Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$110K - $130K *

Empower our IT environment by enhancing security and reliability through hands-on systems engineering, cybersecurity, and incident response. Collaborate across teams to design, implement, and manage s...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Legal & Accounting

$238K - $341K *

Pioneer secure identity solutions by architecting a robust Identity & Trust platform. Lead multi-year strategies, drive high-impact initiatives, and mentor engineers to enhance customer onboarding and...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Champion enterprise growth by driving strategic account expansion and retention. Collaborate with cross-functional teams to influence executive stakeholders and execute complex sales strategies, ensur...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Drive new logo acquisition and revenue growth by managing the full sales cycle for assigned prospects, leveraging industry expertise and consultative selling to deliver tailored solutions and achieve...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Join a team that's transforming sales enablement by bridging insights and execution. Leverage market data and expertise to empower client engagement teams, enhance discovery processes, and drive effec...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$181K - $208K *

Drive enterprise transformation and AI adoption by leading cross-functional teams, aligning strategic priorities with measurable outcomes, and fostering collaboration across business and technology se...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $159K *

Unlock potential by joining a dynamic web engineering team to design, develop, and maintain scalable applications. Collaborate with cross-functional teams, mentor engineers, and enhance CI/CD practice...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$100K - $125K *

Execute complex enterprise implementations, translating customer needs into actionable strategies. Leverage your expertise to connect teams and drive successful onboarding while enhancing customer sat...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$145K - $218K *

Transform your career by driving clinical trial success through strategic site engagement and collaboration with key opinion leaders in Neuroscience and Oncology, enhancing patient enrollment and rete...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$75K - $90K *

Engage with strategic accounts to drive revenue growth through consultative sales and account management. Develop and maintain account plans, coordinate resources, and ensure customer satisfaction whi...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$118K - $178K *

Shape strategic initiatives by leading key deliverables and financial analyses. Collaborate with partners to enhance business processes and drive impactful recommendations, ensuring alignment and time...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Lead the charge in driving scalable revenue growth through integrated demand generation and digital marketing strategies. Collaborate with cross-functional teams to optimize marketing operations and e...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$174K - $250K *

Drive your career forward by partnering with executives to shape AI strategies, lead complex architecture discussions, and deliver tailored solutions that enhance enterprise AI ecosystems and revenue...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $170K *

Take ownership of strategic finance leadership, optimizing cash flow and credit risk while developing innovative financing solutions to drive profitable growth and enhance operational efficiency acros...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$170K - $220K *

Lead the charge in technology strategy and execution, overseeing software engineering, business systems, and IT. Drive innovation and efficiency while ensuring robust architecture and team development...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Food & Beverages

$135K - $160K *

Drive the development of scalable backend systems and infrastructure for AI platforms. Collaborate with cross-functional teams to enhance automation, reliability, and performance while mentoring peers...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$145K - $175K *

Transform customer success by managing DHS accounts through the entire lifecycle, ensuring seamless delivery, adoption, and growth of Skydio systems while collaborating with cross-functional teams to...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Consumer Technology

$104K - $176K *

Lead and develop a high-performing Sales recruiting team across the Americas. Partner with Sales leaders to design scalable hiring strategies, enhance candidate experience, and drive revenue growth th...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$112K - $179K *

Champion the Agentic AI platform by owning its end-to-end operations, ensuring secure, reliable, and scalable delivery through advanced CI/CD practices, AWS infrastructure, and Kubernetes management...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Aerospace & Defense

$207K - $366K *

Lead strategic account management initiatives, driving growth and client satisfaction through innovative solutions and cross-functional collaboration. Shape the future of client relationships by ensur...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Information Technology

$156K - $214K *

Inspire growth by leading an Enterprise CPG sales team, driving strategic partnerships with top-tier brands, and influencing C-suite executives to leverage innovative insights for impactful decisions...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Media

$77K - $121K *

Unlock your potential as you lead organic social strategy, engage millions, and shape brand voice across platforms. Collaborate with creative teams to drive impactful content and community engagement...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$118K - $180K *

Join a dynamic team as a senior electrical engineer, providing technical leadership in substation design and commissioning. Leverage your expertise to ensure project success through collaboration, ove...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Technical Services

$105K - $165K *

Join a team that's dedicated to enhancing AI-powered consumer features by ensuring quality, safety, and performance through innovative engineering and evaluation practices. Collaborate across departme...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Accelerate growth by leveraging your sales expertise to drive strategic deals for Unified Commerce solutions. Collaborate cross-functionally to enhance product knowledge and execute go-to-market strat...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.