Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,967

Sort By: Relevance

$70K - $110K *

Unlock your potential by analyzing data and conducting audits to enhance compliance for innovative B2B and B2C platforms. Collaborate with cross-functional teams, apply critical thinking, and gain ins...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $160K *

Drive high-volume technical recruitment efforts, focusing on specialized roles like Data Scientists and AI Engineers. Collaborate with hiring managers to build strong candidate pipelines and ensure an...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$184K - $356K *

Unlock potential by developing innovative AI solutions and enhancing infrastructure capabilities. Collaborate with strategic partners to deliver hands-on technical support, ensuring optimal performanc...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$85K - $111K *

Lead cross-functional teams to design and implement resilient infrastructure solutions. Collaborate with diverse stakeholders to ensure timely delivery of high-quality systems, leveraging automation a...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Business Services

$135K - $145K *

Deliver seamless integration and Tier 3 support for secure mobile infrastructure. Collaborate with enterprise stakeholders to ensure compliance, performance, and customer satisfaction while managing c...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $220K *

Champion innovation in macOS development, driving core sensor features for endpoint protection. Collaborate with a dynamic team to enhance security capabilities, ensuring high performance and reliabil...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$155K *

Transform complex challenges into impactful software solutions. Collaborate with engineers, designers, and justice leaders to drive product strategy and execution, enhancing the criminal justice syste...

RemoteRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $160K *

Take ownership of software engineering initiatives within established companies. Lead teams, modernize development processes, and enhance code quality while delivering impactful software solutions. Co...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$161K - $190K *

Join us to define and evolve the architecture of a cutting-edge digital platform, guiding engineering decisions and establishing shared services for scalable, secure, and reliable solutions that empow...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$85K - $115K *

Elevate healthcare education by developing evidence-based content for clinicians. Collaborate with experts to create innovative learning materials that address practice gaps and enhance professional s...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$135K - $160K *

Lead a dynamic team to transform AI strategies into impactful healthcare solutions. Oversee engineering execution, guide architecture, and ensure compliance while collaborating with cross-functional p...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$228K - $342K *

Empower your career by leading strategic project management initiatives across early drug development. Drive process optimization, cultivate high-performing teams, and collaborate with executives to a...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join a team dedicated to driving financial excellence in manufacturing. Oversee accounting, provide insights, and ensure compliance as the financial partner for plant operations, fostering a culture o...

Reposted 4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$100K - $110K *

Advance your career by conducting vital physical security evaluations across multiple data centers. Collaborate with teams to enhance security measures and protect critical infrastructure while engagi...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Join a team that's redefining product marketing by driving impactful go-to-market strategies, enabling sales teams, and translating complex product features into clear customer value across diverse ma...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$240K - $330K *

Join a team that’s pioneering growth in revenue intelligence by driving new business opportunities in financial services and healthcare. Leverage your extensive sales expertise to build relationships...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $90K *

Elevate culinary standards by managing kitchen operations in a dynamic healthcare setting, leading a dedicated team to deliver high-quality, nutritious meals while ensuring compliance with safety regu...

Reposted 4 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$172K - $216K *

Help us drive growth in the utilities sector by leading a high-performing sales team. You'll shape strategies, build relationships, and coach sellers to excel in complex, multi-year deals, ensuring al...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$120K - $180K *

Unlock potential by leading full-cycle sales in the corrections sector, driving innovative drone solutions. Collaborate with diverse teams to build trust and pipeline, while navigating complex agency...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$150K - $180K *

Champion innovative design solutions as a Principal Product Designer, leading UX strategy and AI experiences for a complex platform. Drive workflow transformation and mentor talent while shaping the f...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Unlock potential by driving pipeline visibility and forecasting accuracy. Collaborate with Sales, Marketing, and Finance to enhance workflows and insights, ensuring clean data and effective GTM strate...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$149K - $202K *

Transform the HCP launch landscape by leading innovative marketing initiatives for a groundbreaking treatment in Sjögren's disease. Collaborate cross-functionally to engage healthcare professionals an...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock potential by leading cross-functional initiatives to enhance caregiver enrollment technology. Drive strategy, optimize user experiences, and leverage data analytics to achieve growth in a dynam...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $125K *

Join a team that's transforming HR and payroll solutions by engaging clients, conducting tailored demos, and bridging business needs with technical expertise to enhance workforce management and compli...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$124K - $198K *

Transform your career by owning and accelerating Unstructured data protection sales. Leverage your technical expertise to drive growth, engage stakeholders, and win competitive deals in a dynamic, quo...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.