Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,967

Sort By: Relevance

$230K - $322K *

Lead the development of machine learning models to enhance advertiser insights, optimizing campaign performance through advanced forecasting and scenario analysis. Collaborate across teams to drive im...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Media

$125K - $150K *

Transform business workflows by developing and maintaining applications that enhance productivity and information sharing across teams. Collaborate with IT and business units to deliver innovative sol...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Technical Services

$165K - $225K *

Champion the development of a GPU-accelerated compute platform, enhancing AI training and research capabilities. Collaborate with cross-functional teams to design orchestration systems that optimize r...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $195K *

Join a team that's redefining account marketing for major clients. Collaborate with cross-functional partners to drive growth, enhance customer engagement, and create tailored marketing strategies tha...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Innovate nursing practices by leading patient care initiatives, enhancing service delivery, and fostering collaboration across departments to improve satisfaction and operational efficiency in a dynam...

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$450K - $475K *

Drive revenue growth by leading a team of Regional Directors, fostering collaboration, and ensuring alignment with company goals. Your leadership will shape the region's success and culture while enha...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$99K - $155K *

Drive impactful marketing initiatives by executing campaigns, managing operations, and collaborating with teams to enhance brand visibility and support sales growth. Leverage data insights to optimize...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Transform the future of AI-driven infrastructure products by leading strategic growth initiatives, collaborating closely with Marketing and Engineering, and influencing key product decisions for optim...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Grow enterprise SAP relationships by managing key accounts and driving new business. Leverage your expertise to expand client portfolios, develop strategic plans, and ensure client satisfaction while...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$163K - $224K *

Drive strategic planning and execution of acquisitions/divestitures, ensuring seamless integration and value creation across teams. Collaborate cross-functionally to manage milestones, risks, and comm...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$144K - $240K *

Transform healthcare delivery by leading strategic initiatives and optimizing infusion services. Drive client success through expert guidance, operational excellence, and innovative solutions, ensurin...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Take ownership of the Colleague Accounts Receivable solutions, collaborating with higher education clients to design, implement, and optimize systems while ensuring effective billing, payment processi...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Transform AI infrastructure by designing and maintaining production-grade systems across multiple cloud providers. Engage in hands-on architecture decisions, ensuring reliability, security, and automa...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Unlock potential by leading pre-sales technical strategies that align solutions with client needs, driving revenue growth and retention through collaboration with sales teams and delivering tailored p...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$63K - $108K *

Lead enterprise accounts with 75+ locations, driving SaaS adoption and maximizing business value. Utilize industry expertise to resolve challenges, enhance client relationships, and support strategic...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$189K - $235K *

Lead the marketing investment strategy, optimizing budget allocation between brand and performance. Collaborate with finance and executive teams to ensure effective spending and measurable returns, dr...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$95K - $115K *

Transform control systems in the field as you analyze PLC code, troubleshoot equipment, and ensure regulatory compliance. Collaborate with internal teams and clients while traveling extensively across...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$128K - $192K *

The Workday Financials Integrations Senior Principal Consultant - Global AMS is a seasoned professional responsible for leading integration efforts and managing Workday financial services for clients...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $140K *

Transform campus public safety through innovative drone solutions, managing full-cycle sales in a competitive market. Build relationships, drive consensus, and leverage AI tools to enhance safety prog...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$78K - $85K *

Lead the charge in executing influencer marketing projects from inception to completion, ensuring exceptional client service and strategic solutions while managing timelines, budgets, and cross-functi...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Media

$132K - $193K *

Lead the charge in portfolio strategy and governance, aligning enterprise initiatives with corporate priorities. Drive investment decisions and enhance execution across Product Infrastructure, ensurin...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$80K - $200K *

Unlock new membership growth by engaging small business owners through face-to-face sales, building trust, and delivering tailored solutions. Drive results in a dynamic B2B environment focused on pros...

3 days ago

  •   Less than 5 years exp.  •   Business Services

$80K - $95K *

Champion the accounts payable process by leading a dynamic team, ensuring accuracy and efficiency from invoice receipt to payment. Collaborate across departments to enhance workflows and drive automat...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$91K - $190K *

Drive the charge in advancing Anaplan strategies, leading diverse teams to optimize solutions that align with business objectives. Collaborate with stakeholders to enhance the Anaplan ecosystem and en...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $110K *

Lead the charge in ensuring food safety through comprehensive audits, collaborating with teams to uphold certification standards, and providing expert recommendations for compliance and improvement in...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.