Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,967

Sort By: Relevance

$80K - $95K *

Optimize data management processes for large government acquisitions, ensuring effective communication between teams and shipyards. Lead document management, maintain schedules, and enhance data quali...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$191K - $238K *

Shape the future of oncology by leading medical strategy for prostate cancer projects. Collaborate with cross-functional teams to drive scientific communication and strategic initiatives, ensuring ali...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Drive enterprise growth by strategically engaging high-value accounts, orchestrating complex sales processes, and leveraging AI capabilities to enhance compliance workflows. Build executive relationsh...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $160K *

Drive the development of scalable software solutions, enhancing computer vision and LLM systems. Collaborate with cross-functional teams to deliver impactful features while ensuring reliability and ef...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$230K *

Lead the charge in rebuilding and managing a national Market Growth team, driving student enrollment through strategic partnerships and innovative local engagement. Foster a collaborative environment...

United StatesRemote

3 days ago

  •   15+ years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Lead the transformation of insights into actionable savings for clients. Collaborate with employers and vendors to optimize health benefits, drive execution, and enhance product offerings while shapin...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$145K - $222K *

Deliver impactful leadership by managing multi-discipline nuclear projects, ensuring alignment across teams, and guiding successful execution from design to closeout while maintaining client relations...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Technical Services

$131K - $190K *

Champion the design and optimization of scalable data pipelines and real-time ingestion frameworks, leading complex data initiatives while ensuring performance, reliability, and governance align with...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$102K - $172K *

Take ownership of complex outage management for gas and steam turbines, ensuring effective planning, execution, and closeout of events. Drive best practices and customer engagement while optimizing op...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$216K - $303K *

Discover an exciting opportunity to drive innovation in ad optimization and marketplace quality, creating impactful bidding and auction systems that enhance user experience and maximize advertiser suc...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Media

$88K - $105K *

Lead the charge in developing and executing multi-channel lifecycle strategies to enhance patient and provider engagement in mental healthcare. Collaborate across teams to optimize campaigns and drive...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$246K - $310K *

Champion a global events strategy that elevates brand awareness and drives executive engagement. Collaborate across teams to optimize event ROI and lead large-scale programs, ensuring compliance and e...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Manage and optimize critical data center operations, leading a team to ensure infrastructure reliability and efficiency. Foster a collaborative culture while overseeing maintenance, troubleshooting, a...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $200K *

Unlock potential by partnering with early-stage startups to build robust financial foundations. As a CFO-in-Residence, you'll drive critical finance functions, support fundraising, and shape strategic...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$104K - $174K *

Unlock your potential as a trusted legal advisor, providing strategic insights and guidance across multiple disciplines while mentoring others and enhancing operational efficiency through best practic...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$125K - $150K *

Champion developer engagement by leading community initiatives, social strategy, and programs that amplify Render's voice. Collaborate with cross-functional teams to enhance developer experience and d...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Empower data migration initiatives by leading project coordination, executing strategies, and ensuring quality reviews. Collaborate with teams to analyze and create data migration objects, driving eff...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$128K - $192K *

Unlock potential by driving new business growth through actionable health intelligence. Build relationships, identify client needs, and showcase solutions to enhance employee wellbeing and manage heal...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $100K *

Join a team that's dedicated to optimizing payroll operations and compliance. This role supports payroll processing, reporting, and employee services, ensuring accuracy and scalability as the organiza...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Unlock potential by leading the strategy and roadmap for a connected care platform, enhancing patient experiences through integrated technology solutions in healthcare settings. Drive product vision...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Deliver comprehensive patient care by assessing, diagnosing, and managing health issues. Collaborate with healthcare professionals and advocate for patients while enhancing nursing practices and suppo...

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$88K - $105K *

Optimize patient care quality and safety through strategic leadership, data-driven initiatives, and collaboration with healthcare teams to enhance service delivery and compliance with regulatory stand...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Join a dynamic team to elevate client relationships and deliver exceptional wealth management services, supporting key investment strategies and ensuring client satisfaction with detailed financial an...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Accelerate our events strategy by managing end-to-end logistics, driving engagement, and optimizing performance to enhance customer relationships and sales opportunities across diverse sectors...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Join a team that's redefining healthcare automation by developing intelligent solutions for Revenue Cycle Management. Leverage your Python expertise and computer vision skills to enhance efficiency an...

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.