Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$125K - $150K *

Transform technology strategy across a dynamic manufacturing organization. Lead initiatives in cybersecurity, infrastructure, and digital transformation while aligning IT investments with business goa...

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $165K *

Drive strategic growth by acquiring new logos and expanding partnerships within large health systems. Navigate complex sales cycles, build executive relationships, and enhance enterprise value through...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $95K *

Elevate your career by joining a dedicated team focused on optimizing rehabilitative outcomes for patients with physical impairments in a supportive skilled nursing facility environment...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Lead the charge in managing logistics operations, ensuring compliance with DOT regulations while overseeing a team of supervisors and logistics associates to optimize transportation efficiency and saf...

2 days ago

  •   5 - 7 years exp.  •   Transportation

$110K - $130K *

Transform product strategy and delivery by leading cross-functional teams to enhance Revenue Management solutions, driving innovation and measurable business value in a dynamic environment...

2 days ago

  •   5 - 7 years exp.  •   Transportation

$80K - $95K *

Join a team that's dedicated to excellence in marine engineering, supervising vessel maintenance and leading projects to ensure fleet reliability while developing specifications and solutions that enh...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Transportation

$70K - $95K *

Unlock potential by leveraging data insights to drive scalable growth and enhance sales team performance. Collaborate with leadership to develop strategies that improve productivity and operational ef...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Transportation

$100K *

Drive sales growth by engaging clients, providing insurance solutions, and ensuring exceptional service. Leverage your competitive spirit to meet targets while maintaining compliance and documentation...

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$85K - $95K *

Empower your career as a Senior Business Intelligence Analyst, modernizing data extraction and automation. Collaborate across teams to deliver actionable insights using AI and BI tools, ensuring clari...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Media

$80K - $95K *

Unlock your potential as a Lead Clinical Document Specialist, addressing urgent CDI issues and driving documentation integrity across departments. Collaborate on strategic initiatives, mentor teams, a...

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Transform complex security architectures into compelling business narratives that resonate with enterprise decision-makers. Collaborate across teams to drive product positioning, messaging, and go-to...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$106K - $133K *

Champion client success by leading complex upskilling programs, coordinating cross-functional teams, and ensuring seamless delivery of diverse learning solutions tailored to enterprise needs...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Business Services

$140K *

Serve as a strategic financial leader, guiding budgeting, forecasting, and analysis to drive profitability and operational efficiency across the organization. Collaborate with executives to translate...

2 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$100K - $120K *

Grow your career with a leadership role overseeing air traffic control operations. Lead a team of specialists, manage workflow, and enhance operational efficiency while ensuring compliance with safety...

2 days ago

  •   Less than 5 years exp.  •   Transportation

$163K - $413K *

Champion transformative SAP Finance solutions by leading large-scale projects, engaging with senior executives, and driving innovative strategies that enhance client outcomes and business value across...

2 days ago

  •   11 - 15 years exp.  •   Business Services

$108K - $125K *

Champion innovative solutions as a Full Stack Engineer, delivering impactful features and enhancing systems across projects. Collaborate, design, and optimize applications with a focus on performance...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $140K *

Lead the charge in delivering enterprise data platform initiatives, managing Agile processes, and ensuring effective collaboration across teams. Drive project execution from discovery to deployment wh...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$122K - $175K *

Unlock potential by leading the design and maintenance of scalable cloud infrastructure. Drive innovation in cloud technologies, ensuring robust security and efficient deployment while collaborating w...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $100K *

Advance mental health services by leading a dedicated team, ensuring quality care and compliance with VA standards. Provide comprehensive psychological assessments and interventions for veterans, fost...

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$175K - $243K *

Engage with enterprise merchants to architect scalable solutions, leveraging technical expertise and collaboration across teams. Drive pre-sale activities, build trust, and influence product developme...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$97K - $136K *

Oversee and enhance Behavioral Health programs, ensuring quality patient care and compliance. Lead a dedicated team, develop strategic initiatives, and integrate services to meet diverse patient needs...

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Elevate clinical operations by providing strategic leadership and oversight for nursing services, ensuring high-quality, patient-centered care while aligning with organizational goals and regulatory s...

2 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$191K - $260K *

Drive ERP strategy and modernization initiatives, collaborating with leaders to ensure technology investments yield significant business value and enhance operational efficiency across the organizatio...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $150K *

Lead the charge in operational oversight of clinical laboratory services, ensuring compliance with regulatory standards while promoting high-quality, cost-effective testing. Collaborate with healthcar...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$92K - $160K *

Engage with local agencies to drive revenue growth through strategic partnerships. Leverage your expertise in digital sales and agency relations to cultivate relationships, exceed sales targets, and r...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.