Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$95K - $115K *

Manage a team of security and network professionals to ensure robust cybersecurity and network performance. Collaborate with IT leaders to develop scalable solutions, oversee incident response, and ma...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$96K - $120K *

Lead the charge in electric resource planning, optimizing generation strategies and ensuring compliance with regulatory requirements while collaborating across departments to deliver reliable energy s...

4 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$61K - $101K *

Transform workplace safety by consulting with employers, conducting evaluations, and developing loss control strategies. Collaborate with clients to enhance safety practices and ensure compliance, whi...

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Drive multi-year program management for District Civil Works, coordinating budgets, schedules, and technical advice to enhance project execution and stakeholder engagement while ensuring compliance wi...

4 days ago

  •   Less than 5 years exp.  •   Technical Services

$80K - $100K *

Join a team that's driving impactful client strategies in digital marketing. As a Supervisor, you'll lead a dynamic team, manage client relationships, and oversee integrated campaigns across omnichann...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$66K - $208K *

Innovate content strategies by managing legal updates and blogs, ensuring timely, polished, and SEO-optimized thought leadership. Collaborate with attorneys and teams to enhance content quality and dr...

4 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$102K - $208K *

Help us elevate our content strategy by managing legal updates and blog content from inception to publication, ensuring high-quality, SEO-optimized thought leadership that engages clients and prospect...

4 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$102K - $208K *

Transform the content landscape by managing legal updates and blog content, ensuring timely, polished, and SEO-optimized publications. Collaborate with attorneys and teams to enhance thought leadershi...

4 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$102K - $208K *

Empower our content strategy by managing legal updates and blog content from inception to publication. Collaborate with attorneys and teams to ensure high-quality, SEO-optimized thought leadership tha...

4 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$148K - $263K *

Drive the design and implementation of AI-First operational environments, architecting resilient multi-cloud networks and building autonomous orchestration layers to enhance security and efficiency ac...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$161K - $299K *

Transform healthcare contracting by developing strategies, negotiating reimbursement agreements, and ensuring network adequacy for commercial and government providers. Lead a team to achieve operation...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Healthcare

$90K - $110K *

Lead IT support initiatives to ensure optimal performance of bot infrastructure. Manage setup, monitoring, and uptime of machines while growing a dedicated team within the Customer Success division. D...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$64K - $109K *

Transform patient care by coordinating clinical activities, managing communications, and ensuring seamless operations in a supportive environment. Collaborate with healthcare teams to enhance patient...

4 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$117K - $195K *

Champion innovation by leading software verification and validation efforts for critical aerospace projects. Collaborate with cross-functional teams to ensure flight software meets rigorous standards...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$88K - $132K *

Transform employee relations by providing expert guidance, resolving complex issues, and fostering a positive work environment. Collaborate with management to enhance performance and retention while e...

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$128K - $252K *

Unlock your potential as a Senior Consultant in Life Sciences, driving Market Access strategies and delivering actionable insights for clients. Collaborate with industry leaders to enhance pricing, re...

4 days ago

  •   5 - 7 years exp.  •   Business Services

$128K - $252K *

Join a dynamic team as you support Market Access initiatives, driving pricing and reimbursement strategies for Life Sciences clients. Collaborate with industry leaders to deliver actionable insights a...

4 days ago

  •   5 - 7 years exp.  •   Business Services

$145K - $175K *

Unlock customer success by designing impactful journeys that enhance retention and revenue. As a key contributor, you'll shape service blueprints and orchestrate cross-functional teams to drive measur...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$145K - $175K *

Shape the future of cybersecurity by leading Zero Trust architecture initiatives. Drive enterprise-wide strategies, develop reusable patterns, and ensure alignment with federal standards while guiding...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$87K - $157K *

Lead the charge in managing third-party program relationships, ensuring performance standards and financial accountability while facilitating effective communication between Delegation partners and in...

Missouri, USRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $155K *

Elevate your career by designing and training advanced machine learning models. Collaborate with experts to analyze data, create reinforcement learning environments, and communicate findings effective...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $197K *

Elevate the future of medical science by engaging with healthcare professionals, driving strategic insights, and fostering scientific relationships to enhance clinical practices and medical knowledge...

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$76K - $186K *

Join us in driving financial planning and forecasting to enhance Revenue, Billings, and Cash Flow. Collaborate with teams to create accurate models and provide insights that shape strategic decisions...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Join a team that's pioneering biomarker research in oncology clinical studies. Drive innovative strategies, collaborate with experts, and contribute to the development of transformative therapies that...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$143K - $165K *

Lead the design and delivery of enterprise technology solutions, driving innovation and growth. Oversee product lifecycles, mentor teams, and collaborate with stakeholders to ensure high-quality, scal...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.