Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$95K - $115K *

Pioneer data-driven decision-making by analyzing operational metrics and financial performance. Collaborate with leadership to enhance efficiency and drive continuous improvement in a fast-paced manuf...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$67K - $107K *

Join a team that's dedicated to optimizing patient transfer logistics and enhancing care continuity. Collaborate with healthcare professionals to ensure timely access and appropriate bed assignments w...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $173K *

Transform operational excellence by driving compliance and standardization across Plasma Procurement. Collaborate with leaders to enhance processes, implement Lean practices, and foster a culture of c...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead the charge in designing and implementing enterprise-grade data archival solutions. Oversee end-to-end delivery, ensuring compliance with security standards while collaborating across teams to opt...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$59K - $106K *

Unlock potential by joining a dynamic team that leverages GIS expertise to support national security initiatives. Collaborate on cartographic production and analysis, ensuring high-quality geospatial...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Technical Services

$140K - $165K *

Drive the development and continuous improvement of a unified Quality Management System across global manufacturing sites, ensuring compliance, scalability, and alignment with ISO standards while coll...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$142K - $228K *

Join a team that's shaping the future of corporate governance and compliance! In this role, you'll provide strategic legal guidance, mitigate risks, and ensure adherence to laws, driving operational e...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$312K - $446K *

Lead a high-performing team to drive strategic growth in defense and intelligence markets. Oversee opportunity identification, partner engagement, and pipeline development, ensuring disciplined execut...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Information Technology

$80K - $95K *

Drive building performance and energy efficiency by conducting assessments, audits, and evaluations for diverse properties. Collaborate with clients to enhance sustainability and reduce operational co...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$121K - $185K *

Lead the charge in the design and optimization of complex systems, ensuring seamless integration and performance to achieve mission success while collaborating with multidisciplinary teams and stakeho...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$88K - $105K *

Join our dynamic team to design electrical systems for diverse industries, ensuring precision and innovation in every project while collaborating closely with cross-functional teams and clients...

Reposted 2 days ago

  •   8 - 10 years exp.  •   Technical Services

$125K - $150K *

Drive channel sales success by defining and executing programs that recruit, activate, and grow Trusted Advisors. Collaborate across teams to enhance performance, communication, and operational effici...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$130K - $200K *

Unlock potential by enhancing our data infrastructure. In this role, you'll own data pipelines, improve performance, and ensure reliable access to analytics across global markets, driving efficiency a...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$164K - $235K *

Shape the future of security architecture for agentic AI systems by creating and implementing robust, secure solutions that empower innovative applications and ensure data safety in a collaborative, f...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Optimize supply chain operations by negotiating IT contracts and fostering collaboration across teams to enhance healthcare delivery and reduce costs. Drive strategic sourcing initiatives while ensuri...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Grow your career with a dynamic engineering team, providing architectural leadership for Java microservices and cloud-native applications while fostering collaboration and continuous growth in a fast...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Contribute to a transformative social care strategy that integrates community support into clinical workflows, enhancing patient care and addressing social determinants of health through innovative pa...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Lead the charge in optimizing revenue performance by analyzing reimbursement trends, collaborating with teams to resolve discrepancies, and driving strategic initiatives to enhance financial outcomes...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to excellence in risk management by supervising and mentoring a skilled group of Claims Specialists. Drive operational success through performance evaluations and expert g...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Shape the future of network security by leading global architecture, optimizing firewall ecosystems, and aligning strategies with cross-functional teams to enhance organizational security standards an...

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$159K - $287K *

Drive growth and lead strategic partnerships as you oversee P&L performance and business strategy for key global accounts, ensuring operational excellence and customer satisfaction while managing high...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$95K - $115K *

Transform the learner experience by owning business and functional requirements for custom LMS and LCMS platforms. Drive modernization and compliance while collaborating with cross-functional teams to...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$116K - $140K *

Advance your career as you lead transformative Oracle solutions, architecting scalable designs that drive business value. Collaborate with clients and teams to deliver innovative strategies across HCM...

2 days ago

  •   8 - 10 years exp.  •   Business Services

$273K - $380K *

Take ownership of building innovative enterprise partnerships that embed financial solutions in leading platforms. Drive strategic deals, capitalize on your industry network, and structure first-of-a...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$122K - $261K *

Lead the charge in architecting comprehensive SAP data migration strategies for S/4HANA transformations. Drive success through hands-on execution, mentoring teams, and engaging with stakeholders to en...

2 days ago

  •   8 - 10 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.