Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
Average Salary: $111,063
Projects Procurement Manager USA
$110K - $130K *
Unlock your potential by leading project procurement efforts, optimizing processes, and managing supplier relationships to enhance operational efficiency and profitability across diverse project categ...
Yesterday
$120K - $160K *
Join a team that's redefining integrated marketing strategies, leading cross-channel campaigns that drive product narratives and customer engagement. Shape the future of marketing through collaboratio...
Yesterday
$124K - $224K *
Unlock potential by leading revenue operations, bridging sales, finance, and analytics. Drive forecasting, pipeline management, and team development to enhance business performance and ensure data int...
Yesterday
Let's begin! Director Product Manager- Banking (15734)
$151K - $248K *
Unlock your potential by driving product innovation and cross-functional alignment in a dynamic environment. Lead initiatives that shape lending solutions, enhance decision-making, and deliver impactf...
Yesterday
(USA) Operations Manager - Floor (fashion, Import, Jewelry, Regional, Returns, Sam's, Wm.com, Hmsc)
$84K - $126K *
Unlock your potential by leading operations in a dynamic environment. Drive performance, enhance quality, and foster team development while ensuring compliance with safety standards and operational go...
Yesterday
Senior Data Scientist, Marketing Measurement, Consumer Solutions
$115K - $130K *
Drive marketing measurement innovation by developing scalable frameworks and advanced analytics. Collaborate across teams to enhance performance tracking, optimize investment strategies, and deliver a...
Yesterday
$119K - $180K *
Optimize SAP environments by administering, monitoring, and supporting SAP S/4HANA and related technologies. Collaborate with cross-functional teams to ensure a secure, high-performing system that mee...
Yesterday
Consultant, Cyber Architecture
$110K - $130K *
Champion your career by leading security engagements, assessing architectures, and enhancing compliance. Collaborate with top professionals to identify risks and implement best practices, ensuring rob...
Yesterday
$139K - $235K *
Transform compensation strategies by leading program design and execution. Collaborate with cross-functional teams to ensure compliance, enhance processes, and deliver accurate outcomes that attract a...
Yesterday
Enterprise Account Executive, Ohio
$300K - $350K *
Join a team that's driving sales growth in the cybersecurity sector. This role focuses on acquiring new accounts, building customer relationships, and ensuring satisfaction while exceeding sales quota...
Yesterday
$90K - $110K *
Join a team that's dedicated to enhancing information security through proactive assessments and innovative solutions. Contribute to compliance and risk management while implementing best practices in...
Yesterday
Senior AI Engineer with RAG and Agentic architectures
$138K - $165K *
Lead the charge in designing and deploying cutting-edge LLM applications that solve real user challenges. Drive the full AI development lifecycle, ensuring quality and scalability while transforming i...
Reposted yesterday
Revenue Cycle Program Manager (Remote)
$150K - $200K *
Transform revenue cycle operations by leading strategic initiatives, engaging stakeholders, and optimizing financial health through effective project management and collaboration across the organizati...
Yesterday
Financial Advisor - South Mississippi
$43K - $150K *
Join a team that's dedicated to building strong client relationships while providing tailored financial advice. Leverage your investment expertise to help customers achieve their financial goals throu...
Reposted yesterday
$125K - $150K *
Join a dynamic team as you oversee billing and revenue management, ensuring accuracy and efficiency while leading a talented group. Drive process improvements and support mergers in a rapidly growing...
Yesterday
Sales Executive - Secure Digital Operations, Automotive & Tire
$110K - $130K *
Unlock potential by leading strategic digital transformation sales across industries. Drive complex pursuits integrating Cybersecurity, AI solutions, and Manufacturing Operations Management to enhance...
Yesterday
Sales Executive, Secure Digital Operations - OEM
$110K - $130K *
Join us to lead transformational sales in digital operations, driving complex solutions across cybersecurity and manufacturing. Collaborate with stakeholders to unlock value and accelerate customer ou...
Yesterday
Account Manager/Specialty Account Manager -KRYSTEXXA (Rare Disease) - Shreveport, LA
$145K - $215K *
Elevate your career by managing key accounts in the rare disease sector. Drive sales, build relationships with healthcare professionals, and ensure compliance while achieving ambitious territory goals...
Yesterday
Clinical Sciences Director, Oncology
$211K - $285K *
Lead the charge in late-phase oncology clinical development, collaborating across teams to design and deliver impactful results. Provide expertise in clinical trial science and data analysis, ensuring...
Yesterday
Business Performance Manager, Human Genetics
$104K - $141K *
Lead the charge in transforming Human Genetics strategy into actionable plans, ensuring measurable progress across R&D. Collaborate with cross-functional teams to align priorities and drive successful...
Yesterday
Global Marketing Senior Manager - Oncology (IMDELLTRA)
$144K - $194K *
Accelerate progress at the forefront of oncology marketing by leading global initiatives, synthesizing insights, and driving execution across teams to enhance product strategies and launch readiness...
Yesterday
Account Manager / Specialty Account Manager - IgG4 - (Rare Disease) - Jackson, MS
$145K - $215K *
Elevate your career by driving sales and education for innovative healthcare solutions. In this role, you'll manage accounts, build relationships with healthcare professionals, and enhance patient car...
Yesterday
Project Management, Senior Associate
$89K - $120K *
Drive collaboration across teams to coordinate scientific data, streamline processes, and enhance operational efficiency. This role requires strong judgment and the ability to manage cross-functional...
Yesterday
GEO Strategy & Operations Senior Manager, RDBU & Global
$143K - $194K *
Advance your career by driving GEO strategy and operations, coordinating cross-functional efforts, and optimizing digital marketing initiatives for a global brand portfolio in a dynamic and collaborat...
Reposted yesterday
Medical Value and Health Information Technology (MVHIT) Manager - Health IT Liaison - South Central
$110K - $130K *
Empower healthcare transformation by educating Integrated Delivery Networks on EHR systems. Collaborate with cross-functional teams to enhance patient management and care delivery through innovative h...
Yesterday
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.