Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$96K - $210K *

Join a team that's dedicated to providing tailored financial strategies for senior executives. As a trusted advisor, you'll enhance client relationships and drive business growth through personalized...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$115K - $120K *

Innovate solutions for time capture and billing in a dynamic team. Leverage AI tools to enhance software development, ensuring accuracy and efficiency in invoicing processes while collaborating across...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Business Services

$80K - $96K *

Join a team that's driving automation and digital transformation in government and defense. Leverage your RPA expertise to design, develop, and deploy innovative solutions while collaborating with div...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$74K - $91K *

Contribute to national health data collection efforts by leveraging your nursing expertise and survey research skills. Engage in participant-centered data collection, quality control, and training whi...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$119K - $221K *

Advance your career by driving strategic sales initiatives within large enterprises. Collaborate with cross-functional teams to exceed sales quotas and develop innovative solutions that meet client ne...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$140K - $170K *

Join us to drive growth in the travel loyalty sector by building relationships with airlines, hotels, and gaming operators. You'll lead new business initiatives, shaping partnerships that enhance cust...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $200K *

Lead the charge in providing tailored financial planning and investment strategies for senior executives. Collaborate with a dedicated team to enhance client relationships and drive business growth wh...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$130K - $163K *

Champion the analytical validation of NGS assays, driving real-world evidence studies and collaborating with cross-functional teams to enhance oncology applications and support regulatory submissions...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $198K *

Contribute to leadership development and talent management initiatives while partnering with stakeholders to strengthen organizational capability and talent pipelines, ensuring alignment with workforc...

Reposted 2 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$175K - $215K *

Lead the charge in driving strategic growth and client satisfaction by managing senior-level relationships, leveraging cross-functional resources, and delivering measurable business value within a por...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Champion the clinician experience by designing and optimizing tools that enhance daily workflows, ensuring seamless integration of clinical data and improving patient care delivery in home settings...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Shape the future of networking by designing and implementing advanced SDN orchestration systems for high-performance, isolated networking in distributed computing environments, enabling seamless acces...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$83K - $222K *

Transform data engineering practices by designing robust data pipelines and models. Collaborate with cross-functional teams to enhance analytics capabilities and ensure data quality, governance, and p...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$183K - $301K *

Accelerate growth by leading strategic partnerships and go-to-market initiatives in the healthcare ecosystem. Drive revenue through collaboration, executive influence, and innovative business models w...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Healthcare

$83K - $133K *

Optimize engineering processes and lead design for utility substation protection systems. Ensure effective project execution, collaborate with multidisciplinary teams, and maintain adherence to indust...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$78K - $119K *

Lead the charge in enhancing palliative care operations, ensuring high-quality support for patients with advanced chronic illnesses. Collaborate with diverse teams to improve care coordination and pat...

Pascagoula, MSRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$54K - $159K *

Pioneer the implementation of customer benefit plans for self-funded clients, ensuring alignment with organizational goals. Lead project execution, manage risks, and coach teams to exceed client expec...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $159K *

Inspire excellence in clinical documentation by leading a team of specialists, ensuring quality assurance, and fostering professional development. Collaborate with stakeholders to enhance operational...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$280K - $360K *

Accelerate progress at building and expanding a territory across the Pacific Northwest and Mountain Range States, driving enterprise software sales and fostering relationships with key stakeholders in...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$175K - $200K *

Join a team that's dedicated to overseeing compliance and security initiatives, including FedRAMP and SOC audits. Collaborate across departments to enhance data protection and drive organizational suc...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$113K - $254K *

Drive innovation by developing scalable Python services and AI-driven solutions. Collaborate with data science teams to enhance pricing automation and improve operational efficiency in a fully remote...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Transportation

$132K - $170K *

Transform client relationships and drive growth by consulting with C-level executives to implement strategic solutions that enhance value and satisfaction across major accounts, ensuring retention and...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Business Services

$172K - $202K *

Lead the charge in delivering innovative insights and strategies for clients, leveraging in-depth market analysis and research expertise to address complex challenges and drive actionable results for...

United StatesRemote

Reposted 2 days ago

  •   11 - 15 years exp.  •   Business Services

$120K - $145K *

Accelerate commercial growth by defining strategies for product families, collaborating across teams to translate market insights into actionable plans that drive revenue, profitability, and customer...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Healthcare

$180K - $220K *

Lead the sales strategy for a healthcare Payer business unit, driving market penetration, revenue growth, and client satisfaction. Collaborate with leadership to shape go-to-market strategies and buil...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.