Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Human Resources Business Partner (Remote)
$180K - $220K *
Join a team that partners with leaders to enhance organizational performance, drive employee engagement, and implement talent development initiatives in a fast-paced, global environment while supporti...
Reposted 2 days ago
Senior Enterprise Account Executive
$300K - $350K *
Transform enterprise sales by expanding Fortune 100 accounts across North America. Collaborate with cross-functional teams to drive growth, enhance customer relationships, and leverage a unique cybers...
2 days ago
Staff Software Engineer, Autonomous Vehicle Performance Metrics
$172K - $229K *
Join a dynamic team to enhance autonomous vehicle performance through innovative software tools and metrics. Collaborate cross-functionally to drive technical strategy and ensure data quality, contrib...
2 days ago
Economics PhD, Internship - Summer 2027
$83K *
Engage in innovative economic research by supporting empirical analysis and developing a research paper with a supervising economist during a ten-week paid internship...
2 days ago
Business Development Manager - Western Region
$106K - $146K *
Accelerate sales growth by engaging clients, shaping strategies, and delivering tailored solutions through collaboration with technical teams, ensuring customer satisfaction and fostering long-term re...
Reposted 2 days ago
$95K - $115K *
Pioneer data-driven decision-making by analyzing operational metrics and financial performance. Collaborate with leadership to enhance efficiency and drive continuous improvement in a fast-paced manuf...
Reposted 2 days ago
Registered Nurse (RN) - Transfer Center Specialist - Conduit Health Partners
$67K - $107K *
Join a team that's dedicated to optimizing patient transfer logistics and enhancing care continuity. Collaborate with healthcare professionals to ensure timely access and appropriate bed assignments w...
2 days ago
Performance Excellence Manager
$115K - $173K *
Transform operational excellence by driving compliance and standardization across Plasma Procurement. Collaborate with leaders to enhance processes, implement Lean practices, and foster a culture of c...
Reposted 2 days ago
Data Archival & ETL Architect | Remote | 6+ Months
$120K - $145K *
Lead the charge in designing and implementing enterprise-grade data archival solutions. Oversee end-to-end delivery, ensuring compliance with security standards while collaborating across teams to opt...
2 days ago
$59K - $106K *
Unlock potential by joining a dynamic team that leverages GIS expertise to support national security initiatives. Collaborate on cartographic production and analysis, ensuring high-quality geospatial...
Reposted 2 days ago
$140K - $165K *
Drive the development and continuous improvement of a unified Quality Management System across global manufacturing sites, ensuring compliance, scalability, and alignment with ISO standards while coll...
2 days ago
Country Corporate Counsel - US
$142K - $228K *
Join a team that's shaping the future of corporate governance and compliance! In this role, you'll provide strategic legal guidance, mitigate risks, and ensure adherence to laws, driving operational e...
Reposted 2 days ago
Director, Business Development
$312K - $446K *
Lead a high-performing team to drive strategic growth in defense and intelligence markets. Oversee opportunity identification, partner engagement, and pipeline development, ensuring disciplined execut...
2 days ago
$80K - $95K *
Drive building performance and energy efficiency by conducting assessments, audits, and evaluations for diverse properties. Collaborate with clients to enhance sustainability and reduce operational co...
2 days ago
Systems Engineer (Experienced OR Lead)
$121K - $185K *
Lead the charge in the design and optimization of complex systems, ensuring seamless integration and performance to achieve mission success while collaborating with multidisciplinary teams and stakeho...
Reposted 2 days ago
Electrical Engineer/Designer - MEP
$88K - $105K *
Join our dynamic team to design electrical systems for diverse industries, ensuring precision and innovation in every project while collaborating closely with cross-functional teams and clients...
Reposted 2 days ago
$125K - $150K *
Drive channel sales success by defining and executing programs that recruit, activate, and grow Trusted Advisors. Collaborate across teams to enhance performance, communication, and operational effici...
2 days ago
$130K - $200K *
Unlock potential by enhancing our data infrastructure. In this role, you'll own data pipelines, improve performance, and ensure reliable access to analytics across global markets, driving efficiency a...
2 days ago
Security Architect / Security Engineer
$164K - $235K *
Shape the future of security architecture for agentic AI systems by creating and implementing robust, secure solutions that empower innovative applications and ensure data safety in a collaborative, f...
Reposted 2 days ago
$80K - $95K *
Optimize supply chain operations by negotiating IT contracts and fostering collaboration across teams to enhance healthcare delivery and reduce costs. Drive strategic sourcing initiatives while ensuri...
2 days ago
$120K - $145K *
Grow your career with a dynamic engineering team, providing architectural leadership for Java microservices and cloud-native applications while fostering collaboration and continuous growth in a fast...
2 days ago
Senior Director Community Impact
$125K - $150K *
Contribute to a transformative social care strategy that integrates community support into clinical workflows, enhancing patient care and addressing social determinants of health through innovative pa...
2 days ago
Director Net Revenue Management
$125K - $150K *
Lead the charge in optimizing revenue performance by analyzing reimbursement trends, collaborating with teams to resolve discrepancies, and driving strategic initiatives to enhance financial outcomes...
2 days ago
Manager Claims and Litigation HPL PPL GL
$80K - $95K *
Join a team that's dedicated to excellence in risk management by supervising and mentoring a skilled group of Claims Specialists. Drive operational success through performance evaluations and expert g...
2 days ago
Senior Network Architect Security
$120K - $145K *
Shape the future of network security by leading global architecture, optimizing firewall ecosystems, and aligning strategies with cross-functional teams to enhance organizational security standards an...
2 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.