Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$155K - $188K *

Elevate employee benefits and retirement programs by leading strategic initiatives, ensuring compliance, and enhancing program effectiveness for a diverse workforce. Collaborate with cross-functional...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$164K - $240K *

Shape global procurement strategies to optimize costs and ensure supply continuity while pursuing innovation in sourcing and sustainability objectives...

United StatesRemote

Reposted 2 days ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$72K - $97K *

Join a dynamic team to support global clinical study delivery, ensuring quality and compliance in clinical operations. Collaborate with cross-functional teams to manage study logistics, data tracking...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Drive global FP&A process excellence by leading budget management, optimizing forecasting, and enhancing reporting standards. Collaborate with finance teams and executive leadership to support strateg...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$130K - $162K *

Empower growth by leading strategic product marketing initiatives that define go-to-market strategies, enhance product positioning, and drive collaboration across teams to deliver impactful narratives...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Empower teams by designing and building scalable, secure systems that enhance performance and reliability. Collaborate across disciplines to innovate with AI while maintaining a security-first approac...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Media

$118K - $180K *

Unlock potential by leading structural engineering reviews for renewable energy projects. Collaborate with multi-discipline teams to optimize design, support financing, and deliver actionable insights...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Technical Services

$125K - $150K *

Lead the charge in cloud security engineering by managing a team of experts to design and implement robust security controls across AWS, Azure, and GCP, ensuring compliance and operational excellence...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$102K - $173K *

Join us to advance semiconductor technology by delivering innovative process solutions, collaborating with teams, and enhancing customer satisfaction in a dynamic, field-based role that drives impactf...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Manage and coordinate field construction activities across multiple trades, ensuring safe, timely, and quality project execution while collaborating with subcontractors and clients throughout all proj...

Reposted 2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Optimize clinical support for Heart Alert Service by reviewing ECG episodes, ensuring accurate documentation, and collaborating across functions to enhance patient care and workflow efficiency...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Shape the future of higher education by leading complex SaaS modernization projects, aligning institutional goals with delivery execution, and fostering strong customer relationships to ensure success...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$99K - $198K *

Drive impactful sales training programs that enhance seller readiness and performance. Oversee curriculum development, training delivery, and stakeholder engagement to ensure alignment with business g...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $180K *

Elevate customer success by managing strategic federal programs, ensuring seamless implementation and adoption of innovative solutions. Collaborate with stakeholders to drive project execution and enh...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$67K - $199K *

Lead NCQA Health Outcomes and Community-Focused Care Accreditation initiatives, driving quality improvement and compliance across health plans. Collaborate with teams to enhance equitable health outco...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join our team to engineer high-quality automated test solutions, ensuring the reliability and performance of enterprise applications. Collaborate cross-functionally to deliver robust frameworks and le...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Information Technology

$142K - $250K *

Accelerate innovation in autonomous agriculture by leading product strategy, collaborating with engineering and commercial teams, and transforming customer insights into impactful solutions that drive...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$68K - $113K *

Pioneer innovative data-driven solutions to optimize client decision-making, leveraging cutting-edge analytics, visualization, and automation strategies. Collaborate with stakeholders to enhance opera...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Business Services

$315K - $350K *

Lead the charge in transforming enterprise actuarial capabilities, providing strategic oversight across modeling, valuation, and governance. Collaborate with executives to enhance decision-making and...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Finance & Insurance

$135K - $150K *

Lead the charge in optimizing HR technology and processes, ensuring seamless integration and governance across systems. Collaborate with key stakeholders to enhance the employee lifecycle and drive st...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$90K - $110K *

Drive customer success by managing strategic relationships, ensuring retention and growth for key accounts in the Bankruptcy Risk sector. Collaborate with cross-functional teams to deliver tailored so...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $96K *

Drive impactful SaaS sales by owning the full sales cycle, from prospecting to closing. Cultivate value-driven partnerships with mid-market promotional product distributors while collaborating with a...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $200K *

Join a team that's redefining partnerships in the automotive SaaS space. Lead strategic initiatives to enhance our developer ecosystem, drive commercial negotiations, and foster innovation across key...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Consumer Technology

$110K - $130K *

Elevate cloud contact center solutions by designing, implementing, and maintaining Amazon Connect systems. Collaborate on IVR flows, API integrations, and infrastructure automation to enhance customer...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Optimize reliability at a manufacturing facility by leading projects, resolving mechanical issues, and enhancing equipment performance. Collaborate with teams to ensure uptime and drive efficiency imp...

2 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.