Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $110,961
2026-11 Senior/Staff Software Engineer
$135K - $160K *
Drive the development of scalable backend systems and infrastructure for AI platforms. Collaborate with cross-functional teams to enhance automation, reliability, and performance while mentoring peers...
2 days ago
Program Manager, National Security - DHS
$145K - $175K *
Transform customer success by managing DHS accounts through the entire lifecycle, ensuring seamless delivery, adoption, and growth of Skydio systems while collaborating with cross-functional teams to...
2 days ago
Manager, Sales Recruiting (AMER)
$104K - $176K *
Lead and develop a high-performing Sales recruiting team across the Americas. Partner with Sales leaders to design scalable hiring strategies, enhance candidate experience, and drive revenue growth th...
2 days ago
Senior DevSecOps / Platform Engineer
$112K - $179K *
Champion the Agentic AI platform by owning its end-to-end operations, ensuring secure, reliable, and scalable delivery through advanced CI/CD practices, AWS infrastructure, and Kubernetes management...
Reposted 2 days ago
$207K - $366K *
Lead strategic account management initiatives, driving growth and client satisfaction through innovative solutions and cross-functional collaboration. Shape the future of client relationships by ensur...
2 days ago
$156K - $214K *
Inspire growth by leading an Enterprise CPG sales team, driving strategic partnerships with top-tier brands, and influencing C-suite executives to leverage innovative insights for impactful decisions...
2 days ago
$77K - $121K *
Unlock your potential as you lead organic social strategy, engage millions, and shape brand voice across platforms. Collaborate with creative teams to drive impactful content and community engagement...
2 days ago
T&D Construction Manager - Grid
$118K - $180K *
Join a dynamic team as a senior electrical engineer, providing technical leadership in substation design and commissioning. Leverage your expertise to ensure project success through collaboration, ove...
2 days ago
$105K - $165K *
Join a team that's dedicated to enhancing AI-powered consumer features by ensuring quality, safety, and performance through innovative engineering and evaluation practices. Collaborate across departme...
2 days ago
Account Executive, Product Sales (Terminal)
$125K - $150K *
Accelerate growth by leveraging your sales expertise to drive strategic deals for Unified Commerce solutions. Collaborate cross-functionally to enhance product knowledge and execute go-to-market strat...
2 days ago
$80K - $95K *
Drive growth by owning the cross-sell pipeline, leveraging data-driven strategies to engage high-volume clients and optimize operations for maximum customer lifetime value. Collaborate with teams to d...
2 days ago
$120K - $190K *
Unlock potential by leading the design and integration of advanced satellite communications systems. Drive system architecture, manage requirements, and collaborate across multi-disciplinary teams to...
2 days ago
$119K - $186K *
Champion the evolution of global AI governance and responsible data practices, ensuring compliance with regulations while driving operational efficiencies across cross-functional teams in a dynamic en...
2 days ago
$61K - $122K *
Optimize product delivery by bridging business needs and technical teams, leading requirement gathering, defining user stories, and ensuring alignment with stakeholders to enhance Epic EHR capabilitie...
2 days ago
$100K - $120K *
Inspire and lead a sales team while building client relationships and implementing effective strategies. Enjoy flexible scheduling and the opportunity to mentor others, all while providing tailored in...
Reposted 2 days ago
Senior Technical Program Manager
$115K - $172K *
Shape the future of healthcare by leading complex data ingestion initiatives. Collaborate with cross-functional teams to drive program delivery, manage risks, and ensure operational excellence while t...
2 days ago
$135K - $160K *
Pioneer a transformative deal desk to empower Sales with streamlined processes, enabling faster, defensible deal-making while collaborating closely with cross-functional teams to enhance pricing strat...
2 days ago
$110K - $130K *
Drive operational excellence as you manage tech stacks and workflows, delivering data-driven insights and aligning cross-functional teams for revenue growth and partner success...
Reposted 2 days ago
Enterprise Account Executive - Sports and Entertainment
$240K - $270K *
Elevate your career by leading the Sports and Entertainment vertical across North America. Drive customer acquisition and revenue growth through consultative selling and technical expertise, shaping t...
2 days ago
$95K - $115K *
Transform the ScriptMed Cloud Platform by designing and deploying scalable solutions. Collaborate with teams to automate workflows and enhance customer onboarding while ensuring compliance with data s...
2 days ago
Media Activation (Partner Media) Director, Partner Media
$110K - $130K *
Join a team that's driving innovative media strategies and partnerships. Oversee planning and execution of media investments across diverse channels, ensuring alignment with client objectives while fo...
2 days ago
Senior Manager, Security Engineering & Operations
$160K - $200K *
Lead and shape a high-performing Security Engineering and Operations team, driving proactive threat management and strategic engineering initiatives across North America while enhancing operational ef...
2 days ago
$78K - $148K *
Transform quality assurance processes by leading initiatives in engineering support, ensuring compliance with standards, and driving continuous improvement in product quality within a collaborative en...
2 days ago
Engineering Manager, Firewall Defense
$225K - $265K *
Lead the charge in developing a high-performing engineering team focused on firewall validation and security. Drive collaboration across technical and product teams while fostering an inclusive enviro...
2 days ago
Associate Customer Success Manager - Cisco
$75K - $125K *
Elevate your career by onboarding customers and driving their success through strategic reviews and relationship building. Collaborate with teams to align offerings and ensure a positive experience wh...
2 days ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.