Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$160K - $175K *

Accelerate progress at driving sales growth by leading a dynamic team, implementing strategic initiatives, and enhancing customer experiences across multiple product categories in a high-impact region...

2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$150K - $160K *

Elevate your legal career by driving commercial contracting and negotiations. Collaborate with sales and stakeholders to enhance processes and policies, ensuring scalable legal support in a dynamic en...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$160K - $175K *

Drive sales growth by leading a dynamic team, implementing strategies, and leveraging technology to enhance customer experience and market penetration in a key region...

2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$88K - $105K *

Unlock potential by managing air quality projects, ensuring compliance with regulations, and guiding clients through emissions evaluations and sustainability reporting while mentoring a skilled team o...

2 days ago

  •   5 - 7 years exp.  •   Technical Services

$120K - $145K *

Champion the enhancement of cryptographic platforms, driving system integration and automation while preparing for industry changes. Collaborate with teams to optimize workflows and manage engineering...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $160K *

Advance HR technology by leading Workday administration, ensuring optimal system performance, security, and data governance. Collaborate with HR and IT to deliver solutions that enhance business proce...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Staffing

$126K - $137K *

Drive innovation by designing and developing mobile applications that enhance user experiences. Collaborate across the software lifecycle to deliver high-quality solutions, leveraging modern technolog...

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Join a team that's driving commercial success by leading a U.S.-based account management team, optimizing strategies, and enhancing stakeholder engagement to achieve business objectives and foster reg...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$76K - $114K *

Join a dynamic team to provide clinical support and training for innovative neuromodulation therapies. Collaborate with sales to enhance patient care and ensure successful product utilization, while m...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$116K - $210K *

Elevate the quality of healthcare technology by leading test strategy and execution for a modernized EHR system. Collaborate with teams to ensure compliance, validate requirements, and enhance user ex...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Technical Services

$82K - $149K *

Unlock potential by providing logistics expertise for critical Air Force systems. Collaborate with multi-disciplined teams to optimize resource flow, manage international shipments, and ensure success...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Technical Services

$75K - $95K *

Grow your career by providing exceptional PM&R services in collaboration with an interdisciplinary team. Help enhance patient independence and quality of life at a dedicated rehab center, focusing on...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $150K *

Engineer complex fund relationships by leading technical accounting and administration for closed-end private equity and real estate. Collaborate with stakeholders to ensure accurate reporting and com...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K *

Grow your career with a dynamic sales role focused on lead generation, client retention, and exceeding targets. Enjoy a competitive earning potential and comprehensive benefits while building a profit...

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$313K - $431K *

Unlock your potential by leading clinical innovation and transformation. Collaborate with diverse teams to enhance care delivery, optimize practices, and drive measurable improvements in quality and p...

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Join a team that's dedicated to enhancing specialty pharmacy services by analyzing trends, identifying barriers, and driving operational efficiencies to maximize prescription capture and improve patie...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$72K - $104K *

Unlock potential by driving operational excellence in sales support, ensuring contract accuracy, and enhancing partner onboarding. Collaborate with teams to monitor project status and deliver insightf...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$87K - $253K *

Join our team to lead life sciences commercial transformations through AI-enabled solutions. Drive innovative workflows, governance, and strategies that create measurable value across various commerci...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Business Services

$59K - $177K *

Transform finance operations by leveraging SAP S/4HANA expertise to deliver tailored solutions, engage stakeholders, and drive enterprise value through innovative finance processes and cross-functiona...

2 days ago

  •   Less than 5 years exp.  •   Business Services

$165K - $195K *

Lead innovative solution development for Federal Government projects, translating client needs into effective strategies. Collaborate with cross-functional teams to deliver compelling proposals and en...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $110K *

Unlock potential by driving sales growth in the Eastern US for innovative testing products. Collaborate with teams to develop strategies, maintain customer relationships, and achieve revenue targets i...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Join a team that's dedicated to enhancing public safety through innovative technology. In this impactful role, you'll engage with key stakeholders to drive sales and expand our presence in the emergen...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Advance your career by leading strategic transformation in building science, bridging R&D, marketing, and commercial teams to establish technical authority in building envelope performance and drive i...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$107K - $159K *

Drive innovative electrical engineering solutions for diverse projects, ensuring compliance with industry standards while leading teams and mentoring junior engineers to achieve client objectives and...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Technical Services

$150K - $200K *

Deliver exceptional HVAC solutions by building relationships with homeowners. Evaluate needs, present options, and ensure a seamless customer experience while achieving sales goals in a dynamic, commi...

2 days ago

  •   Less than 5 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.