Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,967

Sort By: Relevance

$78K - $108K *

Empower our growth by managing and negotiating sales contracts, collaborating with cross-functional teams to ensure compliance and efficiency. Your expertise will drive impactful solutions in a dynami...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$125K - $160K *

Join a dynamic team as a Sr. Health Benefit Plan Consulting Attorney, leveraging your expertise in healthcare law to navigate complex regulatory issues, support consulting services, and drive complian...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $90K *

Manage and analyze Lost-Time Workers Compensation claims, ensuring timely resolution and adherence to service expectations. Collaborate with clients and stakeholders to deliver innovative solutions in...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$66K - $102K *

Optimize client solutions by leveraging SAP FICO expertise to analyze, design, and implement financial processes. Collaborate with teams to enhance system functionality and ensure seamless integration...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$134K - $249K *

Lead the charge in enhancing clinical systems operations, driving efficiency and effectiveness across pharmacy initiatives while managing a dedicated team and overseeing complex workflows and data int...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Take ownership of key client relationships, driving growth in the renewable energy analytics sector while collaborating across teams to support long-term strategic goals and ensure client success with...

RemoteRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$95K - $133K *

Join a team that's building and leading a high-performing Business Development group. Drive prospecting strategies, enhance team performance, and collaborate with Sales and Marketing to accelerate pip...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Business Services

$80K - $95K *

Lead a dynamic team of travel therapy recruiters while driving personal production. Champion recruitment strategies, enhance team performance, and ensure alignment with client demands to achieve booki...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Staffing

$80K - $150K *

Unlock potential by driving hardware security assessments, improving client security postures, and delivering actionable insights. Collaborate with teams and engage directly with clients while enhanci...

RemoteRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Optimize integration processes by bridging technical gaps between systems. Collaborate with campus IT to ensure seamless data flows, troubleshoot issues, and enhance integration reliability for succes...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$190K - $267K *

Champion innovation by leading cross-functional teams to design and deliver scalable, high-performance infrastructure solutions that enhance reliability and efficiency across diverse applications and...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Media

$130K - $160K *

Join a team that's building from the ground up, shaping the engineering foundation and culture while collaborating closely with leadership to define and deliver innovative products...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$500K+*

Join a team that's driving sales success through strategic leadership and collaboration. Oversee resource planning, manage budgets, and coach a team of Regional Sales Managers while achieving revenue...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$250K - $500K+*

Optimize and innovate software kernels for hardware integration, collaborating with ML Research and Hardware Engineering teams to enhance performance and efficiency in cutting-edge technology applicat...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$165K - $225K *

Elevate infrastructure capabilities by designing and implementing a unified platform that integrates bare-metal servers, storage, and networking for large-scale computation and AI workloads, ensuring...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Champion growth by owning the full sales cycle, educating clients, and driving custom part sourcing for hardware companies. Collaborate with a remote team to deliver exceptional service and build last...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$170K - $200K *

Transform customer experiences by providing technical expertise and solutions. Collaborate with sales and engineering teams to deliver impactful product demonstrations and address technical challenges...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $200K *

Join a team that's dedicated to advancing clinical research by leading operational aspects of trials, ensuring compliance with protocols and regulations, and fostering collaboration among stakeholders...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $220K *

Lead transformative technology initiatives as a strategic Chief Technology Officer, driving modernization and AI integration while ensuring business continuity and team development in a dynamic softwa...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$135K - $145K *

Lead the charge in optimizing payroll integration operations, managing teams, and driving strategic alignment across functions. Elevate customer experience through data-driven insights and innovative...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$189K - $231K *

Innovate and shape the future of AI platforms as a Senior Engineer, designing and building critical subsystems for enterprise Kubernetes environments. Collaborate with customers and mentor engineers t...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$187K - $281K *

Redefine market access strategies by leading payer engagement to enhance patient access to genomic testing. Collaborate cross-functionally to drive favorable coverage and reimbursement policies, ensur...

United StatesRemote

4 days ago

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$320K - $405K *

Transform the future of data center engineering by resolving on-site technical issues, collaborating with contractors, and ensuring project success through effective problem-solving and communication...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $160K *

Create impactful solutions as a Senior Product Engineer, owning projects from concept to delivery. Collaborate with a dynamic team, leveraging AI tools to enhance development while mentoring peers and...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Business Services

$466K - $500K+*

Elevate your career by building a cutting-edge ML data platform that enhances productivity for ML practitioners. Collaborate with experts to create innovative solutions for feature computation and sha...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.