Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $100K *

Empower client success by managing portfolios, ensuring operational efficiency, and supporting Client Managers. Develop essential skills in data accuracy and communication while contributing to high c...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $180K *

Unlock potential by driving Brand P&L through strategic leadership and marketing execution across the Home and Garden division, achieving ambitious sales, GM, and EBITDA goals through integrated omnic...

Reposted yesterday

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$90K - $110K *

Transform patient care by delivering advanced palliative services in home settings. Collaborate with an interdisciplinary team to enhance quality of life for patients facing complex medical challenges...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$132K - $302K *

Drive the solution architecture vision for large-scale Salesforce Life Sciences programs, ensuring alignment across functional design and technical implementation while mentoring teams and engaging wi...

Reposted yesterday

  •   8 - 10 years exp.  •   Business Services

$87K - $293K *

Unlock your potential by leading SAP revenue transformation projects, collaborating with clients to enhance billing and accounting processes. Drive innovation in high-volume transaction environments a...

Yesterday

  •   5 - 7 years exp.  •   Business Services

$70K - $196K *

Champion enterprise-grade SAP data migration strategies, leveraging your expertise to design, implement, and optimize Master Data Governance processes while collaborating with clients and delivery tea...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$70K - $196K *

Unlock potential by leading SAP data migration initiatives, designing enterprise-grade strategies, and delivering integrated planning solutions. Collaborate across project lifecycles to modernize fina...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$116K - $174K *

Transform operations by leading teams to achieve strategic goals, ensuring compliance and quality standards while fostering a culture of belonging and continuous improvement. Drive financial performan...

Yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$94K - $266K *

Join a team that's driving strategic growth across the Americas. You'll analyze complex business challenges, develop actionable strategies, and collaborate with leadership to implement solutions that...

Reposted yesterday

  •   Less than 5 years exp.  •   Business Services

$134K - $201K *

Optimize the future of advanced therapies by driving complex CDMO deals, managing stakeholder relationships, and leveraging deep CGT expertise. Collaborate cross-functionally to promote growth and sha...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $145K *

Join a dynamic team to design, develop, and maintain full-stack applications, leveraging Python, AWS, and Terraform. Lead projects from ideation to deployment while mentoring junior engineers and ensu...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$88K - $147K *

Engage with a dynamic team to lead and develop property claims adjusters, enhancing their skills in coverage interpretation and customer communication while adapting to evolving claims processes and t...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$160K - $180K *

Join a team that's driving client success by managing strategic relationships and ensuring the financial health of key accounts. Leverage your expertise to bridge business goals with technical solutio...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$135K - $148K *

Drive the successful delivery of complex enterprise projects, ensuring timely execution and high-quality standards. Collaborate cross-functionally to meet client objectives and enhance project managem...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$115K - $140K *

Drive operational excellence and commercial readiness in a dynamic biotech environment. Collaborate cross-functionally to support launch activities, data management, and performance reporting, ensurin...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$225K - $275K *

Optimize quality assurance processes to ensure compliance with regulatory standards and drive improvements across all operations. Lead a talented team to establish and maintain an effective Quality Ma...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $185K *

Architect comprehensive clinical supply strategies for global trials. Collaborate across functional teams to secure timely, compliant drug supply while managing risks and inventory effectively, ensuri...

United StatesRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$64K - $128K *

Engage in driving store sales and managing a team to ensure efficient operations, guest satisfaction, and inventory accuracy. Lead initiatives in merchandising and fulfillment while fostering a cultur...

Reposted yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$150K - $180K *

Transform global supply chain operations by leading strategic sourcing, enhancing supplier performance, and establishing resilient logistics across multiple regions. Drive collaboration between teams...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Aerospace & Defense

$90K - $110K *

Lead customer engagement by driving acquisition, relationship management, and sales growth. Collaborate with internal teams to enhance customer satisfaction and product adoption in a dynamic, fast-pac...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Information Technology

$83K *

Lead the charge in optimizing plant shutdowns by managing timelines, coordinating maintenance tasks, and ensuring safety compliance. Collaborate with teams to enhance operational efficiency and reliab...

Yesterday

  •   Less than 5 years exp.  •   Food & Beverages

$80K - $100K *

Unlock your potential by driving sales in the water restoration sector. Engage with customers, assess property needs, and provide tailored solutions while enjoying flexible schedules and unlimited ear...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$108K - $130K *

Lead product security and compliance initiatives, ensuring clients meet regulatory standards across diverse sectors. Drive client engagement, deliver assessments, and enhance cybersecurity resilience...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$80K - $90K *

Join a team that's dedicated to providing compassionate hospice care, collaborating with an interdisciplinary team to enhance the quality of life for patients and families facing terminal diagnoses th...

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to designing impactful airport engineering projects. Collaborate on construction plans and technical specifications while enhancing your skills in a fast-paced environment...

Reposted yesterday

  •   Less than 5 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.