client relationships by driving strategic growth and innovative solutions. Leverage your expertise in AI and technology to identify opportunities, shape proposals, and ensure successful deli...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$165K - $190K *

Optimize cloud infrastructure and automate processes as a DevOps Engineer. Collaborate with cross-functional teams to enhance system reliability, scalability, and security while driving developer effi...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.