Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$88K - $105K *

Lead integration efforts to enhance supply chain operations in healthcare, bridging clinical and administrative functions. Drive strategic initiatives, optimize team performance, and ensure alignment...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Drive impactful financial reporting and analysis for Medicare and Medicaid, ensuring compliance and accuracy in cost reports and funding applications while collaborating with various stakeholders to e...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $220K *

Engage with Enterprise customers as a Senior Solutions Engineer, driving strategic outcomes through collaboration with sales teams. Leverage technical expertise and business acumen to influence decisi...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Lead the charge in shaping nationwide multifamily housing policies and operations. Oversee a dedicated team, ensuring effective loan servicing and property management while driving program improvement...

2 days ago

  •   Less than 5 years exp.  •   Transportation

$100K - $120K *

Help us shape the future of construction financing by leveraging your experience in loan origination. Join our dynamic team and gain direct access to a nationwide market, empowering clients with tailo...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $120K *

Optimize clinical trial operations by managing study components, ensuring compliance, and collaborating with cross-functional teams to deliver high-quality results on time and within budget...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join a team that's dedicated to ensuring accurate and timely prescription fulfillment while adhering to regulations. Collaborate with healthcare professionals to enhance patient safety and optimize ph...

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$200K - $265K *

Empower clients by showcasing the Neo4j Graph Intelligence Platform, driving technology evaluations, and delivering tailored solutions that address critical business needs while fostering strong custo...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$163K - $413K *

Lead the charge in optimizing client relationships and driving sales growth within Residential Lending. Utilize your expertise to manage dedicated teams, deliver innovative solutions, and ensure profi...

2 days ago

  •   8 - 10 years exp.  •   Business Services

$320K - $340K *

Join us to lead the Utilization Management team, ensuring timely, evidence-based medical necessity decisions while managing a team of Medical Directors and collaborating across clinical programs to en...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $125K *

Champion the resolution of complex professional liability claims by analyzing, negotiating, and coordinating case management to ensure timely and effective outcomes while maintaining strong client rel...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$70K - $205K *

Empower your career by delivering SAP Utilities transformation programs. Leverage your SAP IS-U Billing expertise to modernize utility billing processes, ensuring regulatory compliance and enhancing c...

2 days ago

  •   Less than 5 years exp.  •   Business Services

$80K - $105K *

Unlock potential by managing user requirements for Air Force projects. Collaborate with stakeholders, facilitate Agile ceremonies, and ensure clear communication throughout the software development li...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $140K *

Join a dynamic team as you shape product strategy and drive innovation in assessment solutions. Collaborate with cross-functional teams to enhance user experiences and leverage emerging technologies f...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$230K - $250K *

Lead the charge in driving new business with health plans, leveraging expertise to build relationships and close complex deals. Collaborate with cross-functional teams to deliver tailored solutions an...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Join a team that's shaping the future of enterprise solutions by leveraging your technical expertise to deliver high-quality Open Text implementations for enterprise clients, ensuring tailored solutio...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$121K - $155K *

Champion the creative development process, collaborating with teams to deliver compelling concepts and strategic narratives. Mentor junior staff while ensuring client communication and project executi...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$87K - $120K *

Champion our legal team by providing expert guidance on employment and labor matters, ensuring compliance and risk management across diverse jurisdictions while collaborating with HR and business lead...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Transportation

$80K - $95K *

Take ownership of high-impact surveying projects while mentoring teams and ensuring technical excellence. Lead initiatives to expand client bases and enhance capabilities, shaping the future of our pr...

2 days ago

  •   8 - 10 years exp.  •   Technical Services

$89K - $118K *

Unlock potential by leading business and technology teams to deliver AI and application solutions. Drive value realization through strategic partnerships, governance, and continuous improvement in a h...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K *

Unlock your potential in pharmacy benefits consulting through a hands-on fellowship. Gain invaluable experience in client strategy, data analytics, and emerging therapies while shaping the future of p...

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $110K *

Grow your career with impactful project management in global health initiatives. Lead diverse teams across 20-25 countries, ensuring effective execution of polio and health security programs while fos...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$210K - $250K *

Elevate your career by delivering exceptional outpatient and inpatient care within a supportive team. Enjoy a balanced schedule with no overnight coverage, while building lasting patient relationships...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$73K - $132K *

Unlock potential by leading the ServiceNow product backlog, collaborating with stakeholders, and enhancing Agile practices to drive platform capabilities and deliver business value effectively...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Technical Services

$110K - $130K *

Empower innovation by leading complex structural projects, guiding teams, and building trusted client relationships. Drive strategic growth and influence industry standards while shaping the future of...

2 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.