Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,967

Sort By: Relevance

$135K - $160K *

Transform healthcare technology by owning core products, driving architectural decisions, and ensuring high-quality code. Collaborate across teams to deliver impactful solutions that enhance patient c...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$63K - $111K *

Transform your career by joining a dynamic team as a Security Technician, where you'll travel to install, troubleshoot, and maintain advanced electronic systems, ensuring operational excellence across...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$88K - $115K *

Unlock potential by leading the renewals process, collaborating with cross-functional teams to enhance customer relationships and drive strategic growth opportunities for long-term success...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Drive procurement excellence by managing supplier relationships and optimizing processes. Take ownership of sourcing strategies, ensuring compliance and cost savings while mentoring team members in a...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$125K - $150K *

Empower healthcare practices by serving as a strategic advisor, enhancing financial performance and operational strategies. Lead client relationships and support growth initiatives in a dynamic, entre...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$130K - $150K *

Lead the charge in designing and implementing HR Service Delivery solutions, integrating Microsoft 365 with ServiceNow. Optimize employee experiences through automated workflows and seamless connectio...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$230K - $290K *

Drive the architecture and strategy for a high-volume telemetry platform, mentoring a team while collaborating across functions to enhance observability practices and ensure system reliability at scal...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$152K - $190K *

Join a team that's transforming industries through IoT solutions, driving impactful sales from prospecting to closing. Engage with executives, build lasting relationships, and thrive in a high-perform...

RemoteRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Lead the charge in enhancing engineering security for our SaaS platform. Collaborate with teams to identify risks, improve practices, and implement automation, ensuring secure development and robust v...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$144K - $209K *

Drive innovation by building scalable software solutions in a dynamic environment. Collaborate across teams to enhance user experiences and tackle complex challenges while leveraging cutting-edge tech...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$210K - $250K *

Empower a dynamic team of reimbursement professionals to enhance provider access and education. Drive strategic initiatives, foster collaboration, and ensure compliance while navigating complex payer...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the development and implementation of health policy initiatives that align with organizational goals. Collaborate with stakeholders to influence policy decisions and improve health outcomes at lo...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $120K *

Help us drive sales growth and enhance community partnerships by leading a dynamic sales team focused on expanding market share and improving patient registrations in the healthcare sector...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$104K - $194K *

Transform your career by spearheading agency relationships and driving profitable Inland Marine solutions while managing a territory remotely, influencing business growth through strategic underwritin...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$155K - $197K *

Innovate as a Tech Lead, driving architectural evolution and engineering execution for a global web platform. Collaborate with cross-functional teams to enhance digital experiences through advanced AI...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $190K *

Unlock your potential as a key player in software development, leading projects from design to deployment. Collaborate with cross-functional teams to enhance applications, optimize performance, and dr...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$138K - $187K *

Lead cross-functional quality initiatives to enhance product health and compliance. Collaborate with diverse teams on regulatory submissions, quality assessments, and process improvements for late-sta...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $155K *

Join a team that's redefining product marketing by crafting compelling narratives and lifecycle campaigns that drive customer engagement and platform adoption across diverse segments. Collaborate with...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$175K *

Champion enrollment growth by leading a high-performing team, optimizing processes, and enhancing the student experience. Collaborate cross-functionally to drive strategic initiatives and achieve meas...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Join a dynamic team to enhance application security across web apps, APIs, and cloud services. Collaborate with development squads to prioritize vulnerabilities and implement proactive remediation str...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$115K - $181K *

Manage and grow a diverse portfolio of health plan customers, driving satisfaction and retention. Build strategic relationships, navigate complex payor landscapes, and champion clinical outcomes to de...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$168K - $281K *

Lead the charge in Proactive Defense Operations, transforming threat data into automated defenses. Drive strategy, team performance, and operational excellence while collaborating across functions to...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Unlock potential by leading compliance audits, ensuring accurate coding and documentation in anesthesia. Collaborate with teams to mitigate risks, deliver training, and maintain regulatory standards w...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $177K *

Lead and develop a distributed team of Project Coordinators, enhancing operational health and governance across complex automation deployments while driving continuous improvement and collaboration wi...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Advance sales performance by leading a dynamic team, driving revenue growth, and optimizing strategies through collaboration with operations and marketing to achieve business objectives...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.