Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $110,961
Senior Technical Program Manager
$123K - $218K *
Take ownership of complex project delivery across multiple teams, ensuring timely execution of high-stakes initiatives. Collaborate with engineers and researchers to optimize project management practi...
2 days ago
Business Development Manager - California
$100K - $120K *
Drive business growth by developing and executing sales strategies, identifying prospects, and nurturing client relationships in the fleet management sector. Collaborate with teams to enhance customer...
2 days ago
$80K - $130K *
Optimize marketing workflows by building AI agents and automated systems. Collaborate with teams to enhance CRM and lifecycle automation, focusing on performance marketing and organic growth through i...
2 days ago
Manager, Security Operations Center
$110K - $130K *
Take ownership of a 24x7 Security Operations Center, leading a team of SOC analysts. Drive performance, manage client relationships, and ensure high-quality investigations while fostering team develop...
2 days ago
$80K - $95K *
Empower your career by managing HR functions, enhancing employee relations, and ensuring compliance. Lead payroll, benefits, and engagement initiatives while supporting managers and driving HR program...
2 days ago
$95K - $115K *
Elevate financial analysis by leading evaluations of distressed debt portfolios, managing due diligence, and assessing creditworthiness. Collaborate across teams to optimize asset recovery and deliver...
2 days ago
$105K - $125K *
Engage in a dynamic product role, driving AI-assisted development from concept to delivery. Collaborate with cross-functional teams to enhance workforce analytics, ensuring customer needs shape produc...
2 days ago
$80K - $95K *
Champion advanced inventory control initiatives, leveraging analytical expertise to optimize inventory accuracy and governance. Collaborate cross-functionally to resolve complex issues and enhance ope...
2 days ago
Senior Software Engineer, Machine Learning Infrastructure & Automation
$135K - $160K *
Drive innovation by enhancing CI/CD systems for ML models, automating testing and deployment processes. Collaborate with teams to streamline workflows, reduce manual tasks, and ensure reliable model r...
Reposted 2 days ago
Infrastructure Architecture Manager
$110K - $130K *
Join a dynamic team to design and optimize enterprise infrastructure, leading initiatives in network architecture, virtualization, and cloud services while ensuring reliability and security across sys...
2 days ago
Commercial Account Executive - Mid Market (Remote)
$80K - $95K *
Grow your career by driving strategic account management and revenue expansion for mid-market clients. Engage with key decision-makers, develop tailored solutions, and lead negotiations to foster long...
2 days ago
Applications Analyst-Clinical-Sr
$89K - $136K *
Innovate clinical application support to enhance patient care efficiency. Manage software upgrades, coordinate with IT teams, and lead projects while ensuring compliance and effective communication ac...
2 days ago
$154K - $208K *
Elevate global wellbeing initiatives by leading a diverse team to create inclusive, sustainable strategies that enhance employee experiences and align with organizational goals, utilizing data-driven...
2 days ago
Senior Embedded Software Engineer
$120K - $145K *
Lead the development of critical firmware for safety-critical systems, collaborating across teams to optimize embedded platforms. Drive best practices and mentor engineers while ensuring reliability a...
2 days ago
$139K - $179K *
Develop and execute impactful marketing campaigns that enhance brand awareness and drive pipeline growth in the AMERs region. Collaborate with cross-functional teams to optimize strategies and ensure...
Reposted 2 days ago
Senior Vice President, Growth & Commercialization
$210K - $250K *
Lead a dynamic team to drive growth and commercialization strategies, enhancing market presence and client acquisition. Collaborate cross-functionally to transform insights into actionable plans, ensu...
2 days ago
$120K - $140K *
Analyze and enhance the digital customer journey by leading automation initiatives and cross-functional programs. Collaborate with teams to identify friction points and implement solutions that improv...
2 days ago
$90K - $137K *
Lead the charge in cloud migration by managing infrastructure engineering tasks, executing migrations to Azure and AWS, and ensuring operational readiness for applications and services in a dynamic, r...
2 days ago
Enterprise Account Executive, Georgia
$300K - $350K *
Drive sales growth in the cybersecurity sector by acquiring new accounts, building relationships, and ensuring customer satisfaction. Leverage your expertise to exceed quotas and manage Channel Partne...
2 days ago
Manufacturing Rotational Program Associate - Chemours Leadership LAB (Early Career)
$73K - $115K *
Launch your engineering career by tackling real manufacturing challenges. Engage in a three-year rotational program that fosters growth through mentorship, diverse experiences, and exposure to industr...
2 days ago
$90K - $110K *
Lead the charge in resolving complex technical issues, enhancing support processes, and collaborating with engineering teams to improve product functionality and customer satisfaction in a dynamic B2B...
2 days ago
Pediatric Online Didactic Faculty
$83K - $95K *
Join a team that's shaping the future of nursing education by teaching innovative online Pediatrics courses. Engage students with cutting-edge methodologies and foster a vibrant online learning cultur...
2 days ago
$98K - $130K *
Drive financial excellence by leading cost accounting operations, ensuring accurate reporting and analysis. Collaborate across departments to support strategic business decisions and contribute to tim...
2 days ago
Director, Global Regulatory Affairs - Cardiometabolic Disorders
$195K - $264K *
Drive global regulatory strategies for obesity and cardiometabolic disorders, ensuring alignment across teams and leading interactions with health authorities. Leverage scientific expertise to navigat...
2 days ago
Asset Lead Medical Director - Obesity and Related Conditions
$217K - $294K *
Innovate the U.S. Cardiovascular & Metabolic Medical strategy, leading evidence generation and stakeholder engagement for chronic weight management. Collaborate cross-functionally to ensure launch rea...
2 days ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.