Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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1,000+

Jobs in Mississippi

Average Salary in USD

Average Salary: $110,961

Sort By: Relevance

$108K - $155K *

Empower patient care by joining a dedicated team that provides telephonic support, addresses diverse medical and psychological needs, and enhances patient experiences while ensuring documentation accu...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$69K - $104K *

Unlock your potential by collaborating with leaders to enhance payor performance, streamline revenue cycle operations, and drive innovation in healthcare. Your expertise will ensure impactful engageme...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$100K - $231K *

Transform healthcare outcomes by leading a team of Clinical Program Consultants to analyze data, optimize clinical programs, and drive strategic initiatives that enhance customer health and reduce cos...

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Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Drive technical solutions as a client-facing architect, leveraging deep expertise in JavaScript, TypeScript, and Python to guide enterprise-level projects across multiple cloud environments and enhanc...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Unlock your potential by leading project procurement efforts, optimizing processes, and managing supplier relationships to enhance operational efficiency and profitability across diverse project categ...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Energy & Utilities

$120K - $160K *

Join a team that's redefining integrated marketing strategies, leading cross-channel campaigns that drive product narratives and customer engagement. Shape the future of marketing through collaboratio...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$124K - $224K *

Unlock potential by leading revenue operations, bridging sales, finance, and analytics. Drive forecasting, pipeline management, and team development to enhance business performance and ensure data int...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Energy & Utilities

$151K - $248K *

Unlock your potential by driving product innovation and cross-functional alignment in a dynamic environment. Lead initiatives that shape lending solutions, enhance decision-making, and deliver impactf...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$84K - $126K *

Unlock your potential by leading operations in a dynamic environment. Drive performance, enhance quality, and foster team development while ensuring compliance with safety standards and operational go...

Yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$119K - $180K *

Optimize SAP environments by administering, monitoring, and supporting SAP S/4HANA and related technologies. Collaborate with cross-functional teams to ensure a secure, high-performing system that mee...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Champion your career by leading security engagements, assessing architectures, and enhancing compliance. Collaborate with top professionals to identify risks and implement best practices, ensuring rob...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$139K - $235K *

Transform compensation strategies by leading program design and execution. Collaborate with cross-functional teams to ensure compliance, enhance processes, and deliver accurate outcomes that attract a...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$300K - $350K *

Join a team that's driving sales growth in the cybersecurity sector. This role focuses on acquiring new accounts, building customer relationships, and ensuring satisfaction while exceeding sales quota...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Join a team that's dedicated to enhancing information security through proactive assessments and innovative solutions. Contribute to compliance and risk management while implementing best practices in...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$138K - $165K *

Lead the charge in designing and deploying cutting-edge LLM applications that solve real user challenges. Drive the full AI development lifecycle, ensuring quality and scalability while transforming i...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Information Technology

$150K - $200K *

Transform revenue cycle operations by leading strategic initiatives, engaging stakeholders, and optimizing financial health through effective project management and collaboration across the organizati...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$43K - $150K *

Join a team that's dedicated to building strong client relationships while providing tailored financial advice. Leverage your investment expertise to help customers achieve their financial goals throu...

Reposted yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$125K - $150K *

Join a dynamic team as you oversee billing and revenue management, ensuring accuracy and efficiency while leading a talented group. Drive process improvements and support mergers in a rapidly growing...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Unlock potential by leading strategic digital transformation sales across industries. Drive complex pursuits integrating Cybersecurity, AI solutions, and Manufacturing Operations Management to enhance...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Join us to lead transformational sales in digital operations, driving complex solutions across cybersecurity and manufacturing. Collaborate with stakeholders to unlock value and accelerate customer ou...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$145K - $215K *

Elevate your career by managing key accounts in the rare disease sector. Drive sales, build relationships with healthcare professionals, and ensure compliance while achieving ambitious territory goals...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$211K - $285K *

Lead the charge in late-phase oncology clinical development, collaborating across teams to design and deliver impactful results. Provide expertise in clinical trial science and data analysis, ensuring...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$104K - $141K *

Lead the charge in transforming Human Genetics strategy into actionable plans, ensuring measurable progress across R&D. Collaborate with cross-functional teams to align priorities and drive successful...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$144K - $194K *

Accelerate progress at the forefront of oncology marketing by leading global initiatives, synthesizing insights, and driving execution across teams to enhance product strategies and launch readiness...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$145K - $215K *

Elevate your career by driving sales and education for innovative healthcare solutions. In this role, you'll manage accounts, build relationships with healthcare professionals, and enhance patient car...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.