Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$123K - $218K *

Take ownership of complex project delivery across multiple teams, ensuring timely execution of high-stakes initiatives. Collaborate with engineers and researchers to optimize project management practi...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Drive business growth by developing and executing sales strategies, identifying prospects, and nurturing client relationships in the fleet management sector. Collaborate with teams to enhance customer...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Transportation

$80K - $130K *

Optimize marketing workflows by building AI agents and automated systems. Collaborate with teams to enhance CRM and lifecycle automation, focusing on performance marketing and organic growth through i...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Take ownership of a 24x7 Security Operations Center, leading a team of SOC analysts. Drive performance, manage client relationships, and ensure high-quality investigations while fostering team develop...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Empower your career by managing HR functions, enhancing employee relations, and ensuring compliance. Lead payroll, benefits, and engagement initiatives while supporting managers and driving HR program...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Technical Services

$95K - $115K *

Elevate financial analysis by leading evaluations of distressed debt portfolios, managing due diligence, and assessing creditworthiness. Collaborate across teams to optimize asset recovery and deliver...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Business Services

$105K - $125K *

Engage in a dynamic product role, driving AI-assisted development from concept to delivery. Collaborate with cross-functional teams to enhance workforce analytics, ensuring customer needs shape produc...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Champion advanced inventory control initiatives, leveraging analytical expertise to optimize inventory accuracy and governance. Collaborate cross-functionally to resolve complex issues and enhance ope...

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Drive innovation by enhancing CI/CD systems for ML models, automating testing and deployment processes. Collaborate with teams to streamline workflows, reduce manual tasks, and ensure reliable model r...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a dynamic team to design and optimize enterprise infrastructure, leading initiatives in network architecture, virtualization, and cloud services while ensuring reliability and security across sys...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Grow your career by driving strategic account management and revenue expansion for mid-market clients. Engage with key decision-makers, develop tailored solutions, and lead negotiations to foster long...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$89K - $136K *

Innovate clinical application support to enhance patient care efficiency. Manage software upgrades, coordinate with IT teams, and lead projects while ensuring compliance and effective communication ac...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$154K - $208K *

Elevate global wellbeing initiatives by leading a diverse team to create inclusive, sustainable strategies that enhance employee experiences and align with organizational goals, utilizing data-driven...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$120K - $145K *

Lead the development of critical firmware for safety-critical systems, collaborating across teams to optimize embedded platforms. Drive best practices and mentor engineers while ensuring reliability a...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Transportation

$139K - $179K *

Develop and execute impactful marketing campaigns that enhance brand awareness and drive pipeline growth in the AMERs region. Collaborate with cross-functional teams to optimize strategies and ensure...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Business Services

$210K - $250K *

Lead a dynamic team to drive growth and commercialization strategies, enhancing market presence and client acquisition. Collaborate cross-functionally to transform insights into actionable plans, ensu...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Analyze and enhance the digital customer journey by leading automation initiatives and cross-functional programs. Collaborate with teams to identify friction points and implement solutions that improv...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $137K *

Lead the charge in cloud migration by managing infrastructure engineering tasks, executing migrations to Azure and AWS, and ensuring operational readiness for applications and services in a dynamic, r...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$300K - $350K *

Drive sales growth in the cybersecurity sector by acquiring new accounts, building relationships, and ensuring customer satisfaction. Leverage your expertise to exceed quotas and manage Channel Partne...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$73K - $115K *

Launch your engineering career by tackling real manufacturing challenges. Engage in a three-year rotational program that fosters growth through mentorship, diverse experiences, and exposure to industr...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Business Services

$90K - $110K *

Lead the charge in resolving complex technical issues, enhancing support processes, and collaborating with engineering teams to improve product functionality and customer satisfaction in a dynamic B2B...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$83K - $95K *

Join a team that's shaping the future of nursing education by teaching innovative online Pediatrics courses. Engage students with cutting-edge methodologies and foster a vibrant online learning cultur...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$98K - $130K *

Drive financial excellence by leading cost accounting operations, ensuring accurate reporting and analysis. Collaborate across departments to support strategic business decisions and contribute to tim...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$195K - $264K *

Drive global regulatory strategies for obesity and cardiometabolic disorders, ensuring alignment across teams and leading interactions with health authorities. Leverage scientific expertise to navigat...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$217K - $294K *

Innovate the U.S. Cardiovascular & Metabolic Medical strategy, leading evidence generation and stakeholder engagement for chronic weight management. Collaborate cross-functionally to ensure launch rea...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.