Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $116,335
Program Manager, Operations Process
$110K - $130K *
Join a dynamic team to enhance operational workflows for autonomous trucking. Lead process design, maintain quality standards, and drive continuous improvement across multiple workstreams while collab...
Today
$135K - $176K *
Join a team that's dedicated to enhancing financial accuracy and compliance. Collaborate with finance leaders to improve reporting processes, assist with audits, and analyze data, all while managing m...
Today
Solutions Consultant, Commercial
$115K - $159K *
Join a team that's dedicated to driving customer success through tailored financial solutions, utilizing technical expertise and effective collaboration within a fast-paced environment to meet evolvin...
Reposted today
Senior Manager, Regulatory Affairs Labeling
$150K - $189K *
Transform global labeling strategies into actionable regional plans, ensuring compliance and quality. Oversee document preparation, vendor management, and cross-functional approvals to deliver timely...
Today
Sr. Software Developer - C#/WPF for UI/UX Development
$123K - $202K *
Join our agile team to design and develop cutting-edge Esri software for raster and imagery workflows in ArcGIS Pro using C#, WPF, and C++. Collaborate to create innovative user interfaces while ensur...
Reposted today
Sr. GIS Solution Engineer - AEC
$98K - $173K *
Empower businesses by leveraging GIS technology to solve complex spatial challenges. As a geospatial expert, engage with clients to demonstrate innovative solutions and strategies that drive impactful...
Reposted today
Contractor Program Security Officer (CPSO) - TS/SCI
$93K - $158K *
Support critical national security missions by managing program security requirements, collaborating with government customers, and ensuring compliance in classified environments to enable secure miss...
Reposted today
$160K - $195K *
Shape the future of payroll and HRIS integrations by ensuring reliability and success. Collaborate with customers and partners to solve technical challenges and enhance the integration experience whil...
Reposted today
$72K - $109K *
Execute inventory management strategies to enhance supply chain efficiency, ensuring optimal service levels and minimal spoilage. Collaborate with teams to maintain accurate purchasing and inventory c...
Today
Partner 20, Social Media Lead, Frontier
$199K - $232K *
Unlock potential by driving social media strategy and engagement across diverse platforms. Collaborate with teams to create compelling content, analyze performance, and enhance brand presence while ad...
Reposted today
Member Experience Specialist - Tampa Bay Area
$85K - $105K *
Provide exceptional frontline support to members, ensuring seamless navigation through healthcare complexities. Collaborate cross-functionally to resolve issues and enhance overall member experience t...
Reposted today
$72K - $109K *
Engage in optimizing inventory management strategies to enhance customer service and minimize spoilage. Collaborate with teams to ensure efficient supply chain operations while achieving key performan...
Today
$120K - $145K *
Pioneer the future of technical content as you drive strategy and execution for Render's content factory, ensuring accuracy and relevance for AI agents and developers. Collaborate closely with teams t...
Today
Staff Product Manager, BioPharma Platforms
$146K - $224K *
Elevate clinical development by leading the strategy for biopharma platforms. Drive product lifecycles, collaborate with cross-functional teams, and ensure compliance while transforming workflows into...
Reposted today
Medical Director - Inpatient Review
$223K - $313K *
Join a distinguished team of physicians to enhance inpatient care quality through expert clinical reviews and utilization management, impacting patient outcomes while enjoying a structured, collaborat...
Today
$90K - $110K *
Shape user experiences by designing intuitive interfaces for a cutting-edge security platform. Collaborate with engineers to create impactful visual workflows, leveraging modern technologies to enhanc...
Reposted today
Director of Product & Delivery Management
$180K - $205K *
Transform the landscape of product delivery in government, leading a dynamic team of Product and Delivery Managers to enhance public service efficacy through innovative practices and capacity building...
Reposted today
GTM Solutions Management Director
$107K - $143K *
Advance your career by driving strategic GTM solutions, aligning cross-functional teams, and optimizing sales processes to enhance pipeline performance and bookings outcomes in a dynamic environment...
Today
SAP Finance Consultant - 100% onsite in St. Louis, MO
$103K - $295K *
Champion SAP Finance solutions by leading design, configuration, and testing efforts. Collaborate with cross-functional teams to enhance financial processes and mentor junior consultants, ensuring ali...
Reposted today
SAP Procurement Consultant - Onsite in St. Louis, Philadelphia, Arlington, or Huntington Beach
$103K - $196K *
Lead the charge in optimizing SAP S/4HANA procurement processes within a classified aerospace and defense environment, ensuring effective operations and supporting future program enhancements through...
Reposted today
IT System Administrator - SOC/NOC Support
$106K - $221K *
Drive the future of cybersecurity by managing SOC/NOC tools, optimizing performance, and implementing security controls to ensure robust system operations and compliance with best practices...
Today
SAP Data Migration Consultant - 100% onsite in St. Louis, MO
$106K - $206K *
Drive data migration excellence by leading end-to-end SAP S/4HANA initiatives. Collaborate with cross-functional teams to ensure accurate data loads and implement best practices in data governance and...
Reposted today
SAP Warehouse Management (WM) Consultant - 100% onsite in St. Louis, MO
$92K - $224K *
Engage in end-to-end SAP WMS solutions, drive client workshops, configure systems, and lead teams to enhance warehouse operations seamlessly while ensuring integration and mentoring junior consultants...
Reposted today
$120K - $145K *
Champion data excellence by designing and optimizing scalable data platforms. Collaborate with cross-functional teams to enhance performance and drive innovation in data processing, ensuring alignment...
Today
Tier 2 Product Owner - Oracle SCM & Fleet Management
$95K - $115K *
Drive product ownership and functional support for Oracle Fusion SCM and Fleet Management. Collaborate with stakeholders to resolve complex issues, enhance processes, and shape the product roadmap whi...
Reposted today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.