Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$85K - $105K *

Join our team to drive client success for mid-market RIAs. You'll manage relationships, ensure adoption, and facilitate growth through strategic guidance and training, all while collaborating with cro...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$75K - $126K *

Shape the future of talent acquisition by leading full-cycle recruitment for data and IT roles. Collaborate with hiring teams to enhance candidate experiences and drive continuous improvement in recru...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $105K *

Drive your career forward by executing hands-on projects in a dynamic privacy landscape. Collaborate with a remote team to navigate compliance challenges while enhancing your expertise through continu...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$103K - $140K *

Shape the future of finance data by collaborating with stakeholders to build reliable data models that enhance reporting and decision-making. Drive analytics projects from inception to delivery, ensur...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $105K *

Lead the charge in enhancing partner success through strategic support, operational excellence, and relationship management. Collaborate with cross-functional teams to ensure partner engagement and sa...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$75K - $90K *

Transform partner engagement by activating and growing low-performing distribution partners. Drive adoption and integration through training and outreach, fostering strong relationships to enhance pro...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in executing Proof of Value engagements, demonstrating the Tanium platform's capabilities while collaborating with account teams to align with customer objectives and drive successful...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $175K *

Join a team that's shaping the future of power generation by leading schedule management across all project phases, ensuring timely delivery and compliance with contractual obligations...

4 days ago

  •   5 - 7 years exp.  •   Technical Services

$117K - $176K *

Empower your career by leading cross-functional teams to craft compelling narratives that drive strategic pursuits. Utilize your expertise in clinical development and storytelling to enhance customer...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $150K *

Transform accounting operations by bridging customer workflows and AI-driven solutions. Engage in pre-sale discovery, design automated solutions, and ensure accurate implementation, all while collabor...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $158K *

Engage as a Technical Lead to drive Hadoop solutions, leveraging expertise in data management and analytics. Collaborate with teams to enhance data quality and performance, ensuring effective ETL proc...

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$88K - $105K *

Join a dynamic team to optimize Oracle applications, analyze user needs, and design effective system solutions. Leverage your expertise to enhance operational efficiency and support mission-driven ini...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$108K - $130K *

Drive excellence in aviation operations by overseeing JPATS Flight Operations. Lead scheduling, training, and safety initiatives while ensuring compliance with FAA regulations. Your leadership will en...

4 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$98K - $147K *

Unlock potential by leading the design and implementation of HVAC control systems for data centers. Drive reliability and efficiency through the entire controls lifecycle, ensuring seamless integratio...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $140K *

Transform operational and technology risk management through AI-driven solutions, enhancing efficiency and value across processes. Lead comprehensive risk programs, ensuring robust oversight and proac...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Transform technology solutions by collaborating with cross-functional teams to enhance partner integrations and connected services, driving innovation and operational efficiency within the fleet ecosy...

4 days ago

  •   Less than 5 years exp.  •   Transportation

$102K - $147K *

Drive new business opportunities by cultivating relationships with C-level executives. Own the full sales cycle for Large Enterprise clients, ensuring value delivery and exceeding sales targets while...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Business Services

$100K - $120K *

Transform campus IT operations by leveraging Microsoft 365 solutions, automating workflows, and enhancing endpoint management. Collaborate with stakeholders to deliver tailored solutions that drive ef...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$71K - $106K *

Empower our nursing team to deliver exceptional, patient-centered care by assessing needs, managing medications, and collaborating with multidisciplinary teams. Your expertise will enhance patient out...

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$183K - $229K *

Drive the evolution of AI architecture, enabling teams to build scalable AI solutions on a robust platform. Collaborate with product teams to translate roadmaps into actionable designs, ensuring high...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Technical Services

$80K - $95K *

Champion the design and configuration of Ellucian Colleague Financial Aid systems, ensuring alignment with client strategies while providing expert technical support and training to enhance operationa...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$200K *

Drive sales of diagnostic imaging services by managing the full sales cycle, from prospecting to closing. Collaborate with stakeholders to build business cases and implement solutions, while maintaini...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $135K *

Shape the future of digital services by developing user-centric applications and enhancing software engineering practices. Collaborate with cross-functional teams to deliver impactful solutions for fe...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$170K - $200K *

Unlock potential by leading enterprise architecture and AI integration strategies. Collaborate with IT and business leaders to drive innovation, enhance scalability, and ensure governance across techn...

4 days ago

  •   8 - 10 years exp.  •   Food & Beverages

$110K - $130K *

Manage and grow large enterprise accounts, developing C-level relationships and driving sales of technology solutions to enhance business continuity and disaster recovery efforts across organizations...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.